Strengthening the Evidence: Similar Rates of Neural Tube Defects Among Deliveries Regardless of Maternal HIV Status and Dolutegravir Exposure in Hospital Birth Surveillance in Eswatini

Document Type

Journal Article

Publication Date

9-1-2023

Journal

Open forum infectious diseases

Volume

10

Issue

9

DOI

10.1093/ofid/ofad441

Keywords

Eswatini; HIV; birth defect; dolutegravir; surveillance

Abstract

Birth defect surveillance in Eswatini in 2020-2021 identified 0.80% defects (197/24 599 live and stillborn infants). Neural tube defect (NTD) prevalence was 0.08%, 0.08%, and 0.15% for 4902 women on dolutegravir preconception, 17 285 HIV-negative women, and 1320 women on efavirenz preconception, respectively, more definitively refuting the dolutegravir preconception NTD safety signal.

Department

Biostatistics and Bioinformatics

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