Under the Hood: The Scientific Leadership, Clinical Operations, Statistical and Data Management, and Laboratory Centers of the Antibacterial Resistance Leadership Group

Authors

Heather R. Cross, Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA.
Kerryl E. Greenwood-Quaintance, Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Maria Souli, Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA.
Lauren Komarow, Biostatistics Center, Department of Biostatistics and Bioinformatics, George Washington University, Rockville, Maryland, USA.
Holly S. Geres, Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA.
Toshimitsu Hamasaki, Biostatistics Center, Department of Biostatistics and Bioinformatics, George Washington University, Rockville, Maryland, USA.
Henry F. Chambers, Division of Infectious Diseases, Department of Medicine, University of California, San Francisco, California, USA.
Vance G. Fowler, Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA.
Scott R. Evans, Biostatistics Center, Department of Biostatistics and Bioinformatics, George Washington University, Rockville, Maryland, USA.
Robin Patel, Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.

Document Type

Journal Article

Publication Date

10-16-2023

Journal

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Volume

77

Issue

Suppl 4

DOI

10.1093/cid/ciad529

Keywords

antibacterial resistance; clinical trial network; infectious disease; laboratory testing; statistics

Abstract

Developing and implementing the scientific agenda of the Antibacterial Resistance Leadership Group (ARLG) by soliciting input and proposals, transforming concepts into clinical trials, conducting those trials, and translating trial data analyses into actionable information for infectious disease clinical practice is the collective role of the Scientific Leadership Center, Clinical Operations Center, Statistical and Data Management Center, and Laboratory Center of the ARLG. These activities include shepherding concept proposal applications through peer review; identifying, qualifying, training, and overseeing clinical trials sites; recommending, developing, performing, and evaluating laboratory assays in support of clinical trials; and designing and performing data collection and statistical analyses. This article describes key components involved in realizing the ARLG scientific agenda through the activities of the ARLG centers.

APA Citation

Cross, Heather R.; Greenwood-Quaintance, Kerryl E.; Souli, Maria; Komarow, Lauren; Geres, Holly S.; Hamasaki, Toshimitsu; Chambers, Henry F.; Fowler, Vance G.; Evans, Scott R.; and Patel, Robin, "Under the Hood: The Scientific Leadership, Clinical Operations, Statistical and Data Management, and Laboratory Centers of the Antibacterial Resistance Leadership Group" (2023). GW Authored Works. Paper 3596.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/3596

Department

Biostatistics and Bioinformatics