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Submissions from 2023

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Moving beyond mortality: Development and Application of a Desirability of Outcome Ranking (DOOR) Endpoint for Hospital-Acquired Bacterial Pneumonia and Ventilator-Associated Bacterial Pneumonia, Jessica Howard-Anderson, Toshimitsu Hamasaki, Weixiao Dai, Deborah Collyar, Daniel Rubin, Sumathi Nambiar, Tori Kinamon, Heidi Leister-Tebbe, Carol Hill, Holly Geres, Thomas L. Holland, Sarah B. Doernberg, Henry F. Chambers, Vance G. Fowler, Scott R. Evans, and Helen W. Boucher

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An epidemiological introduction to human metabolomic investigations, Amit D. Joshi, Ali Rahnavard, Priyadarshini Kachroo, Kevin M. Mendez, Wayne Lawrence, Sachelly Julián-Serrano, Xinwei Hua, Harriett Fuller, Nasa Sinnott-Armstrong, Fred K. Tabung, Katherine H. Shutta, Laura M. Raffield, and Burcu F. Darst

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Chronic Kidney Disease Associates with Cognitive Decline in Middle-aged and Older Adults with Long-standing Type 1 Diabetes, Minesh Khatri, Christopher M. Ryan, Xiaoyu Gao, Ian H. de Boer, Barbara H. Braffett, Mark Molitch, Amy B. Karger, Gayle M. Lorenzi, Pearl Lee, Victoria R. Trapani, John M. Lachin, and Alan M. Jacobson

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Exploration of a Potential Desirability of Outcome Ranking Endpoint for Complicated Intra-Abdominal Infections Using 9 Registrational Trials for Antibacterial Drugs, Tori Kinamon, Ramya Gopinath, Ursula Waack, Mark Needles, Daniel Rubin, Deborah Collyar, Sarah B. Doernberg, Scott Evans, Toshimitsu Hamasaki, Thomas L. Holland, Jessica Howard-Anderson, Henry Chambers, Vance G. Fowler, Sumati Nambiar, Peter Kim, and Helen W. Boucher

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Reliability of Admission Procalcitonin Testing for Capturing Bacteremia Across the Sepsis Spectrum: Real-World Utilization and Performance Characteristics, 65 U.S. Hospitals, 2008-2017, Alexander Lawandi, Marissa Oshiro, Sarah Warner, Guoqing Diao, Jeffrey R. Strich, Ahmed Babiker, Chanu Rhee, Michael Klompas, Robert L. Danner, and Sameer S. Kadri

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Evaluating the balance of benefits and harms in chronic pain clinical trials: prioritizing individual participants over individual outcomes, Mahd Nishtar, Remington Mark, Dale J. Langford, Michael P. McDermott, John D. Markman, Scott R. Evans, Fallon O. France, Meghan Park, Sonia Sharma, Dennis C. Turk, Robert H. Dworkin, and Jennifer S. Gewandter

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Metagenomic profiling pipelines improve taxonomic classification for 16S amplicon sequencing data, Aubrey R. Odom, Tyler Faits, Eduardo Castro-Nallar, Keith A. Crandall, and W Evan Johnson

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Interlaboratory comparison of Pseudomonas aeruginosa phage susceptibility testing, Krupa Parmar, Lauren Komarow, Damon W. Ellison, Andrey A. Filippov, Mikeljon P. Nikolich, Joseph R. Fackler, Martin Lee, Anjna Nair, Priyesh Agrawal, Pranita D. Tamma, Maria Souli, Scott R. Evans, Kerryl E. Greenwood-Quaintance, Scott A. Cunningham, and Robin Patel

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Interlaboratory comparison of Pseudomonas aeruginosa phage susceptibility testing, Krupa Parmar, Lauren Komarow, Damon W. Ellison, Andrey A. Filippov, Mikeljon P. Nikolich, Joseph R. Fackler, Martin Lee, Anjna Nair, Priyesh Agrawal, Pranita D. Tamma, Maria Souli, Scott R. Evans, Kerryl E. Greenwood-Quaintance, Scott A. Cunningham, and Robin Patel

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Nasal Bacteriomes of Patients with Asthma and Allergic Rhinitis Show Unique Composition, Structure, Function and Interactions, Marcos Pérez-Losada, Eduardo Castro-Nallar, José Laerte Boechat, Luis Delgado, Tiago Azenha Rama, Valentín Berrios-Farías, and Manuela Oliveira

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Estimated COVID-19 vaccine effectiveness against seroconversion from SARS-CoV-2 Infection, March-October, 2021, Ian D. Plumb, Lida M. Fette, Ashley H. Tjaden, Leora Feldstein, Sharon Saydah, Amina Ahmed, Ruth Link-Gelles, Thomas F. Wierzba, Andrea A. Berry, DeAnna Friedman-Klabanoff, Moira P. Larsen, Michael S. Runyon, Lori M. Ward, Roberto P. Santos, Johnathan Ward, William S. Weintraub, Sharon Edelstein, and Diane Uschner

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Risk Factors for Perinatal Transmission of Hepatitis C Virus, Mona Prasad, George R. Saade, Rebecca G. Clifton, Grecio J. Sandoval, Brenna L. Hughes, Uma M. Reddy, Anna Bartholomew, Ashley Salazar, Edward K. Chien, Alan T. Tita, John M. Thorp, Torri D. Metz, Ronald J. Wapner, Vishakha Sabharwal, Hyagriv N. Simhan, Geeta K. Swamy, Kent D. Heyborne, Baha M. Sibai, William A. Grobman, Yasser Y. El-Sayed, Brian M. Casey, Samuel Parry, Mobeen Rathore, Rodrigo Diaz-Velasco, Ana M. Puga, Andrew Wiznia, Andrea Kovacs, David J. Garry, and George A. Macones

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Global epidemiology and clinical outcomes of carbapenem-resistant Pseudomonas aeruginosa and associated carbapenemases (POP): a prospective cohort study, Jinnethe Reyes, Lauren Komarow, Liang Chen, Lizhao Ge, Blake M. Hanson, Eric Cober, Erica Herc, Thamer Alenazi, Keith S. Kaye, Julia Garcia-Diaz, Lanjuan Li, Souha S. Kanj, Zhengyin Liu, Jose M. Oñate, Robert A. Salata, Kalisvar Marimuthu, Hainv Gao, Zhiyong Zong, Sandra L. Valderrama-Beltrán, Yunsong Yu, Paul Tambyah, Gregory Weston, Soraya Salcedo, Lillian M. Abbo, Qing Xie, Karen Ordoñez, Minggui Wang, Martin E. Stryjewski, Jose M. Munita, David L. Paterson, Scott Evans, and Carol Hill

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Daily fosfomycin versus levofloxacin for complicated urinary tract infections, Nadine Rouphael, Patricia Winokur, Michael C. Keefer, Jessica Traenkner, Ana Drobeniuc, Yohei Doi, Sonal Munsiff, Vance G. Fowler, Scott Evans, Randolph E. Oler, Bonifride Tuyishimire, Marina Lee, Varduhi Ghazaryan, and Henry F. Chambers

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Desirability Of Outcome Ranking (DOOR) for Obstetric Trials: Illustration and Application to the ARRIVE Trial, Grecio J. Sandoval, William A. Grobman, Scott R. Evans, Madeline M. Rice, Rebecca G. Clifton, Suneet P. Chauhan, Maged M. Costantine, Kelly S. Gibson, Monica Longo, Torri D. Metz, Emily S. Miller, Samuel Parry, Uma M. Reddy, Dwight J. Rouse, Hyagriv N. Simhan, John M. Thorp, Alan T. Tita, and George R. Saade

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Priorities and Progress in Gram-negative Bacterial Infection Research by the Antibacterial Resistance Leadership Group, Michael J. Satlin, David van Duin, Pranita D. Tamma, Thomas P. Lodise, Daria Van Tyne, Keith A. Rodvold, Nadine Rouphael, Scott R. Evans, Vance G. Fowler, Toshimitsu Hamasaki, Robin Patel, Lauren Komarow, Keri Baum, Maria Souli, Nyssa Schwager, Robert A. Bonomo, and Yohei Doi

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Assessment of Circulating Insulin Using Mass Spectrometry During Insulin Glargine Treatment in Type 2 Diabetes: Implications for Estimating Insulin Sensitivity and β-cell Function, Jesse C. Seegmiller, David J. Schmit, Valerie L. Arends, Michael W. Steffes, Steven E. Kahn, and Naji Younes

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Nasopharyngeal fungal subtypes of infant bronchiolitis and disease severity risk, Ryohei Shibata, Zhaozhong Zhu, Michihito Kyo, Tadao Ooka, Robert J. Freishtat, Jonathan M. Mansbach, Marcos Pérez-Losada, Carlos A. Camargo, and Kohei Hasegawa

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Diabetes Risk Factors and Bone Microarchitecture as Assessed by High-Resolution Peripheral Quantitative Computed Tomography in Adults With Long-Standing Type 1 Diabetes, Naina Sinha Gregory, Andrew J. Burghardt, Jye-Yu C. Backlund, Mishaela R. Rubin, Ionut Bebu, Barbara H. Braffett, David J. Kenny, Thomas M. Link, Galateia J. Kazakia, Annette Barnie, John M. Lachin, Rose Gubitosi-Klug, Ian H. de Boer, and Ann V. Schwartz

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Comparison of three rapid diagnostic tests for bloodstream infections using Benefit-risk Evaluation Framework (BED-FRAME), Richard D. Smith, Min Zhan, Shanshan Zhang, Surbhi Leekha, Anthony Harris, Yohei Doi, Scott Evans, J Kristie Johnson, and Robert K. Ernst

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Abnormalities in intron retention characterize patients with systemic lupus erythematosus, Xiaoqian Sun, Zhichao Liu, Zongzhu Li, Zhouhao Zeng, Weiqun Peng, Jun Zhu, Joel Zhao, Chenghao Zhu, Chen Zeng, Nathaniel Stearrett, Keith A. Crandall, Prathyusha Bachali, Amrie C. Grammer, and Peter E. Lipsky

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Consumption of sucralose- and acesulfame-potassium-containing diet soda alters the relative abundance of microbial taxa at the species level: findings of two pilot studies, Allison C. Sylvetsky, Rebecca A. Clement, Nathaniel Stearrett, Najy T. Issa, Fiona J. Dore, Raja Mazumder, Charles Hadley King, Monica J. Hubal, Peter J. Walter, Hongyi Cai, Sabyasachi Sen, Kristina I. Rother, and Keith A. Crandall

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Cost-effectiveness of ticagrelor plus aspirin versus aspirin in acute ischaemic stroke or transient ischaemic attack: an economic evaluation of the THALES trial, Amarjeet Tank, S Claiborne Johnston, Ritika Jain, Pierre Amarenco, Carl Mellström, Klas Rikner, Hans Denison, Per Ladenvall, Mikael Knutsson, Anders Himmelmann, Scott R. Evans, Stefan James, Carlos A. Molina, Yongjun Wang, and Mario Ouwens

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Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection, Tanayott Thaweethai, Sarah E. Jolley, Elizabeth W. Karlson, Emily B. Levitan, Bruce Levy, Grace A. McComsey, Lisa McCorkell, Girish N. Nadkarni, Sairam Parthasarathy, Upinder Singh, Tiffany A. Walker, Caitlin A. Selvaggi, Daniel J. Shinnick, Carolin C. Schulte, Rachel Atchley-Challenner, George A. Alba, Radica Alicic, Natasha Altman, Khamal Anglin, Urania Argueta, Hassan Ashktorab, Gaston Baslet, Ingrid V. Bassett, Lucinda Bateman, Brahmchetna Bedi, Shamik Bhattacharyya, Marie-Abele Bind, Andra L. Blomkalns, Hector Bonilla, Patricia A. Bush, Mario Castro, and James Chan

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PROMPT: Prospective Meta-analysis for Pessary Trials Study Protocol, Elizabeth A. Thom, George R. Saade, Lisa M. Askie, Lynda G. Ugwu, Ben W. Mol, Christophe Vayssiere, Jane E. Norman, Eva Pajkrt, Rebecca G. Clifton, Joseph R. Biggio, Catherine Arnaud, Vincenzo Berghella, Maria G. Canino, Elena Carreras, Lorraine Dugoff, Matthew K. Hoffman, Rodolfo C. Pacagnella, Uma M. Reddy, Gabriele Saccone, Janneke van Hooft, and Vinh Q. Dang

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Psychosocial Factors Predicting Healthcare Usage in Young Adults with Youth-Onset Type 2 Diabetes: The TODAY2 iCount Observational Study, Paula M. Trief, Diane Uschner, Barbara J. Anderson, Hui Wen, Jane D. Bulger, and Ruth S. Weinstock

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Psychosocial factors predict medication adherence in young adults with youth-onset type 2 diabetes: Longitudinal results from the TODAY2 iCount study, Paula M. Trief, Diane Uschner, Seth Kalichman, Barbara J. Anderson, Lida M. Fette, Hui Wen, Jane D. Bulger, and Ruth S. Weinstock

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Impact of youth onset type 2 diabetes during pregnancy on microvascular and cardiac outcomes, Jeanie B. Tryggestad, Kimberly L. Drews, Lisa Mele, Silva Arslanian, Steven D. Chernausek, Elia N. Escaname, Mitchell Geffner, Elvira Isganaitis, Jennifer Sprague, and Megan M. Kelsey

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Genetic Predisposition to Adverse Neurodevelopmental Outcome of Extremely Low Birth Weight Infants, Michael W. Varner, Elizabeth A. Thom, C Michael Cotten, Susan R. Hintz, Grier P. Page, Dwight J. Rouse, Brian M. Mercer, Maged M. Costantine, Yoram Sorokin, John M. Thorp, Susan M. Ramin, Marshall W. Carpenter, Mary J. O'Sullivan, Alan M. Peaceman, George R. Saade, Donald J. Dudley, and Steve N. Caritis

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Clinical Outcomes and Bacterial Characteristics of Carbapenem-Resistant Acinetobacter baumannii Among Patients from Different Global Regions, Minggui Wang, Lizhao Ge, Liang Chen, Lauren Komarow, Blake Hanson, Jinnethe Reyes, Eric Cober, Thamer Alenazi, Zhiyong Zong, Qing Xie, Zhengyin Liu, Lanjuan Li, Yunsong Yu, Hainv Gao, Souha S. Kanj, Jairo Figueroa, Erica Herc, Ezequiel Cordova, Gregory Weston, Paul Ananth Tambyah, Julia Garcia-Diaz, Keith S. Kaye, Sorabh Dhar, Jose M. Munita, Robert A. Salata, Samuel Vilchez, Martin E. Stryjewski, Maria Virginia Villegas Botero, Alina Iovleva, Scott Evans, Keri Baum, and Carol Hill

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Comparative Effects of Glucose-Lowering Medications on Kidney Outcomes in Type 2 Diabetes: The GRADE Randomized Clinical Trial, Deborah J. Wexler, Ian H. de Boer, Alokananda Ghosh, Naji Younes, Ionut Bebu, Silvio E. Inzucchi, Janet B. McGill, Sunder Mudaliar, David Schade, Michael W. Steffes, William V. Tamborlane, Meng H. Tan, and Faramarz Ismail-Beigi

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Comparative Effects of Glucose-Lowering Medications on Kidney Outcomes in Type 2 Diabetes: The GRADE Randomized Clinical Trial, Deborah J. Wexler, Ian H. de Boer, Alokananda Ghosh, Naji Younes, Ionut Bebu, Silvio E. Inzucchi, Janet B. McGill, Sunder Mudaliar, David Schade, Michael W. Steffes, William V. Tamborlane, Meng H. Tan, and Faramarz Ismail-Beigi

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Convergent adaptation of true crabs (Decapoda: Brachyura) to a gradient of terrestrial environments, Joanna M. Wolfe, Lauren Ballou, Javier Luque, Victoria M. Watson-Zink, Shane T. Ahyong, Joëlle Barido-Sottani, Tin-Yam Chan, Ka Hou Chu, Keith A. Crandall, Savel R. Daniels, Darryl L. Felder, Harrison Mancke, Joel W. Martin, Peter K. Ng, Javier Ortega-Hernández, Emma Palacios Theil, N Dean Pentcheff, Rafael Robles, Brent P. Thoma, Ling Ming Tsang, Regina Wetzer, Amanda M. Windsor, and Heather D. Bracken-Grissom

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Amphibian myelopoiesis, Amulya Yaparla, David B. Stern, Muhammad Riadul Hossainey, Keith A. Crandall, and Leon Grayfer

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Which Trial Do We Need? Optimal Antibiotic Duration for Patients with Sepsis, Christina Yek, Alexander Lawandi, Scott R. Evans, and Sameer S. Kadri

Submissions from 2022

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Composition, Structure and Diversity of Soil Bacterial Communities before, during and after Transit through the Gut of the Earthworm, Manuel Aira, Marcos Pérez-Losada, Keith A. Crandall, and Jorge Domínguez

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Host taxonomy determines the composition, structure, and diversity of the earthworm cast microbiome under homogenous feeding conditions, Manuel Aira, Marcos Pérez-Losada, Keith A. Crandall, and Jorge Domínguez

Dominant clade-featured SARS-CoV-2 co-occurring mutations reveal plausible epistasis: An in silico based hypothetical model, A. S.M.Rubayet Ul Alam, Ovinu Kibria Islam, Md Shazid Hasan, Mir Raihanul Islam, Shafi Mahmud, Hassan M. Al-Emran, Iqbal Kabir Jahid, Keith A. Crandall, and M. Anwar Hossain

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Corrigendum to "The cross-sectional association of renal dysfunction with tests of cognition in middle-aged adults with early type 2 diabetes The GRADE Study" [J. Diabetes Complicat., 35 (3) (2021) 107805], Joshua I. Barzilay, Naji Younes, Rodica Pop-Busui, Hermes Florez, Elizabeth Seaquist, Corinna Falck-Ytter, and Jose A. Luchsinger

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Mechanism of neonatal hypoglycemia after late preterm steroids: are fetal metabolic effects responsible?, Ashley N. Battarbee, Grecio J. Sandoval, Cynthia Gyamfi-Bannerman, Sean C. Blackwell, Alan T. Tita, Uma M. Reddy, and Lucky Jain

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Relationships Between the Cumulative Incidences of Long-term Complications in Type 1 Diabetes: the DCCT/EDIC Study, Ionut Bebu, Barbara H. Braffett, Ian H. de Boer, Lloyd P. Aiello, John P. Bantle, Gayle M. Lorenzi, William H. Herman, Rose A. Gubitosi-Klug, Bruce A. Perkins, John M. Lachin, and Mark E. Molitch

Why sequence all eukaryotes?, Mark Blaxter, John M. Archibald, Anna K. Childers, Jonathan A. Coddington, Keith A. Crandall, Federica Di Palma, Richard Durbin, Scott V. Edwards, Jennifer A.M. Graves, Kevin J. Hackett, Neil Hall, Erich D. Jarvis, Rebecca N. Johnson, Elinor K. Karlsson, W. John Kress, Shigehiro Kuraku, Mara K.N. Lawniczak, Kerstin Lindblad-Toh, Jose V. Lopez, Nancy A. Moran, Gene E. Robinson, Oliver A. Ryder, Beth Shapiro, Pamela S. Soltis, Tandy Warnow, Guojie Zhang, and Harris A. Lewin

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Comparison of ETDRS 7-Field to 4-Widefield Digital Imaging in the Evaluation of Diabetic Retinopathy Severity, Barbara A. Blodi, Amitha Domalpally, Ashley H. Tjaden, Nancy Barrett, Emily Y. Chew, William C. Knowler, Christine G. Lee, Xavier Pi-Sunyer, Amisha Wallia, Neil H. White, and Marinella Temprosa

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Islet Autoimmunity is Highly Prevalent and Associated With Diminished β-Cell Function in Patients With Type 2 Diabetes in the Grade Study, Barbara Brooks-Worrell, Christiane S. Hampe, Erica G. Hattery, Brenda Palomino, Sahar Z. Zangeneh, Kristina Utzschneider, Steven E. Kahn, Mary E. Larkin, Mary L. Johnson, Kieren J. Mather, Naji Younes, Neda Rasouli, Cyrus Desouza, Robert M. Cohen, Jean Y. Park, Hermes J. Florez, and Willy Marcos Valencia

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Frailty and Depression in Late Life: A High-Risk Comorbidity With Distinctive Clinical Presentation and Poor Antidepressant Response, Patrick J. Brown, Adam Ciarleglio, Steven P. Roose, Carolina Montes Garcia, Sarah Chung, Sara Fernandes, and Bret R. Rutherford

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Impact of Fecal Microbiota Transplantation on Gut Bacterial Bile Acid Metabolism in Humans, Jessica-Miranda Bustamante, Tyson Dawson, Caitlin Loeffler, Zara Marfori, Julian R. Marchesi, Benjamin H. Mullish, Christopher C. Thompson, Keith A. Crandall, Ali Rahnavard, Jessica R. Allegretti, and Bethany P. Cummings

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A doubly robust method to handle missing multilevel outcome data with application to the China Health and Nutrition Survey., Nicole M. Butera, Donglin Zeng, Annie Green Howard, Penny Gordon-Larsen, and Jianwen Cai

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Self-reported mask use among persons with or without SARS CoV-2 vaccination -United States, December 2020-August 2021, Lydia E. Calamari, Ashley H. Tjaden, Sharon L. Edelstein, William S. Weintraub, Roberto Santos, Michael Gibbs, Johnathan Ward, Michele Santacatterina, Alain G. Bertoni, Lori M. Ward, Sharon Saydah, Ian D. Plumb, and Michael S. Runyon

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Weight gain trajectories and obesity rates in intensive and conventional treatments of type 1 diabetes from the DCCT compared with a control population without diabetes, Nichole E. Carlson, Ken W. Horton, John E. Hokanson, Patricia A. Cleary, David R. Jacobs, John D. Brunzell, and Jonathan Q. Purnell

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Association of Body Mass Index With the Use of Health Care Resources in Low-Risk Nulliparous Pregnancies After 39 Weeks of Gestation, Maged M. Costantine, Grecio J. Sandoval, William A. Grobman, Uma M. Reddy, Alan T. Tita, Robert M. Silver, Yasser Y. El-Sayed, Ronald J. Wapner, Dwight J. Rouse, George R. Saade, John M. Thorp, Suneet P. Chauhan, Edward K. Chien, Brian M. Casey, Sindhu K. Srinivas, Geeta K. Swamy, and Hyagriv N. Simhan

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Synthesizing studies for comparing different treatment sequences in clinical trials, Guoqing Diao, Haijun Ma, Donglin Zeng, Chunlei Ke, and Joseph G. Ibrahim

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Guest editors' note on the special issue International Chinese Statistical Association (ICSA) Applied Statistics Symposium 2021, Guoqing Diao, Lu Mao, Fang Jin, and Junjing Lin

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Amniocentesis to diagnose congenital cytomegalovirus infection following maternal primary infection, Mara J. Dinsmoor, Lida M. Fette, Brenna L. Hughes, Dwight J. Rouse, George R. Saade, Uma M. Reddy, Donna Allard, Gail Mallett, Elizabeth A. Thom, Cynthia Gyamfi-Bannerman, Michael W. Varner, William H. Goodnight, Alan T. Tita, Maged M. Costantine, Geeta K. Swamy, Kent D. Heyborne, Edward K. Chien, Suneet P. Chauhan, Yasser Y. El-Sayed, Brian M. Casey, Samuel Parry, Hyagriv N. Simhan, Peter G. Napolitano, and George A. Macones

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Classification Performance and Feature Space Characteristics in Individuals With Upper Limb Loss Using Sonomyography., Susannah Engdahl, Ananya Dhawan, Ahmed Bashatah, Guoqing Diao, Biswarup Mukherjee, Brian Monroe, Rahsaan Holley, and Siddhartha Sikdar

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Response to Loewenthal et al, Scott Evans

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Weighing Evidence: Robustness vs Quantity, Scott R. Evans and Toshimitsu Hamasaki

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Differences in complications, cardiovascular risk factor, and diabetes management among participants enrolled at veterans affairs (VA) and non-VA medical centers in the glycemia reduction approaches in diabetes: A comparative effectiveness study (GRADE)., Hermes J Florez, Alokananda Ghosh, Rodica Pop-Busui, Sophia H Hox, Chantal Underkofler, M Diane McKee, Jean Park, Mary K Rhee, Tina Killean, Heidi Krause-Steinrauf, Vanita R Aroda, and Deborah J Wexler

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A Dynamic Risk Model for Multitype Recurrent Events, Alokananda Ghosh, Wenyaw Chan, Naji Younes, and Barry R. Davis

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Emotional Distress, Self-Management, and Glycemic Control among Participants enrolled in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness (GRADE) Study, Jeffrey S. Gonzalez, Heidi Krause-Steinrauf, Ionut Bebu, Gladys Crespo-Ramos, Claire J. Hoogendoorn, Aanand D. Naik, Andrea Waltje, Elizabeth Walker, Dominic Ehrmann, Janet Brown-Friday, and Andrea Cherrington

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Source and acquisition of rhizosphere microbes in Antarctic vascular plants, Sergio Guajardo-Leiva, Jaime Alarcón, Florence Gutzwiller, Jorge Gallardo-Cerda, Ian S. Acuña-Rodríguez, Marco Molina-Montenegro, Keith A. Crandall, Marcos Pérez-Losada, and Eduardo Castro-Nallar

[Multiple Endpoints in Oncology Clinical Trials], Toshimitsu Hamasaki and Frank Bretz

[What Is an Estimand?-The Most Important Clinical Question in Oncology Trials], Toshimitsu Hamasaki and Frank Bretz

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ZnT8 autoantibody prevalence is low in youth with type 2 diabetes and associated with higher insulin sensitivity, lower insulin secretion, and lower disposition index, Janine Higgins, Philip Zeitler, Kimberly L. Drews, Silva Arslanian, Kenneth Copeland, Robin Goland, Georgeanna Klingensmith, Terri H. Lipman, and Sherida Tollefsen

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Induction of mastitis by cow-to-mouse fecal and milk microbiota transplantation causes microbiome dysbiosis and genomic functional perturbation in mice, M Nazmul Hoque, M Shaminur Rahman, Tofazzal Islam, Munawar Sultana, Keith A. Crandall, and M Anwar Hossain

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A Desirability of Outcome Ranking Analysis of a Randomized Clinical Trial Comparing Seven Versus Fourteen Days of Antibiotics for Uncomplicated Gram-Negative Bloodstream Infection, Jessica Howard-Anderson, Weixiao Dai, Dafna Yahav, Toshimitsu Hamasaki, Adi Turjeman, Fidi Koppel, Erica Franceschini, Carol Hill, Zoë Sund, Henry F. Chambers, Vance G. Fowler, Helen W. Boucher, Scott R. Evans, Mical Paul, Thomas L. Holland, and Sarah B. Doernberg

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Improving Traditional Registrational Trial Endpoints: Development and Application of a Desirability of Outcome Ranking (DOOR) Endpoint for Complicated Urinary Tract Infection Clinical Trials, Jessica Howard-Anderson, Toshimitsu Hamasaki, Weixiao Dai, Deborah Collyar, Daniel Rubin, Sumathi Nambiar, Tori Kinamon, Carol Hill, Steven P. Gelone, David Mariano, Takamichi Baba, Thomas L. Holland, Sarah B. Doernberg, Henry F. Chambers, Vance G. Fowler, Scott R. Evans, and Helen W. Boucher

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First or second trimester SARS-CoV-2 infection and subsequent pregnancy outcomes, Brenna L. Hughes, Grecio J. Sandoval, Torri D. Metz, Rebecca G. Clifton, William A. Grobman, George R. Saade, Tracy A. Manuck, Monica Longo, Amber Sowles, Kelly Clark, Hyagriv N. Simhan, Dwight J. Rouse, Hector Mendez-Figueroa, Cynthia Gyamfi-Bannerman, Jennifer Bailit, Maged M. Costantine, Harish M. Sehdev, Alan T. Tita, and George A. Macones

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Mixture survival trees for cancer risk classification, Beilin Jia, Donglin Zeng, Jason J. Liao, Guanghan F. Liu, Xianming Tan, Guoqing Diao, and Joseph G. Ibrahim

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Mediational Effects on Motivation to Quit Smoking After Exposure to a Cigarette Pictorial Warning Label Among Young Adults, Andrea C. Johnson, Monique M. Turner, Samuel J. Simmens, W Douglas Evans, Andrew A. Strasser, and Darren Mays

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Unlocking capacities of genomics for the COVID-19 response and future pandemics, Sergey Knyazev, Karishma Chhugani, Varuni Sarwal, Ram Ayyala, Harman Singh, Smruthi Karthikeyan, Dhrithi Deshpande, Pelin Icer Baykal, Zoia Comarova, Angela Lu, Yuri Porozov, Tetyana I. Vasylyeva, Joel O. Wertheim, Braden T. Tierney, Charles Y. Chiu, Ren Sun, Aiping Wu, Malak S. Abedalthagafi, Victoria M. Pak, Shivashankar H. Nagaraj, Adam L. Smith, Pavel Skums, Bogdan Pasaniuc, Andrey Komissarov, Christopher E. Mason, Eric Bortz, Philippe Lemey, Fyodor Kondrashov, Niko Beerenwinkel, Tommy Tsan-Yuk Lam, Nicholas C. Wu, and Alex Zelikovsky

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Prospective Validation of a Rapid Host Gene Expression Test to Discriminate Bacterial From Viral Respiratory Infection, Emily R. Ko, Ricardo Henao, Katherine Frankey, Elizabeth A. Petzold, Pamela D. Isner, Anja K. Jaehne, Nakia Allen, Jayna Gardner-Gray, Gina Hurst, Jacqueline Pflaum-Carlson, Namita Jayaprakash, Emanuel P. Rivers, Henry Wang, Irma Ugalde, Siraj Amanullah, Laura Mercurio, Thomas H. Chun, Larissa May, Robert W. Hickey, Jacob E. Lazarus, Shauna H. Gunaratne, Daniel J. Pallin, Guruprasad Jambaulikar, David S. Huckins, Krow Ampofo, Ravi Jhaveri, Yunyun Jiang, Lauren Komarow, Scott R. Evans, Geoffrey S. Ginsburg, L Gayani Tillekeratne, and Micah T. McClain

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Early initiation of rivaroxaban after reperfusion therapy for stroke patients with nonvalvular atrial fibrillation, Junpei Koge, Hiroshi Yamagami, Kazunori Toyoda, Masahiro Yasaka, Teruyuki Hirano, Toshimitsu Hamasaki, Takehiko Nagao, Shinichi Yoshimura, Masahito Fujishige, Akira Tempaku, Shinichiro Uchiyama, Etsuro Mori, Masatoshi Koga, and Kazuo Minematsu

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Effect of anterior approach compared to posterolateral approach on readiness for discharge and thrombogenic markers in patients undergoing unilateral total hip arthroplasty: a prospective cohort study, Kyle N. Kunze, Alexander S. McLawhorn, Kethy M. Jules-Elysee, Michael M. Alexiades, Natasha A. Desai, Yi Lin, Jonathan C. Beathe, Yan Ma, Wei Zhang, and Thomas P. Sculco

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Gastrointestinal Microbiome Disruption and Antibiotic-Associated Diarrhea in Children Receiving Antibiotic Therapy for Community-Acquired Pneumonia, J Kwon, Y Kong, M Wade, D J. Williams, C B. Creech, S Evans, E B. Walter, J M. Martin, J S. Gerber, J G. Newland, M E. Hofto, M A. Staat, H F. Chambers, V G. Fowler, W C. Huskins, and M M. Pettigrew

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Association of Estimated Time-in-Range Capillary Glucose Levels Versus HbA1c With Progression of Microvascular Complications in the Diabetes Control and Complications Trial, John M. Lachin, Ionut Bebu, Xiaoyu Gao, David M. Nathan, and Bernard Zinman

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The effects of betamethasone on the amplitude integrated EEG of infants born at 34- or 35-weeks gestation, Abbot R. Laptook, Lina Chalak, Athina Pappas, Alexis Davis, Pablo J. Sanchez, Krisa P. Van Meurs, William Oh, Ross Sommers, Seetha Shankaran, Angelita M. Hensman, Dwight J. Rouse, Scott McDonald, Abhik Das, Ronald N. Goldberg, Namasivayam Ambalavanan, Cynthia Gyamfi-Bannerman, Elizabeth A. Thom, and Rosemary D. Higgins

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The obesity paradox: Retinopathy, obesity, and circulating risk markers in youth with type 2 diabetes in the TODAY Study, Lynne L. Levitsky, Kimberly L. Drews, Morey Haymond, Rose A. Glubitosi-Klug, Lorraine E. Levitt Katz, Mihai Mititelu, William Tamborlane, Jeanie B. Tryggestad, and Ruth S. Weinstock

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The Earth BioGenome Project 2020: Starting the clock., Harris A Lewin, Stephen Richards, Erez Lieberman Aiden, Miguel L Allende, John M Archibald, Miklós Bálint, Katharine B Barker, Bridget Baumgartner, Katherine Belov, Giorgio Bertorelle, Mark L Blaxter, Jing Cai, Nicolette D Caperello, Keith Carlson, Juan Carlos Castilla-Rubio, Shu-Miaw Chaw, Lei Chen, Anna K Childers, Jonathan A Coddington, Dalia A Conde, Montserrat Corominas, Keith A. Crandall, Andrew J Crawford, Federica DiPalma, Richard Durbin, ThankGod E Ebenezer, Scott V Edwards, Olivier Fedrigo, Paul Flicek, Giulio Formenti, Richard A Gibbs, M Thomas P Gilbert, Melissa M. Goldstein, Jennifer Marshall Graves, Henry T Greely, Igor V Grigoriev, Kevin J Hackett, Neil Hall, David Haussler, Kristofer M Helgen, Carolyn J Hogg, Sachiko Isobe, Kjetill Sigurd Jakobsen, Axel Janke, Erich D Jarvis, Warren E Johnson, Steven J M Jones, Elinor K Karlsson, Paul J Kersey, Jin-Hyoung Kim, W John Kress, Shigehiro Kuraku, Mara K N Lawniczak, James H Leebens-Mack, Xueyan Li, Kerstin Lindblad-Toh, Xin Liu, Jose V Lopez, Tomas Marques-Bonet, Sophie Mazard, Jonna A K Mazet, Camila J Mazzoni, Eugene W Myers, Rachel J O'Neill, Sadye Paez, Hyun Park, Gene E Robinson, Cristina Roquet, Oliver A Ryder, Jamal S M Sabir, H Bradley Shaffer, Timothy M Shank, Jacob S Sherkow, Pamela S Soltis, Boping Tang, Leho Tedersoo, Marcela Uliano-Silva, Kun Wang, Xiaofeng Wei, Regina Wetzer, Julia L Wilson, Xun Xu, Huanming Yang, Anne D Yoder, and Guojie Zhang

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Differential expression of single-cell RNA-seq data using Tweedie models, Himel Mallick, Suvo Chatterjee, Shrabanti Chowdhury, Saptarshi Chatterjee, Ali Rahnavard, and Stephanie C. Hicks

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Retinopathy During the First 5 Years of Type 1 Diabetes and Subsequent Risk of Advanced Retinopathy, John I. Malone, Xiaoyu Gao, Gayle M. Lorenzi, Philip Raskin, Neil H. White, Dean P. Hainsworth, Arup Das, William Tamborlane, Amisha Wallia, Lloyd P. Aiello, and Ionut Bebu

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Physical Function in Middle-aged and Older Adults With Type 1 Diabetes: Long-term Follow-up of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study, Catherine L. Martin, Victoria R. Trapani, Jye-Yu C. Backlund, Pearl Lee, Barbara H. Braffett, Ionut Bebu, John M. Lachin, Alan M. Jacobson, Rose Gubitosi-Klug, and William H. Herman

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Retinal Thickness and Morphology Changes on OCT in Youth with Type 2 Diabetes: Findings from the TODAY Study, Mihai Mititelu, Diane Uschner, Lindsay Doherty, Petter Bjornstad, Amitha Domalpally, Kimberly L. Drews, Rose Gubitosi-Klug, Lynne L. Levitsky, Jeong W. Pak, Neil H. White, and Barbara A. Blodi

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Association of Obesity and Diabetes with SARS-Cov-2 Infection and Symptoms in the COVID-19 Community Research Partnership, Morgana Mongraw-Chaffin, Ashley Hogan Tjaden, Austin Lyles Seals, Kristen Miller, Naheed Ahmed, Mark A. Espeland, Michael Gibbs, Dorey Thomas, Diane Uschner, William S. Weintraub, and Sharon L. Edelstein

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Plasma advanced glycation end products and the subsequent risk of microvascular complications in type 1 diabetes in the DCCT/EDIC, Vincent M. Monnier, David R. Sell, Xiaoyu Gao, Saul M. Genuth, John M. Lachin, and Ionut Bebu

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An evaluation of seasonal maternal-neonatal morbidity related to trainee cycles, Ayamo Oben, Paula McGee, William A. Grobman, Jennifer L. Bailit, Ronald J. Wapner, Michael W. Varner, John M. Thorp, Steve N. Caritis, Mona Prasad, George R. Saade, Dwight J. Rouse, and Sean C. Blackwell

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Intravenous Ketamine for Late-Life Treatment-Resistant Depression: A Pilot Study of Tolerability, Safety, Clinical Benefits, and Effect on Cognition, Hanadi Ajam Oughli, Marie Anne Gebara, Adam Ciarleglio, Helen Lavretsky, Patrick J. Brown, Alastair J. Flint, Nuri B. Farber, Jordan F. Karp, Benoit H. Mulsant, Charles F. Reynolds, Steven P. Roose, Lei Yang, Meryl A. Butters, and Eric J. Lenze

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Clinically Adjudicated Reference Standards for Evaluation of Infectious Diseases Diagnostics, Robin Patel, Ephraim L. Tsalik, Scott Evans, Vance G. Fowler, and Sarah B. Doernberg

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PREDICITION OF CEREBRAL PALSY OR DEATH AMONG PRETERM INFANTS WHO SURVIVE THE NEONATAL PERIOD, Alan Peaceman, Lisa Mele, Dwight J. Rouse, Kenneth J. Leveno, Brian Mercer, Michael Varner, Uma M. Reddy, Ronald Wapner, Yoram Sorokin, John M. Thorp, Susan Ramin, Fergal Malone, Mary J. O'Sullivan, Donald J. Dudley, and Steve N. Caritis

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Reef Location and Client Diversity Influence the Skin Microbiome of the Caribbean Cleaner Goby Elacatinus evelynae, Ana Pereira, Marta C. Soares, Teresa Santos, Ana Poças, Marcos Pérez-Losada, Amy Apprill, Paul C. Sikkel, and Raquel Xavier

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Comparative Analysis of Metagenomics and Metataxonomics for the Characterization of Vermicompost Microbiomes, Marcos Pérez-Losada, Dhatri Badri Narayanan, Allison R. Kolbe, Ignacio Ramos-Tapia, Eduardo Castro-Nallar, Keith A. Crandall, and Jorge Domínguez

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Optimal Frequency of Urinary Albumin Screening in Type 1 Diabetes, Bruce A. Perkins, Ionut Bebu, Ian H. de Boer, Mark Molitch, Bernard Zinman, John Bantle, Gayle M. Lorenzi, David M. Nathan, and John M. Lachin

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Early Trajectory of Estimated Glomerular Filtration Rate and Long-term Advanced Kidney and Cardiovascular Complications in Type 1 Diabetes, Bruce A. Perkins, Ionut Bebu, Xiaoyu Gao, Amy B. Karger, Irl B. Hirsch, Harsha Karanchi, Mark E. Molitch, Bernard Zinman, John M. Lachin, and Ian H. de Boer

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Metabolite, protein, and tissue dysfunction associated with COVID-19 disease severity, Ali Rahnavard, Brendan Mann, Abhigya Giri, Ranojoy Chatterjee, and Keith A. Crandall

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Monitoring Infection and Antibiotic Treatment in the Skin Microbiota of Farmed European Seabass (Dicentrarchus Labrax) Fingerlings, Daniela Rosado, Marcos Pérez-Losada, Ricardo Severino, and Raquel Xavier

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Biochemical Markers of Bone Turnover in Older Adults with Type 1 Diabetes, Mishaela R. Rubin, Ian H. de Boer, Jye-Yu C. Backlund, Valerie Arends, Rose Gubitosi-Klug, Amisha Wallia, Naina Sinha Gregory, Annette Barnie, Andrew J. Burghardt, John M. Lachin, Barbara H. Braffett, and Ann V. Schwartz

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Cost-Efficient Multiply Matched Case-Control Study Designs, Grecio J. Sandoval, Ionut Bebu, and John M. Lachin

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Risk factors for lower bone mineral density in older adults with type 1 diabetes: a cross-sectional study, Ann V. Schwartz, Jye-Yu C. Backlund, Ian H. de Boer, Mishaela R. Rubin, Annette Barnie, Kaleigh Farrell, Victoria R. Trapani, Naina Sinha Gregory, Amisha Wallia, Ionut Bebu, John M. Lachin, Barbara H. Braffett, and Rose Gubitosi-Klug

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Relationship between Arterial Stiffness and Subsequent Cardiac Structure and Function in Young Adults with Youth-Onset Type 2 Diabetes: Results from the TODAY Study, Amy S. Shah, Samuel S. Gidding, Laure El ghormli, Jeanie B. Tryggestad, Kristen J. Nadeau, Fida Bacha, Lorraine E. Levitt Katz, Steven M. Willi, Joao Lima, and Elaine M. Urbina

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Circulating microRNAs in cellular and antibody-mediated heart transplant rejection, Palak Shah, Sean Agbor-Enoh, Pramita Bagchi, Christopher R. deFilippi, Angela Mercado, Gouqing Diao, Dave Jp Morales, Keyur B. Shah, Samer S. Najjar, Erika Feller, Steven Hsu, Maria E. Rodrigo, Sabra C. Lewsey, Moon Kyoo Jang, Charles Marboe, Gerald J. Berry, Kiran K. Khush, and Hannah A. Valantine

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Maternal Diabetes in Youth-Onset Type 2 Diabetes Is Associated with Progressive Dysglycemia and Risk of Complications, Rachana D. Shah, Steven D. Chernausek, Laure El Ghormli, Mitchell E. Geffner, Joyce Keady, Megan M. Kelsey, Ryan Farrell, Bereket Tesfaldet, Jeanie B. Tryggestad, Michelle Van Name, and Elvira Isganaitis