Strengthening the Evidence: Similar Rates of Neural Tube Defects Among Deliveries Regardless of Maternal HIV Status and Dolutegravir Exposure in Hospital Birth Surveillance in Eswatini
Document Type
Journal Article
Publication Date
9-1-2023
Journal
Open forum infectious diseases
Volume
10
Issue
9
DOI
10.1093/ofid/ofad441
Keywords
Eswatini; HIV; birth defect; dolutegravir; surveillance
Abstract
Birth defect surveillance in Eswatini in 2020-2021 identified 0.80% defects (197/24 599 live and stillborn infants). Neural tube defect (NTD) prevalence was 0.08%, 0.08%, and 0.15% for 4902 women on dolutegravir preconception, 17 285 HIV-negative women, and 1320 women on efavirenz preconception, respectively, more definitively refuting the dolutegravir preconception NTD safety signal.
APA Citation
Gill, Michelle M.; Khumalo, Philisiwe; Chouraya, Caspian; Kunene, Mthokozisi; Dlamini, Futhi; Hoffman, Heather J.; Scheuerle, Angela E.; Nhlabatsi, Bonisile; Mngometulu, Wiseman; Dlamini-Madlopha, Ntombikayise; Mthunzi, Nompumelelo; and Mofenson, Lynne, "Strengthening the Evidence: Similar Rates of Neural Tube Defects Among Deliveries Regardless of Maternal HIV Status and Dolutegravir Exposure in Hospital Birth Surveillance in Eswatini" (2023). GW Authored Works. Paper 3465.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/3465
Department
Biostatistics and Bioinformatics