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Submissions from 2020

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A Unified ILP Framework for Core Ancestral Genome Reconstruction Problems., Pavel Avdeyev, Nikita Alexeev, Yongwu Rong, and Max A. Alekseyev

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An Observational Study of the Equivalence of Age and Duration of Diabetes to Glycemic Control Relative to the Risk of Complications in the Combined Cohorts of the DCCT/EDIC Study., Ionut Bebu, Barbara H. Braffett, David Schade, William Sivitz, John I Malone, Rodica Pop-Busui, Gayle M Lorenzi, Pearl Lee, Victoria R. Trapani, Amisha Wallia, William H Herman, and John M. Lachin

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Risk Factors for First and Subsequent CVD Events in Type 1 Diabetes: The DCCT/EDIC Study., Ionut Bebu, David Schade, Barbara Braffett, Mikhail Kosiborod, Maria Lopes-Virella, Elsayed Z. Soliman, William H. Herman, David A. Bluemke, Amisha Wallia, Trevor Orchard, and John M. Lachin

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Risk Factors for Diabetic Peripheral Neuropathy and Cardiovascular Autonomic Neuropathy in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study., Barbara H. Braffett, Rose A. Gubitosi-Klug, James W. Albers, Eva L. Feldman, Catherine L. Martin, Neil H. White, Trevor J. Orchard, Maria Lopes-Virella, John M. Lachin, Rodica Pop-Busui, and DCCT/EDIC Study Group

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Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities., Karen D Davis, Nima Aghaeepour, Andrew H Ahn, Martin S Angst, David Borsook, Ashley Brenton, Michael E Burczynski, Christopher Crean, Robert Edwards, Brice Gaudilliere, Georgene W Hergenroeder, Michael J Iadarola, Smriti Iyengar, Yunyun Jiang, Jiang-Ti Kong, Sean Mackey, Carl Y Saab, Christine N Sang, Joachim Scholz, Marta Segerdahl, Irene Tracey, Christin Veasley, Jing Wang, Tor D Wager, Ajay D Wasan, and Mary Ann Pelleymounter

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The Adaptive designs CONSORT Extension (ACE) statement: a checklist with explanation and elaboration guideline for reporting randomised trials that use an adaptive design., Munyaradzi Dimairo, Philip Pallmann, James Wason, Susan Todd, Thomas Jaki, Steven A Julious, Adrian P Mander, Christopher J Weir, Franz Koenig, Marc K Walton, Jon P Nicholl, Elizabeth Coates, Katie Biggs, Toshimitsu Hamasaki, Michael A Proschan, John A Scott, Yuki Ando, Daniel Hind, and Douglas G Altman

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Elective Labor Induction at 39 Weeks of Gestation Compared With Expectant Management: Factors Associated With Adverse Outcomes in Low-Risk Nulliparous Women., Yasser Y El-Sayed, Madeline Murguia Rice, William A Grobman, Uma M Reddy, Alan T N Tita, Robert M Silver, Gail Mallett, Kim Hill, Elizabeth A. Thom, Ronald J Wapner, Dwight J Rouse, George R Saade, John M Thorp, Suneet P Chauhan, Edward K Chien, Brian M Casey, Ronald S Gibbs, Sindhu K Srinivas, Geeta K Swamy, Hyagriv N Simhan, and George A Macones

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Methodologies for pragmatic and efficient assessment of benefits and harms: Application to the SOCRATES trial., Scott R. Evans, Mikael Knutsson, Pierre Amarenco, Gregory W Albers, Philip M Bath, Hans Denison, Per Ladenvall, Jenny Jonasson, J Donald Easton, Kazuo Minematsu, Carlos A Molina, Yongjun Wang, Ks Lawrence Wong, and S Claiborne Johnston

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In infants with severe bronchiolitis: dual-transcriptomic profiling of nasopharyngeal microbiome and host response., Michimasa Fujiogi, Carlos A Camargo, James P Bernot, Robert J Freishtat, Brennan Harmon, Jonathan M Mansbach, Eduardo Castro-Nallar, Marcos Perez-Losada, and Kohei Hasegawa

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A cross-sectional study to characterize local HIV-1 dynamics in Washington, DC using next-generation sequencing., Keylie M Gibson, Kamwing Jair, Amanda D Castel, Matthew L Bendall, Brittany Wilbourn, Jeanne A Jordan, Keith A Crandall, and Marcos Pérez-Losada

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Validation of Variant Assembly Using HAPHPIPE with Next-Generation Sequence Data from Viruses., Keylie M. Gibson, Margaret C. Steiner, Uzma Rentia, Matthew L. Bendall, Marcos Pérez-Losada, and Keith A. Crandall

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Active pediatric HIV case finding in Kenya and Uganda: A look at missed opportunities along the prevention of mother-to-child transmission of HIV (PMTCT) cascade., Michelle M Gill, Eliab K Natumanya, Heather J. Hoffman, Gordon Okomo, Geoffrey Taasi, Laura Guay, and Rose Masaba

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Subclinical Hearing Loss is Associated With Depressive Symptoms., Justin S. Golub, Katharine K. Brewster, Adam M. Brickman, Adam J. Ciarleglio, Ana H. Kim, José A. Luchsinger, and Bret R. Rutherford

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Temporal Dynamics of Bacterial Communities in a Pilot-Scale Vermireactor Fed with Distilled Grape Marc., María Gómez-Brandón, Manuel Aira, Natielo Santana, Marcos Pérez-Losada, and Jorge Domínguez

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Longitudinal Associations of the Cystic Fibrosis Airway Microbiome and Volatile Metabolites: A Case Study., Andrea Hahn, Katrine Whiteson, Trenton J Davis, Joann Phan, Iman Sami, Anastassios C Koumbourlis, Robert J Freishtat, Keith A. Crandall, and Heather D Bean

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Refractive Error and Retinopathy Outcomes in Type 1 Diabetes: the DCCT/EDIC Study., Dean P Hainsworth, Xiaoyu Gao, Ionut Bebu, Arup Das, Lisa Olmos de Koo, Andrew J Barkmeier, William Tamborlane, John M. Lachin, and Lloyd Paul Aiello

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Refractive Error and Retinopathy Outcomes in Type 1 Diabetes: The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study., Dean P Hainsworth, Xiaoyu Gao, Ionut Bebu, Arup Das, Lisa Olmos de Koo, Andrew J Barkmeier, William Tamborlane, John M. Lachin, and Lloyd Paul Aiello

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Statistical Challenges in the Conduct and Management of Ongoing Clinical Trials During the COVID-19 Pandemic, Toshimitsu Hamasaki, F Bretz, F Cooner, L M. LaVange, and M Posch

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Development of New Antimicrobials for Urogenital Gonorrhea Therapy: Clinical Trial Design Considerations., Edward W. Hook, Lori Newman, George Drusano, Scott Evans, H Hunter Handsfield, Ann E. Jerse, Fabian Y S Kong, Jeannette Y. Lee, Stephanie N. Taylor, and Carolyn Deal

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Insights Into the Resistome of Bovine Clinical Mastitis Microbiome, a Key Factor in Disease Complication., M Nazmul Hoque, Arif Istiaq, Rebecca A. Clement, Keylie M. Gibson, Otun Saha, Ovinu Kibria Islam, Ruhshan Ahmed Abir, Munawar Sultana, Amam Zonaed Siddiki, Keith A. Crandall, and M Anwar Hossain

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Microbiome dynamics and genomic determinants of bovine mastitis., M Nazmul Hoque, Arif Istiaq, M Shaminur Rahman, M Rafiul Islam, Azraf Anwar, A M A M Zonaed Siddiki, Munawar Sultana, Keith A. Crandall, and M Anwar Hossain

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Prenatal Repair of Myelomeningocele and School-age Functional Outcomes., Amy J. Houtrow, Elizabeth A. Thom, Jack M. Fletcher, Pamela K. Burrows, N Scott Adzick, Nina H. Thomas, John W. Brock 3rd, Timothy Cooper, Hanmin Lee, Larissa Bilaniuk, Orit A. Glenn, Sumit Pruthi, Cora MacPherson, Diana L. Farmer, Mark P. Johnson, Lori J. Howell, Nalin Gupta, and William O. Walker

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Genome-wide analysis of SARS-CoV-2 virus strains circulating worldwide implicates heterogeneity., M Rafiul Islam, M Nazmul Hoque, M Shaminur Rahman, A S M Rubayet Ul Alam, Masuda Akther, J Akter Puspo, Salma Akter, Munawar Sultana, Keith A. Crandall, and M Anwar Hossain

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Ticagrelor and Aspirin or Aspirin Alone in Acute Ischemic Stroke or TIA., S Claiborne Johnston, Pierre Amarenco, Hans Denison, Scott R. Evans, Anders Himmelmann, Stefan James, Mikael Knutsson, Per Ladenvall, Carlos A Molina, and Yongjun Wang

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Infertility, gravidity, and risk of diabetes among high-risk women in the Diabetes Prevention Program Outcomes Study., Catherine Kim, Naji Younes, Marinella Temprosa, Sharon Edelstein, Ronald B. Goldberg, Maria G. Araneta, Amisha Wallia, Angela Brown, Christine Darwin, Uzoma Ibebuogu, Xavier Pi-Sunyer, and William C. Knowler

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Human Endogenous Retrovirus Expression Is Associated with Head and Neck Cancer and Differential Survival., Allison R Kolbe, Matthew L Bendall, Alexander T Pearson, Doru Paul, Douglas F Nixon, Marcos Pérez-Losada, and Keith A. Crandall

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Nonparametric Statistical Analysis, John M. Lachin

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Nonparametric Statistical Analysis., John M. Lachin

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Models to Assess the Association of a Semi-Quantitative Exposure With Outcomes., John M. Lachin, Ionut Bebu, and Barbara Braffett

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Comment on Miller and Orchard: Understanding Metabolic Memory: A Tale of Two Studies. Diabetes 2020;69:291-299., John M. Lachin, David M Nathan, Bernard Zinman, and Ionut Bebu

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The Emperor's New Clothes: PRospective Observational Evaluation of the Association Between Initial VancomycIn Exposure and Failure Rates Among ADult HospitalizEd Patients With Methicillin-resistant Staphylococcus aureus Bloodstream Infections (PROVIDE)., Thomas P. Lodise, Susan L. Rosenkranz, Matthew Finnemeyer, Scott Evans, Matthew Sims, Marcus J. Zervos, C Buddy Creech, Pratish C. Patel, Michael Keefer, Paul Riska, Fernanda P. Silveira, Marc Scheetz, Richard G. Wunderink, Martin Rodriguez, John Schrank, Susan C. Bleasdale, Sara Schultz, Michelle Barron, Ann Stapleton, Dannah Wray, Henry Chambers, Vance G. Fowler, and Thomas L. Holland

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Geographical isolation and restricted gene flow drive speciation of Aegla singularis (Decapoda: Anomura: Aeglidae) in southern South America, G Loretan, E C. Rueda, J M. Cabrera, M. Perez-Losada, P A. Collins, and F Giri

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Prevalence of microvascular and macrovascular disease in the Glycemia Reduction Approaches in Diabetes - A Comparative Effectiveness (GRADE) Study cohort., Kieren J Mather, Ionut Bebu, Chelsea Baker, Robert M Cohen, Jill P Crandall, Cyrus DeSouza, Jennifer B Green, M Sue Kirkman, Heidi Krause-Steinrauf, Mary Larkin, Jeremy Pettus, Elizabeth R Seaquist, Elsayed Z Soliman, Emily B Schroeder, Deborah J Wexler, and Rodica Pop-Busui

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Evaluation of computational methods for human microbiome analysis using simulated data., Matthieu J Miossec, Sandro L Valenzuela, Marcos Pérez-Losada, W Evan Johnson, Keith A. Crandall, and Eduardo Castro-Nallar

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Applying a Risk-benefit Analysis to Outcomes in Tuberculosis Clinical Trials., Sachiko Miyahara, Ritesh Ramchandani, Soyeon Kim, Scott R. Evans, Amita Gupta, Susan Swindells, Richard E Chaisson, and Grace Montepiedra

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Environmental DNA survey captures patterns of fish and invertebrate diversity across a tropical seascape., Bryan N Nguyen, Elaine W Shen, Janina Seemann, Adrienne M S Correa, James L O'Donnell, Andrew H Altieri, Nancy Knowlton, Keith A. Crandall, Scott P Egan, W Owen McMillan, and Matthieu Leray

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Review of otitis media microbiome studies: What do they tell us?, Juan Carlos Nogues, Marcos Pérez-Losada, and Diego Preciado

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Hemiptera phylogenomic resources: tree-based orthology prediction and conserved exon identification., Christopher L. Owen, David B. Stern, Sarah K. Hilton, and Keith A. Crandall

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High-throughput sequencing (HTS) for the analysis of viral populations, Marcos Pérez-Losada, Miguel Arenas, Juan Carlos Galán, M. Alma Bracho, Julia Hillung, Neris García-González, and Fernando González-Candelas

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Testing the "Grandma Hypothesis": Characterizing Skin Microbiome Diversity as a Project-Based Learning Approach to Genomics., Marcos Pérez-Losada, Kelly M. Crandall, and Keith A. Crandall

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Innate IFN-lambda responses to dsRNA in the human infant airway epithelium and clinical regulatory factors during viral respiratory infections in early life., Kyle Salka, Maria Arroyo, Elizabeth Chorvinsky, Karima Abutaleb, Geovanny F Perez, Seth Wolf, Xilei Xuchen, Jered Weinstock, Maria J Gutierrez, Marcos Pérez-Losada, Dinesh K Pillai, and Gustavo Nino

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Innate IFN-lambda responses to dsRNA in the human infant airway epithelium and clinical regulatory factors during viral respiratory infections in early life., Kyle Salka, Maria Arroyo, Elizabeth Chorvinsky, Karima Abutaleb, Geovanny F. Perez, Seth Wolf, Xilei Xuchen, Jered Weinstock, Maria J. Gutierrez, Marcos Pérez-Losada, Dinesh K. Pillai, and Gustavo Nino

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Customized Probability of Vaginal Delivery With Induction of Labor and Expectant Management in Nulliparous Women at 39 Weeks of Gestation., Robert M Silver, Madeline Murguia Rice, William A Grobman, Uma M Reddy, Alan T N Tita, Gail Mallett, Kim Hill, Elizabeth A. Thom, Yasser Y El-Sayed, Ronald J Wapner, Dwight J Rouse, George R Saade, John M Thorp, Suneet P Chauhan, Edward K Chien, Brian M Casey, Ronald S Gibbs, Sindhu K Srinivas, Geeta K Swamy, Hyagriv N Simhan, and George A Macones

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Drug Resistance Prediction Using Deep Learning Techniques on HIV-1 Sequence Data., Margaret C Steiner, Keylie M Gibson, and Keith A. Crandall

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Modern Clinician-initiated Clinical Trials to Determine Optimal Therapy for Multidrug-resistant Gram-negative Infections., Adam G Stewart, Patrick N A Harris, Mark Chatfield, Scott R. Evans, David van Duin, and David L Paterson

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Consumption of Beverages Containing Low-Calorie Sweeteners, Diet, and Cardiometabolic Health in Youth With Type 2 Diabetes., Allison C. Sylvetsky, Avinash Chandran, Sameera A. Talegawkar, Jean A. Welsh, Kimberly Drews, and Laure El Ghormli

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Fetoscopic Tracheal Occlusion for Severe Congenital Diaphragmatic Hernia: The State of the Evidence., Elizabeth A. Thom

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Variants in the Kisspeptin-GnRH Pathway Modulate the Hormonal Profile and Reproductive Outcomes., Camila Martins Trevisan, Michel Satya Naslavsky, Frederico Monfardini, Jaqueline Wang, Mayana Zatz, Carla Peluso, Renata Pellegrino, Fernanda Mafra, Hakon Hakonarson, Frederico Moraes Ferreira, Helder Nakaya, Denise Maria Christofolini, Erik Montagna, Keith A. Crandall, Caio Parente Barbosa, and Bianca Bianco

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Long-term outcomes in Juvenile Myositis patients., Vladislav Tsaltskan, Annette Aldous, Sam Serafi, Anna Yakovleva, Heidi Sami, Gulnara Mamyrova, Ira N. Targoff, Adam Schiffenbauer, Frederick W. Miller, Samuel J. Simmens, Rodolfo Curiel, Olcay Y. Jones, and Lisa G. Rider

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The Cancer Microbiome: Distinguishing Direct and Indirect Effects Requires a Systemic View., Joao B. Xavier, Vincent B. Young, Joseph Skufca, Fiona Ginty, Traci Testerman, Alexander T. Pearson, Paul Macklin, Amir Mitchell, Ilya Shmulevich, Lei Xie, J Gregory Caporaso, Keith A. Crandall, Nicole L. Simone, Filipa Godoy-Vitorino, Timothy J. Griffin, Katrine L. Whiteson, Heather H. Gustafson, Daniel J. Slade, Thomas M. Schmidt, Marina R S Walther-Antonio, Tal Korem, Bobbie-Jo M. Webb-Robertson, Mark P. Styczynski, W Evan Johnson, Christian Jobin, Jason M. Ridlon, Andrew Y. Koh, Michael Yu, Libusha Kelly, and Jennifer A. Wargo

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The effects of environment and ontogeny on the skin microbiome of two Stegastes damselfishes (Pomacentridae) from the eastern Caribbean Sea, R Xavier, A Pereira, A Pagan, G C. Hendrick, M D. Nicholson, D Rosado, M C. Soares, and Marcos Perez-Losada

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Sequential Multiple Assignment Randomized Trials for COMparing Personalized Antibiotic StrategieS (SMART COMPASS): Design Considerations, Xiaoyan Yin, Toshimitsu Hamasaki, and Scott R. Evans

Submissions from 2019

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Urinary angiotensinogen antedates the development of stage 3 CKD in patients with type 1 diabetes mellitus, Sheeba Ba Aqeel, Minghao Ye, Jan Wysocki, Alejandro Sanchez, Ahmed Khattab, Enrique Lores, Alfred Rademaker, Xiaoyu Gao, Ionut Bebu, Robert G. Nelson, Mark Molitch, Daniel Batlle, and Diabetes Control Complications Trual (DCCT)/ Epidemiology of Diabetes Interventions Complications (EDIC) Study

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Interim Monitoring for Futility in Clinical Trials With Two Co-Primary Endpoints Using Prediction, Koko Asakura, Scott R. Evans, and Toshimitsu Hamasaki

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Serum apolipoproteins and apolipoprotein-defined lipoprotein subclasses: a hypothesis-generating prospective study of cardiovascular events in T1D., Arpita Basu, Ionut Bebu, Alicia J Jenkins, Julie A Stoner, Ying Zhang, Richard L Klein, Maria F Lopes-Virella, W Timothy Garvey, Matthew J Budoff, Petar Alaupovic, and Timothy J Lyons

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Telescope: Characterization of the retrotranscriptome by accurate estimation of transposable element expression, Matthew L. Bendall, Miguel de Mulder, Luis Pedro Iniguez, Aaron Lecanda-Sanchez, Marcos Perez-Losada, Mario A. Ostrowski, R. Brad Jones, Lubbertus C. F. Mulder, Gustavo Reyes-Teran, Keith A. Crandall, Christopher E. Ormsby, and Douglas F. Nixon

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2573. Impact of Anaerobic Antibacterial Spectrum on Cystic Fibrosis Lung Microbiome Diversity and Pulmonary Function, Michael Bozzella, Hollis Chaney, Iman Sami, Geovanny Perez, Anastassios Koumbourlis, James Bost, Robert Freishtat, Keith Crandell, and Andrea Hahn

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Rapid bacterial community changes during vermicomposting of grape marc derived from red winemaking, M. G. Brandon, M. Aira, A. R. Kolbe, N. de Andrade, M. Perez-Losada, and J Dominguez

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Frailty and Its Correlates in Adults With Late Life Depression, P J. Brown, S P. Roose, K R. O'Boyle, A Ciarleglio, B Mass, K C. Igwe, S Chung, S Gomez, M Naqvi, A M. Brickman, and B R. Rutherford

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2168. Comparison of Rapid Diagnostic Tests for Bloodstream Infections Using Desirability of Outcome Ranking Management of Antimicrobial Therapy (DOOR-MAT), Kimberly C. Claeys, Teri Hopkins, Zegbeh Kpadeh-Rogers, Yunyun Jiang, Scott R. Evans, J Kristie Johnson, and Surbhi Leekha

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151. Comparing the Clinical Utility of Rapid Diagnostic Tests for Gram-Negative Bloodstream Infection Using a Desirability of Outcomes Ranking, Kimberly C. Claeys, Kathryn Schlaffer, Zegbeh Kpadeh-Rogers, Yunyun Jiang, Scott R. Evans, J Kristie Johnson, and Surbhi Leekha

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Simultaneous Evaluation of Diagnostic Assays for Pharyngeal and Rectal Neisseria gonorrhoeae and Chlamydia trachomatis Using a Master Protocol, S B. Doernberg, L Komarow, T T T. Tran, Z Sund, M W. Pandori, D Jensen, E L. Tsalik, C D. Deal, H F. Chambers, V G. Fowler, S R. Evans, R Patel, J D. Klausner, and Antibacterrial Resistance Leadership Group

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Evaluation of haplotype callers for next-generation sequencing of viruses, Anton Eliseev, Keylie M. Gibson, Pavel Avdeyev, Dmitry Novik, Matthew L. Bendall, Marcos Perez-Losada, Nikita Alexeev, and Keith A. Crandall

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Presenting Risks and Benefits: Helping the Data Monitoring Committee Do Its Job, S R. Evans, R Bigelow, C Chuang-Stein, S S. Ellenberg, P Gallo, W He, Q Jiang, and F Rockhold

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Towards a barnacle tree of life: Integrating diverse phylogenetic efforts into a comprehensive hypothesis of thecostracan evolution, C. Ewers-Saucedo, C. L. Owen, M. Perez-Losada, J. T. Hoeg, H. Glenner, B. K K Chan, and K. A. Crandall

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Analysis of ordered composite endpoints., Dean Follmann, Michael P Fay, Toshimitsu Hamasaki, and Scott Evans

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Improving study conduct and data quality in clinical trials of chronic pain treatments: IMMPACT recommendations., Jennifer S. Gewandter, Robert H. Dworkin, Dennis C. Turk, Eric G. Devine, David Hewitt, Mark P. Jensen, Nathaniel P. Katz, Amy A. Kirkwood, Richard Malamut, John D. Markman, Bernard Vrijens, Laurie Burke, James N. Campbell, Daniel B. Carr, Philip G. Conaghan, Penney Cowan, Mittie K. Doyle, Robert R. Edwards, Scott R. Evans, John T. Farrar, Roy Freeman, Ian Gilron, Dean Juge, Robert D. Kerns, Ernest A. Kopecky, Michael P. McDermott, Gwendolyn Niebler, Kushang V. Patel, Richard Rauck, Andrew S C Rice, Michael Rowbotham, Nelson E. Sessler, Lee S. Simon, Neil Singla, Vladimir Skljarevski, Tina Tockarshewsky, Geertrui F. Vanhove, Ajay D. Wasan, and James Witter

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Corrigendum: A 28-Year History of HIV-1 Drug Resistance and Transmission in Washington, DC, Keylie M. Gibson, Margaret C. Steiner, Seble Kassaye, Frank Maldarelli, Zehava Grossman, Marcos Perez-Losada, and Keith A. Crandall

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Association of Subclinical Hearing Loss With Cognitive Performance, J S. Golub, A M. Brickman, A J. Ciarleglio, N Schupf, and J A. Luchsinger

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SUBCLINICAL AGE-RELATED HEARING LOSS IS INVERSELY ASSOCIATED WITH DEPRESSIVE SYMPTOMS, Justin S. Golub, Katharine K. Brewster, Adam Brickman, Adam Ciarleglio, Jose Luchsinger, and Bret Rutherford

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Screening eye exams in youth with type 1 diabetes under 18 years of age: Once may be enough?, Rose A. Gubitosi-Klug, Ionut Bebu, Neil H. White, John Malone, Ryan Miller, Gayle M. Lorenzi, Dean P. Hainsworth, Victoria R. Trapani, John M. Lachin, and William V. Tamborlane

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Mutated CEACAMs Disrupt Transforming Growth Factor beta Signaling and Alter the Intestinal Microbiome to Promote Colorectal Carcinogenesis, Shoujun Gu, Sobia Zaidi, Md Imtaiyaz Hassan, Taj Mohammad, Tathiane M. Malta, Houtan Noushmehr, Bryan Nguyen, Keith A. Crandall, Jigisha Srivastav, Vincent Obias, Paul Lin, Bao-Ngoc Nguyen, Michael Yao, Ren Yao, Charles Hadley King, Raja Mazumder, Bibhuti Mishra, Shuyun Rao, and Lopa Mishra

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Metagenomic deep sequencing reveals association of microbiome signature with functional biases in bovine mastitis., M Nazmul Hoque, Arif Istiaq, Rebecca A. Clement, Munawar Sultana, Keith A. Crandall, Amam Zonaed Siddiki, and M Anwar Hossain

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Fecal Transplant in Children With Clostridioides difficile Gives Sustained Reduction in Antimicrobial Resistance and Potential Pathogen Burden, Suchitra K. Hourigan, Michelle Ahn, Keylie M. Gibson, Marcos Perez-Losada, Grace Felix, Melissa Weidner, Ian Leibowitz, John E. Niederhuber, Cynthia L. Sears, Keith A. Crandall, and Maria Oliva-Hemker

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Diet quality and hearing loss among middle-older aged adults in the USA: findings from National Health and Nutrition Examination Survey, Q Huang, Y Jin, N S. Reed, Y Ma, M C. Power, and S A. Talegawkar

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Transcriptomic analysis of human endogenous retroviruses in systemic lupus erythematosus, Luis P. Iniguez, Miguel de Mulder Rougvie, Nathaniel Stearrett, Richard B. Jones, Christopher E. Ormsby, Gustavo Reyes-Teran, Keith A. Crandell, Douglas F. Nixon, and Matthew L. Bendall

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Evaluation of the longitudinal change in health behavior profiles across treatment groups in the TODAY clinical trial., Jill L. Kaar, Sarah J. Schmiege, Kimberly Drews, Janine Higgins, Natalie Walders-Abramson, Elvira Isganaitis, Steven M. Willi, Marsha D. Marcus, Philip S. Zeitler, and Megan M. Kelsey

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Altered Middle Ear Microbiome in Children With Chronic Otitis Media With Effusion and Respiratory Illnesses, Allison R. Kolbe, Eduardo Castro-Nallar, Diego Preciado, and Marcos E. Perez-Losada

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Closed testing of each group versus the others combined in a multiple group analysis, J. M. Lachin and I Bebu

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Rationale and Design for a GRADE Substudy of Continuous Glucose Monitoring., Mary E. Larkin, David M. Nathan, Ionut Bebu, Heidi Krause-Steinrauf, William H. Herman, John M. Higgins, Margaret Tiktin, Robert M. Cohen, Claire Lund, Richard M. Bergenstal, Mary L. Johnson, and Valerie Arends

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The Kronos Early Estrogen Prevention Study (KEEPS): what have we learned?, Virginia M Miller, Fredrick Naftolin, Sanjay Asthana, Dennis M. Black, Eliot A. Brinton, Matthew J. Budoff, Marcelle I. Cedars, N Maritza Dowling, Carey E. Gleason, Howard N. Hodis, Muthuvel Jayachandran, Kejal Kantarci, Rogerio A. Lobo, JoAnn E. Manson, Lubna Pal, Nanette F. Santoro, Hugh S. Taylor, and S Mitchell Harman

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Applying Risk-Benefit Analysis to Outcomes in TB Clinical Trials., Sachiko Miyahara, Ritesh Ramchandani, Soyeon Kim, Scott R. Evans, Amita Gupta, Susan Swindells, Richard E. Chaisson, and Grace Montepiedra

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Does diabetes prevention translate into reduced long-term vascular complications of diabetes?, David M. Nathan, Peter H. Bennett, Jill P. Crandall, Sharon L. Edelstein, Ronald B. Goldberg, Steven E. Kahn, William C. Knowler, Kieren J. Mather, Sunder Mudaliar, Trevor J. Orchard, Marinella Temprosa, and Neil H. White

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Myelomeningocele sac associated with worse lower extremity neurologic sequela: evidence for prenatal neural stretch injury?, E R. Oliver, G G. Heuer, E A. Thom, P K. Burrows, R A. Didier, S E. DeBari, J S. Martin-Saavedra, J S. Moldenhauer, J Jatres, L J. Howell, N S. Adzick, and B G. Coleman

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Optimising treatment decision rules through generated effect modifiers: a precision medicine tutorial, Eva Petkova, Hyung Park, Adam Ciarleglio, R. Todd Ogden, and Thaddeus Tarpey

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Recombinant Opisthorchis viverrini tetraspanin expressed in Pichia pastoris as a potential vaccine candidate for opisthorchiasis, L T. Phung, S Chaiyadet, N Hongsrichan, J Sotillo, H D T Dieu, C Q. Tran, P J. Brindley, A Loukas, and T Laha

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Diabetes Care Editors' Expert Forum 2018: Managing Big Data for Diabetes Research and Care, M C. Riddle, L Blonde, H C. Gerstein, E W. Gregg, R R. Holman, J M. Lachin, G A. Nichols, A Turchin, and W T. Cefalu

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Effects of disease, antibiotic treatment and recovery trajectory on the microbiome of farmed seabass (Dicentrarchus labrax)., Daniela Rosado, Raquel Xavier, Ricardo Severino, Fernando Tavares, Jo Cable, and Marcos Pérez-Losada

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Cancer Incidence and Mortality in Firefighters: A State-of-the-Art Review and Meta-َAnalysis, E. S. Soteriades, J. Kim, C. A. Christophi, and S. N. Kales

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ReQTL: Identifying correlations between expressed SNVs and gene expression using RNA-sequencing data, Liam Spurr, Nawaf Alomran, Pavlos Bousounis, Dacian Reece-Stremtan, NM Prashant, Honguy Liu, Piotr Slowinski, Muzi Li, Qianqian Zhang, Justin Sein, Gabriel Asher, Keith A. Crandall, Krasimira Tsaneva-Atanasova, and Anelia Horvath

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Modern clinician-initiated clinical trials to determine optimal therapy for multi-drug resistant Gram-negative infections, A G. Stewart, P N A Harris, M Chatfield, S R. Evans, D van Duin, and D L. Paterson

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2276. Clinical Epidemiology of the Carbapenem-Resistant Enterobacteriaceae (CRE) Epidemic in Colombia: A Multicenter Prospective Study, Sandra Liliana Valderrama-Beltran, Lauren Komarow, Soraya Salcedo, Laura Mora, Adriana Marin, Karen M. Ordonez Diaz, Edilberto Cristancho Quintero, Beatriz Elena Ariza, Gloria Cortes, De la Hoz Alejandro, Jose Onate, Elsa Yasmin Vente, Viviana Mendez, Jairo Figueroa, Luz Osorio, Carlos Moreno, Jinnethe Reyes, Luis Dulcey, Pallares Christian, Henry Chambers, Vance G. Fowler, Scott R. Evans, Barry Kreiswirth, Maria Virginia Villegas, Robert A. Bonomo, David van Duin, and Cesar A. Arias

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Randomization tests for multiarmed randomized clinical trials., Yanying Wang, William F. Rosenberger, and Diane Uschner

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Acinetobacter infections, B. M. Wilson, F. Perez, Q. Pan, Y. Jiang, S. Evans, and R. A. Bonomo

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The Consortium of Metabolomics Studies (COMETS): Metabolomics in 47 Prospective Cohort Studies., Bing Yu, Krista A. Zanetti, Marinella Temprosa, Demetrius Albanes, Nathan Appel, Clara Barrios Barrera, Yoav Ben-Shlomo, Eric Boerwinkle, Juan P. Casas, Clary Clish, Caroline Dale, Abbas Dehghan, Andriy Derkach, A Heather Eliassen, Paul Elliott, Eoin Fahy, Christian Gieger, Marc J. Gunter, Sei Harada, Tamara Harris, Deron R. Herr, David Herrington, Joel N. Hirschhorn, Elise Hoover, Ann W. Hsing, Mattias Johansson, Rachel S. Kelly, Chin Meng Khoo, Mika Kivimäki, Bruce S. Kristal, Claudia Langenberg, Jessica Lasky-Su, Deborah A. Lawlor, Luca A. Lotta, Massimo Mangino, Loïc Le Marchand, Ewy Mathé, Charles E. Matthews, Cristina Menni, Lorelei A. Mucci, Rachel Murphy, Matej Oresic, Eric Orwoll, Jennifer Ose, Alexandre C. Pereira, Mary C. Playdon, Lucilla Poston, Jackie Price, Qibin Qi, Kathryn Rexrode, Adam Risch, Joshua Sampson, Wei Jie Seow, Howard D. Sesso, Svati H. Shah, Xiao-Ou Shu, Gordon C S Smith, Ulla Sovio, Victoria L. Stevens, Rachael Stolzenberg-Solomon, Toru Takebayashi, Therese Tillin, Ruth Travis, Ioanna Tzoulaki, Cornelia M. Ulrich, Ramachandran S. Vasan, Mukesh Verma, Ying Wang, Nick J. Wareham, Andrew Wong, Naji Younes, Hua Zhao, Wei Zheng, and Steven C. Moore

Submissions from 2018

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Properties of composite time to first event versus joint marginal analyses of multiple outcomes, Ionut Bebu and John M. Lachin

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Long-Term Benefit of Empagliflozin on Life Expectancy in Patients With Type 2 Diabetes Mellitus and Established Cardiovascular Disease., Brian Claggett, John M. Lachin, Stefan Hantel, David Fitchett, Silvio E. Inzucchi, Hans J. Woerle, Jyothis T. George, and Bernard Zinman

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Multigene phylogeny reveals two new isolated and relic earthworm genera (Oligochaeta: Lumbricidae), Jorge Dominguez, Manuel Aira, Pablo G. Porto, Dario J. Diaz Cosin, and Marcos Perez-Losada

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Comparing neurodevelopmental outcomes at 30 months by presence of hydrocephalus and shunt status among children enrolled in the MOMS trial, A J. Houtrow, P K. Burrows, and E A. Thom

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Identification of Burkholderia fungorum in the urine of an individual with spinal cord injury and augmentation cystoplasty using 16S sequencing: copathogen or innocent bystander?, Emma Nally, Suzanne L. Groah, Marcos Perez-Losada, Ljubica Caldovic, Inger Ljungberg, Neel J. Chandel, Bruce Sprague, Michael H. Hsieh, and Hans G. Pohl