Consumption of sucralose- and acesulfame-potassium-containing diet soda alters the relative abundance of microbial taxa at the species level: findings of two pilot studies

Allison C. Sylvetsky, Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, The George Washington University, 950 New Hampshire Ave NW, Washington, DC 20052, USA.
Rebecca A. Clement, Computational Biology Institute, Milken Institute School of Public Health, The George Washington University, 800 22nd Street NW, Science & Engineering Hall, Washington, DC 20052, USA.
Nathaniel Stearrett, Computational Biology Institute, Milken Institute School of Public Health, The George Washington University, 800 22nd Street NW, Science & Engineering Hall, Washington, DC 20052, USA.
Najy T. Issa, Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, The George Washington University, 950 New Hampshire Ave NW, Washington, DC 20052, USA.
Fiona J. Dore, Department of Medicine, George Washington University School of Medicine, 2300 Eye Street NW, Washington, DC 20037, USA.
Raja Mazumder, Department of Biochemistry, George Washington University School of Medicine, 2300 Eye Street NW, Washington, DC 20037, USA.
Charles Hadley King, Department of Biochemistry, George Washington University School of Medicine, 2300 Eye Street NW, Washington, DC 20037, USA.
Monica J. Hubal, Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, The George Washington University, 950 New Hampshire Ave NW, Washington, DC 20052, USA.
Peter J. Walter, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 8C432A, Bethesda, MD 20892, USA.
Hongyi Cai, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 8C432A, Bethesda, MD 20892, USA.
Sabyasachi Sen, Department of Medicine, George Washington University School of Medicine, 2300 Eye Street NW, Washington, DC 20037, USA.
Kristina I. Rother, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 8C432A, Bethesda, MD 20892, USA.
Keith A. Crandall, Computational Biology Institute, Milken Institute School of Public Health, The George Washington University, 800 22nd Street NW, Science & Engineering Hall, Washington, DC 20052, USA.

Document Type

Journal Article

Publication Date

10-30-2023

Journal

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme

DOI

10.1139/apnm-2022-0471

Keywords

artificial sweeteners; diabetes; gut microbiota; low-calorie sweeteners; microbiome; obesity

Abstract

Sucralose and acesulfame-potassium consumption alters gut microbiota in rodents, with unclear effects in humans. We examined effects of three-times daily sucralose- and acesulfame-potassium-containing diet soda consumption for 1 ( = 17) or 8 ( = 8) weeks on gut microbiota composition in young adults. After 8 weeks of diet soda consumption, the relative abundance of Proteobacteria, specifically , increased; and, increased abundance of two Proteobacteria taxa was also observed after 1 week of diet soda consumption compared with sparkling water. In addition, three taxa in the genus increased following 1 week of diet soda consumption compared with sparkling water. The clinical relevance of these findings and effects of sucralose and acesulfame-potassium consumption on human gut microbiota warrant further investigation in larger studies. Clinical trial registration: NCT02877186 and NCT03125356.

Department

Biostatistics and Bioinformatics

Link to Full Text

Share

COinS