Consumption of sucralose- and acesulfame-potassium-containing diet soda alters the relative abundance of microbial taxa at the species level: findings of two pilot studies

Authors

• Allison C. Sylvetsky, Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, The George Washington University, 950 New Hampshire Ave NW, Washington, DC 20052, USA.
• Rebecca A. Clement, Computational Biology Institute, Milken Institute School of Public Health, The George Washington University, 800 22nd Street NW, Science & Engineering Hall, Washington, DC 20052, USA.
• Nathaniel Stearrett, Computational Biology Institute, Milken Institute School of Public Health, The George Washington University, 800 22nd Street NW, Science & Engineering Hall, Washington, DC 20052, USA.
• Najy T. Issa, Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, The George Washington University, 950 New Hampshire Ave NW, Washington, DC 20052, USA.
• Fiona J. Dore, Department of Medicine, George Washington University School of Medicine, 2300 Eye Street NW, Washington, DC 20037, USA.
• Raja Mazumder, Department of Biochemistry, George Washington University School of Medicine, 2300 Eye Street NW, Washington, DC 20037, USA.
• Charles Hadley King, Department of Biochemistry, George Washington University School of Medicine, 2300 Eye Street NW, Washington, DC 20037, USA.
• Monica J. Hubal, Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, The George Washington University, 950 New Hampshire Ave NW, Washington, DC 20052, USA.
• Peter J. Walter, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 8C432A, Bethesda, MD 20892, USA.
• Hongyi Cai, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 8C432A, Bethesda, MD 20892, USA.
• Sabyasachi Sen, Department of Medicine, George Washington University School of Medicine, 2300 Eye Street NW, Washington, DC 20037, USA.
• Kristina I. Rother, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 8C432A, Bethesda, MD 20892, USA.
• Keith A. Crandall, Computational Biology Institute, Milken Institute School of Public Health, The George Washington University, 800 22nd Street NW, Science & Engineering Hall, Washington, DC 20052, USA.

Document Type

Journal Article

Publication Date

10-30-2023

Journal

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme

DOI

10.1139/apnm-2022-0471

Keywords

artificial sweeteners; diabetes; gut microbiota; low-calorie sweeteners; microbiome; obesity

Abstract

Sucralose and acesulfame-potassium consumption alters gut microbiota in rodents, with unclear effects in humans. We examined effects of three-times daily sucralose- and acesulfame-potassium-containing diet soda consumption for 1 ( = 17) or 8 ( = 8) weeks on gut microbiota composition in young adults. After 8 weeks of diet soda consumption, the relative abundance of Proteobacteria, specifically , increased; and, increased abundance of two Proteobacteria taxa was also observed after 1 week of diet soda consumption compared with sparkling water. In addition, three taxa in the genus increased following 1 week of diet soda consumption compared with sparkling water. The clinical relevance of these findings and effects of sucralose and acesulfame-potassium consumption on human gut microbiota warrant further investigation in larger studies. Clinical trial registration: NCT02877186 and NCT03125356.

APA Citation

Sylvetsky, Allison C.; Clement, Rebecca A.; Stearrett, Nathaniel; Issa, Najy T.; Dore, Fiona J.; Mazumder, Raja; King, Charles Hadley; Hubal, Monica J.; Walter, Peter J.; Cai, Hongyi; Sen, Sabyasachi; Rother, Kristina I.; and Crandall, Keith A., "Consumption of sucralose- and acesulfame-potassium-containing diet soda alters the relative abundance of microbial taxa at the species level: findings of two pilot studies" (2023). GW Authored Works. Paper 3540.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/3540

Department

Biostatistics and Bioinformatics