Priorities and Progress in Diagnostic Research by the Antibacterial Resistance Leadership Group

Authors

Kimberly E. Hanson, Division of Infectious Diseases, Department of Medicine, University of Utah, Salt Lake City, Utah, USA.
Ritu Banerjee, Division of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Sarah B. Doernberg, Division of Infectious Diseases, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
Scott R. Evans, Department of Biostatistics, George Washington University, Washington, DC, USA.
Lauren Komarow, George Washington University Biostatistics Center, Rockville, Maryland, USA.
Michael J. Satlin, Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, New York, USA.
Nyssa Schwager, Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA.
Patricia J. Simner, Division of Medical Microbiology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
L Gayani Tillekeratne, Division of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
Robin Patel, Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.

Document Type

Journal Article

Publication Date

10-16-2023

Journal

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Volume

77

Issue

Suppl 4

DOI

10.1093/cid/ciad541

Keywords

antibacterial resistance; bacterial infections; diagnostics

Abstract

The advancement of infectious disease diagnostics, along with studies devoted to infections caused by gram-negative and gram-positive bacteria, is a top scientific priority of the Antibacterial Resistance Leadership Group (ARLG). Diagnostic tests for infectious diseases are rapidly evolving and improving. However, the availability of rapid tests designed to determine antibacterial resistance or susceptibility directly in clinical specimens remains limited, especially for gram-negative organisms. Additionally, the clinical impact of many new tests, including an understanding of how best to use them to inform optimal antibiotic prescribing, remains to be defined. This review summarizes the recent work of the ARLG toward addressing these unmet needs in the diagnostics field and describes future directions for clinical research aimed at curbing the threat of antibiotic-resistant bacterial infections.

APA Citation

Hanson, Kimberly E.; Banerjee, Ritu; Doernberg, Sarah B.; Evans, Scott R.; Komarow, Lauren; Satlin, Michael J.; Schwager, Nyssa; Simner, Patricia J.; Tillekeratne, L Gayani; and Patel, Robin, "Priorities and Progress in Diagnostic Research by the Antibacterial Resistance Leadership Group" (2023). GW Authored Works. Paper 3597.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/3597

Department

Biostatistics and Bioinformatics