Epicardial and intra-thoracic adipose tissue and cardiovascular calcifications in type 1 diabetes (T1D) in epidemiology of diabetes Interventions and Complications (EDIC): A pilot study
Document Type
Journal Article
Publication Date
6-1-2024
Journal
American journal of preventive cardiology
Volume
18
DOI
10.1016/j.ajpc.2024.100650
Keywords
Adipose tissue; Calcification; Coronary; Epicardial; Intra-thoracic; Type 1 Diabtes Melitus
Abstract
OBJECTIVE: Coronary artery, aortic valve, and descending aorta calcification (CAC, AVC, DAC) are manifestations of atherosclerosis, and cardiac epicardial adipose tissue (EAT) indicates heart adiposity. This study explored the association between cardiac adipose tissue and cardiovascular calcification in participants with long-standing T1D. METHODS: EAT and intra-thoracic adipose tissue (IAT) were measured in 100 T1D subjects with cardiac computed tomography (CT) scans in the EDIC study. Volume analysis software was used to measure fat volumes. Spearman correlations were calculated between CAC, AVC, DAC with EAT, and IAT. Associations were evaluated using multiple linear and logistic regression models. RESULTS: Participants ranged in age from 32 to 57. Mean EAT, and IAT were 38.5 and 50.8 mm, respectively, and the prevalence of CAC, AVC, and DAC was 43.6 %, 4.7 %, and 26.8 %, respectively. CAC was positively correlated with age (-value = 0.0001) and EAT (-value = 0.0149) but not with AVC and DAC; IAT was not associated with calcified lesions. In models adjusted for age and sex, higher levels of EAT and IAT were associated with higher CAC (-value < 0.0001 for both) and higher AVC (-values of 0.0111 and 0.0053, respectively), but not with DAC. The associations with CAC remained significant (value < 0.0001) after further adjustment for smoking, systolic blood pressure, BMI, and LDL, while the associations with AVC did not remain significant. CONCLUSION: In participants with T1D, higher EAT and IAT levels are correlated with higher CAC scores. EAT and IAT were not independently correlated with DAC or AVC.
APA Citation
Rezaeian, Panteha; Backlund, Jye-Yu C.; Zaveri, Mohammed; Nakanishi, Rine; Matsumoto, Suguru; Alani, Anas; Razipour, Aryabod; Lachin, John M.; and Budoff, Matthew, "Epicardial and intra-thoracic adipose tissue and cardiovascular calcifications in type 1 diabetes (T1D) in epidemiology of diabetes Interventions and Complications (EDIC): A pilot study" (2024). GW Authored Works. Paper 5196.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/5196
Department
Biostatistics and Bioinformatics