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Submissions from 2021

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Each patient is a research biorepository: informatics-enabled research on surplus clinical specimens via the living BioBank., Alexander V Alekseyenko, Bashir Hamidi, Trevor D Faith, Keith A. Crandall, Jennifer G Powers, Christopher L Metts, James E Madory, Steven L Carroll, Jihad S Obeid, and Leslie A Lenert

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Predictors of 30-Day Unplanned Readmission After Carotid Artery Stenting Using Artificial Intelligence., Amod Amritphale, Ranojoy Chatterjee, Suvo Chatterjee, Nupur Amritphale, Ali Rahnavard, G Mustafa Awan, Bassam Omar, and Gregg C Fonarow

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Predictors of 30-Day Unplanned Readmission After Carotid Artery Stenting Using Artificial Intelligence., Amod Amritphale, Ranojoy Chatterjee, Suvo Chatterjee, Nupur Amritphale, Ali Rahnavard, G Mustafa Awan, Bassam Omar, and Gregg C Fonarow

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Moderation of the effect of glycemia on the risk of cardiovascular disease in type 1 diabetes: The DCCT/EDIC study., Ionut Bebu, Barbara H. Braffett, Trevor J Orchard, Gayle M Lorenzi, David M Nathan, William H Herman, and John M. Lachin

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Development of novel measures for Alzheimer's disease prevention trials (NoMAD)., Sophie A Bell, Hannah R Cohen, Seonjoo Lee, Hyun Kim, Adam Ciarleglio, Howard Andrews, Andres M Rivera, Kay Igwe, Adam M Brickman, D P Devanand, Philip D Harvey, Lon S Schneider, and Terry E Goldberg

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HAPHPIPE: Haplotype Reconstruction and Phylodynamics for Deep Sequencing of Intrahost Viral Populations., Matthew L. Bendall, Keylie M. Gibson, Margaret C. Steiner, Uzma Rentia, Marcos Pérez-Losada, and Keith A. Crandall

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A synthesis tree of the Copepoda: Integrating phylogenetic and taxonomic data reveals multiple origins of parasitism, James P. Bernot, G A. Boxshall, and Keith A. Crandall

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Long-Term Complications in Youth-Onset Type 2 Diabetes., Petter Bjornstad, Kimberly L. Drews, Sonia Caprio, Rose Gubitosi-Klug, David M Nathan, Bereket Tesfaldet, Jeanie Tryggestad, Neil H White, and Philip Zeitler

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Determinants of lower-extremity injury severity and recovery in U.S. High School Soccer Players., Avinash Chandran, Angelo Elmi, Heather Young, and Loretta DiPietro

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Educational Value of Endoscopic Versus Microscopic Ear Surgery., Alexander Chern, Rahul K Sharma, Sarah E Maurrasse, Madeleine A Drusin, Adam J. Ciarleglio, and Justin S Golub

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Study of emotional distress in a comparative effectiveness trial of diabetes treatments: Rationale and design., Andrea L Cherrington, Heidi Krause-Steinrauf, Ionut Bebu, Aanand D Naik, Elizabeth Walker, Sherita H Golden, and Jeffrey S Gonzalez

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Comparing the Clinical Utility of Rapid Diagnostics for Treatment of Bloodstream Infections Using Desirability of Outcome Ranking Approach for the Management of Antibiotic Therapy (DOOR-MAT)., Kimberly C Claeys, Teri L Hopkins, Kathryn Schlaffer, Stephanie Hitchcock, Yunyun Jiang, Scott Evans, J Kristie Johnson, and Surbhi Leekha

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Identification of CRF89_BF, a new member of an HIV-1 circulating BF intersubtype recombinant form family widely spread in South America., Elena Delgado, Aurora Fernández-García, Marcos Pérez-Losada, María Moreno-Lorenzo, Ismael Fernández-Miranda, Sonia Benito, Vanessa Montero, Horacio Gil, Silvia Hernáez, Josefa Muñoz, Miren Z Zubero-Sulibarria, Elena García-Bodas, Mónica Sánchez, Jorge Del Romero, Carmen Rodríguez, Luis Elorduy, Elena Bereciartua, Esther Culebras, Icíar Rodríguez-Avial, María Luisa Giménez-Alarcón, Carmen Martín-Salas, Carmen Gómez-González, José J García-Irure, Gema Cenzual, Ana Martínez-Sapiña, María Maiques-Camarero, Lucía Pérez-Álvarez, and Michael M Thomson

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Inflammation in children with cystic fibrosis: contribution of bacterial production of long-chain fatty acids., Erin Felton, Aszia Burrell, Hollis Chaney, Iman Sami, Anastassios C. Koumbourlis, Robert J. Freishtat, Keith A. Crandall, and Andrea Hahn

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Composite outcomes for pain clinical trials: considerations for design and interpretation., Jennifer S Gewandter, Michael P McDermott, Scott Evans, Nathaniel P Katz, John D Markman, Lee S Simon, Dennis C Turk, and Robert H Dworkin

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More robust estimation of average treatment effects using kernel optimal matching in an observational study of spine surgical interventions., Nathan Kallus, Brenton Pennicooke, and Michele Santacatterina

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A simple framework to identify optimal cost-effective risk thresholds for a single screen: Comparison to Decision Curve Analysis, Hormuzd A. Katki and Ionut Bebu

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Evaluating the effect of a community score card among pregnant and breastfeeding women living with HIV in two districts in Malawi., Megan Kays, Godfrey Woelk, Tegan Callahan, Leila Katirayi, Michele Montandon, Felluna Chauwa, Anne Laterra, Veena Sampathkumar, Dumbani Kayira, Thokozani Kalua, Erin Kazemi, Heather Hoffman, and Surbhi Modi

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Facing Our Fears: The Impact of a 4-Day Training Intervention to Reduce Negative Perspectives on Sexual and Gender Minorities among Religious Leaders in Kenya., David Kuria Mbote, Esther Mombo, Zablon Bundi Mutongu, Anthony Mkutu, Adam Ciarleglio, and Theo G M Sandfort

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Sex Differences in Management and Outcomes of Cardioembolic Stroke: Post HOC Analyses of the RELAXED Study., Takashi Okada, Kazutaka Uchida, Fumihiro Sakakibara, Hiroto Kageyama, Masahiro Yasaka, Kazunori Toyoda, Etsuro Mori, Teruyuki Hirano, Toshimitsu Hamasaki, Hiroshi Yamagami, Takehiko Nagao, Shinichiro Uchiyama, Kazuo Minematsu, and Shinichi Yoshimura

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The effect of patient age on discharge destination and complications after lumbar spinal fusion., Brenton Pennicooke, Michele Santacatterina, Jennifer Lee, Eric Elowitz, and Nathan Kallus

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Felsenstein Phylogenetic Likelihood, David Posada and Keith A. Crandall

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Reply to Villar et al., Michael Proschan and Scott Evans

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Association of Baseline Characteristics With Insulin Sensitivity and β-Cell Function in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness (GRADE) Study Cohort., Neda Rasouli, Naji Younes, Kristina M Utzschneider, Silvio E Inzucchi, Ashok Balasubramanyam, Andrea L Cherrington, Faramarz Ismail-Beigi, Robert M Cohen, Darin E Olson, Ralph A DeFronzo, William H Herman, John M. Lachin, and Steven E Kahn

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Attenuated early pregnancy weight gain by prenatal lifestyle interventions does not prevent gestational diabetes in the LIFE-Moms consortium., Leanne M Redman, Kimberly L. Drews, Samuel Klein, Linda Van Horn, Rena R Wing, Xavier Pi-Sunyer, Mary Evans, Kaumudi Joshipura, S Sonia Arteaga, Alison G Cahill, Rebecca G Clifton, Kimberly A Couch, Paul W Franks, Dympna Gallagher, Debra Haire-Joshu, Corby K Martin, Alan M Peaceman, Suzanne Phelan, Elizabeth A. Thom, Susan Z Yanovski, and William C Knowler

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Effects of aging on the skin and gill microbiota of farmed seabass and seabream., Daniela Rosado, Marcos Pérez-Losada, Ana Pereira, Ricardo Severino, and Raquel Xavier

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Cost-efficient clinical studies with continuous time survival outcomes., Grecio J. Sandoval, Ionut Bebu, and John M. Lachin

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Comparative analysis of the bronchoalveolar microbiome in Portuguese patients with different chronic lung disorders., Susana Seixas, Allison R. Kolbe, Sílvia Gomes, Maria Sucena, Catarina Sousa, Luís Vaz Rodrigues, Gilberto Teixeira, Paula Pinto, Tiago Tavares de Abreu, Cristina Bárbara, Júlio Semedo, Leonor Mota, Ana Sofia Carvalho, Rune Matthiesen, Patrícia Isabel Marques, and Marcos Pérez-Losada

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A Pseudo-Likelihood Approach to Linear Regression With Partially Shuffled Data, Martin Slawski, Guoqing Diao, and Emanuel Ben-David

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Expression of Human Endogenous Retroviruses in Systemic Lupus Erythematosus: Multiomic Integration With Gene Expression., Nathaniel Stearrett, Tyson Dawson, Ali Rahnavard, Prathyusha Bachali, Matthew L Bendall, Chen Zeng, Roberto Caricchio, Marcos Pérez-Losada, Amrie C Grammer, Peter E Lipsky, and Keith A. Crandall

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The Missing Link(age): Multilevel Contributors to Service Uptake Failure Among Youths on Community Justice Supervision., Gail A Wasserman, Larkin S McReynolds, Faye S Taxman, Steven Belenko, Katherine S Elkington, Angela A Robertson, Michael L Dennis, Danica K Knight, Hannah K Knudsen, Richard Dembo, Adam Ciarleglio, and Tisha R A Wiley

Submissions from 2020

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Ticagrelor Added to Aspirin in Acute Ischemic Stroke or Transient Ischemic Attack in Prevention of Disabling Stroke: A Randomized Clinical Trial., Pierre Amarenco, Hans Denison, Scott R. Evans, Anders Himmelmann, Stefan James, Mikael Knutsson, Per Ladenvall, Carlos A Molina, Yongjun Wang, and S Claiborne Johnston

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A Unified ILP Framework for Core Ancestral Genome Reconstruction Problems., Pavel Avdeyev, Nikita Alexeev, Yongwu Rong, and Max A. Alekseyev

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An Observational Study of the Equivalence of Age and Duration of Diabetes to Glycemic Control Relative to the Risk of Complications in the Combined Cohorts of the DCCT/EDIC Study., Ionut Bebu, Barbara H. Braffett, David Schade, William Sivitz, John I Malone, Rodica Pop-Busui, Gayle M Lorenzi, Pearl Lee, Victoria R. Trapani, Amisha Wallia, William H Herman, and John M. Lachin

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Risk Factors for First and Subsequent CVD Events in Type 1 Diabetes: The DCCT/EDIC Study., Ionut Bebu, David Schade, Barbara Braffett, Mikhail Kosiborod, Maria Lopes-Virella, Elsayed Z. Soliman, William H. Herman, David A. Bluemke, Amisha Wallia, Trevor Orchard, and John M. Lachin

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HAPHPIPE: Haplotype Reconstruction and Phylodynamics for Deep Sequencing of Intra-Host Viral Populations., Matthew L. Bendall, Keylie M. Gibson, Margaret C. Steiner, Uzma Rentia, Marcos Pérez-Losada, and Keith A. Crandall

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Risk Factors for Diabetic Peripheral Neuropathy and Cardiovascular Autonomic Neuropathy in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study., Barbara H. Braffett, Rose A. Gubitosi-Klug, James W. Albers, Eva L. Feldman, Catherine L. Martin, Neil H. White, Trevor J. Orchard, Maria Lopes-Virella, John M. Lachin, Rodica Pop-Busui, and DCCT/EDIC Study Group

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Frailty Worsens Antidepressant Treatment Outcomes in Late Life Depression., Patrick J Brown, Adam Ciarleglio, Steven P Roose, Carolina Montes Garcia, Sarah Chung, Johana Alvarez, Alexandra Stein, Stephanie Gomez, and Bret R Rutherford

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Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities., Karen D Davis, Nima Aghaeepour, Andrew H Ahn, Martin S Angst, David Borsook, Ashley Brenton, Michael E Burczynski, Christopher Crean, Robert Edwards, Brice Gaudilliere, Georgene W Hergenroeder, Michael J Iadarola, Smriti Iyengar, Yunyun Jiang, Jiang-Ti Kong, Sean Mackey, Carl Y Saab, Christine N Sang, Joachim Scholz, Marta Segerdahl, Irene Tracey, Christin Veasley, Jing Wang, Tor D Wager, Ajay D Wasan, and Mary Ann Pelleymounter

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Efficient Multiple Imputation for Sensitivity Analysis of Recurrent Events Data With Informative Censoring, Guoqing Diao, G F. Liu, D Zeng, Y Zhang, G Golm, J F. Heyse, and J G. Ibrahim

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The Adaptive designs CONSORT Extension (ACE) statement: a checklist with explanation and elaboration guideline for reporting randomised trials that use an adaptive design., Munyaradzi Dimairo, Philip Pallmann, James Wason, Susan Todd, Thomas Jaki, Steven A Julious, Adrian P Mander, Christopher J Weir, Franz Koenig, Marc K Walton, Jon P Nicholl, Elizabeth Coates, Katie Biggs, Toshimitsu Hamasaki, Michael A Proschan, John A Scott, Yuki Ando, Daniel Hind, and Douglas G Altman

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Elective Labor Induction at 39 Weeks of Gestation Compared With Expectant Management: Factors Associated With Adverse Outcomes in Low-Risk Nulliparous Women., Yasser Y El-Sayed, Madeline Murguia Rice, William A Grobman, Uma M Reddy, Alan T N Tita, Robert M Silver, Gail Mallett, Kim Hill, Elizabeth A. Thom, Ronald J Wapner, Dwight J Rouse, George R Saade, John M Thorp, Suneet P Chauhan, Edward K Chien, Brian M Casey, Ronald S Gibbs, Sindhu K Srinivas, Geeta K Swamy, Hyagriv N Simhan, and George A Macones

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Methodologies for pragmatic and efficient assessment of benefits and harms: Application to the SOCRATES trial., Scott R. Evans, Mikael Knutsson, Pierre Amarenco, Gregory W Albers, Philip M Bath, Hans Denison, Per Ladenvall, Jenny Jonasson, J Donald Easton, Kazuo Minematsu, Carlos A Molina, Yongjun Wang, Ks Lawrence Wong, and S Claiborne Johnston

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In infants with severe bronchiolitis: dual-transcriptomic profiling of nasopharyngeal microbiome and host response., Michimasa Fujiogi, Carlos A Camargo, James P Bernot, Robert J Freishtat, Brennan Harmon, Jonathan M Mansbach, Eduardo Castro-Nallar, Marcos Perez-Losada, and Kohei Hasegawa

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A cross-sectional study to characterize local HIV-1 dynamics in Washington, DC using next-generation sequencing., Keylie M Gibson, Kamwing Jair, Amanda D Castel, Matthew L Bendall, Brittany Wilbourn, Jeanne A Jordan, Keith A Crandall, and Marcos Pérez-Losada

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Validation of Variant Assembly Using HAPHPIPE with Next-Generation Sequence Data from Viruses., Keylie M. Gibson, Margaret C. Steiner, Uzma Rentia, Matthew L. Bendall, Marcos Pérez-Losada, and Keith A. Crandall

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Active pediatric HIV case finding in Kenya and Uganda: A look at missed opportunities along the prevention of mother-to-child transmission of HIV (PMTCT) cascade., Michelle M Gill, Eliab K Natumanya, Heather J. Hoffman, Gordon Okomo, Geoffrey Taasi, Laura Guay, and Rose Masaba

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Subclinical Hearing Loss is Associated With Depressive Symptoms., Justin S. Golub, Katharine K. Brewster, Adam M. Brickman, Adam J. Ciarleglio, Ana H. Kim, José A. Luchsinger, and Bret R. Rutherford

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Temporal Dynamics of Bacterial Communities in a Pilot-Scale Vermireactor Fed with Distilled Grape Marc., María Gómez-Brandón, Manuel Aira, Natielo Santana, Marcos Pérez-Losada, and Jorge Domínguez

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Longitudinal Associations of the Cystic Fibrosis Airway Microbiome and Volatile Metabolites: A Case Study., Andrea Hahn, Katrine Whiteson, Trenton J Davis, Joann Phan, Iman Sami, Anastassios C Koumbourlis, Robert J Freishtat, Keith A. Crandall, and Heather D Bean

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Refractive Error and Retinopathy Outcomes in Type 1 Diabetes: the DCCT/EDIC Study., Dean P Hainsworth, Xiaoyu Gao, Ionut Bebu, Arup Das, Lisa Olmos de Koo, Andrew J Barkmeier, William Tamborlane, John M. Lachin, and Lloyd Paul Aiello

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Refractive Error and Retinopathy Outcomes in Type 1 Diabetes: The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study., Dean P Hainsworth, Xiaoyu Gao, Ionut Bebu, Arup Das, Lisa Olmos de Koo, Andrew J Barkmeier, William Tamborlane, John M. Lachin, and Lloyd Paul Aiello

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Statistical Challenges in the Conduct and Management of Ongoing Clinical Trials During the COVID-19 Pandemic, Toshimitsu Hamasaki, F Bretz, F Cooner, L M. LaVange, and M Posch

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Development of New Antimicrobials for Urogenital Gonorrhea Therapy: Clinical Trial Design Considerations., Edward W. Hook, Lori Newman, George Drusano, Scott Evans, H Hunter Handsfield, Ann E. Jerse, Fabian Y S Kong, Jeannette Y. Lee, Stephanie N. Taylor, and Carolyn Deal

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Insights Into the Resistome of Bovine Clinical Mastitis Microbiome, a Key Factor in Disease Complication., M Nazmul Hoque, Arif Istiaq, Rebecca A. Clement, Keylie M. Gibson, Otun Saha, Ovinu Kibria Islam, Ruhshan Ahmed Abir, Munawar Sultana, Amam Zonaed Siddiki, Keith A. Crandall, and M Anwar Hossain

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Microbiome dynamics and genomic determinants of bovine mastitis., M Nazmul Hoque, Arif Istiaq, M Shaminur Rahman, M Rafiul Islam, Azraf Anwar, A M A M Zonaed Siddiki, Munawar Sultana, Keith A. Crandall, and M Anwar Hossain

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Prenatal Repair of Myelomeningocele and School-age Functional Outcomes., Amy J. Houtrow, Elizabeth A. Thom, Jack M. Fletcher, Pamela K. Burrows, N Scott Adzick, Nina H. Thomas, John W. Brock 3rd, Timothy Cooper, Hanmin Lee, Larissa Bilaniuk, Orit A. Glenn, Sumit Pruthi, Cora MacPherson, Diana L. Farmer, Mark P. Johnson, Lori J. Howell, Nalin Gupta, and William O. Walker

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Genome-wide analysis of SARS-CoV-2 virus strains circulating worldwide implicates heterogeneity., M Rafiul Islam, M Nazmul Hoque, M Shaminur Rahman, A S M Rubayet Ul Alam, Masuda Akther, J Akter Puspo, Salma Akter, Munawar Sultana, Keith A. Crandall, and M Anwar Hossain

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Ticagrelor and Aspirin or Aspirin Alone in Acute Ischemic Stroke or TIA., S Claiborne Johnston, Pierre Amarenco, Hans Denison, Scott R. Evans, Anders Himmelmann, Stefan James, Mikael Knutsson, Per Ladenvall, Carlos A Molina, and Yongjun Wang

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Infertility, gravidity, and risk of diabetes among high-risk women in the Diabetes Prevention Program Outcomes Study., Catherine Kim, Naji Younes, Marinella Temprosa, Sharon Edelstein, Ronald B. Goldberg, Maria G. Araneta, Amisha Wallia, Angela Brown, Christine Darwin, Uzoma Ibebuogu, Xavier Pi-Sunyer, and William C. Knowler

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Human Endogenous Retrovirus Expression Is Associated with Head and Neck Cancer and Differential Survival., Allison R Kolbe, Matthew L Bendall, Alexander T Pearson, Doru Paul, Douglas F Nixon, Marcos Pérez-Losada, and Keith A. Crandall

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Nonparametric Statistical Analysis, John M. Lachin

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Nonparametric Statistical Analysis., John M. Lachin

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Models to Assess the Association of a Semi-Quantitative Exposure With Outcomes., John M. Lachin, Ionut Bebu, and Barbara Braffett

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Comment on Miller and Orchard: Understanding Metabolic Memory: A Tale of Two Studies. Diabetes 2020;69:291-299., John M. Lachin, David M Nathan, Bernard Zinman, and Ionut Bebu

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The Emperor's New Clothes: PRospective Observational Evaluation of the Association Between Initial VancomycIn Exposure and Failure Rates Among ADult HospitalizEd Patients With Methicillin-resistant Staphylococcus aureus Bloodstream Infections (PROVIDE)., Thomas P. Lodise, Susan L. Rosenkranz, Matthew Finnemeyer, Scott Evans, Matthew Sims, Marcus J. Zervos, C Buddy Creech, Pratish C. Patel, Michael Keefer, Paul Riska, Fernanda P. Silveira, Marc Scheetz, Richard G. Wunderink, Martin Rodriguez, John Schrank, Susan C. Bleasdale, Sara Schultz, Michelle Barron, Ann Stapleton, Dannah Wray, Henry Chambers, Vance G. Fowler, and Thomas L. Holland

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Geographical isolation and restricted gene flow drive speciation of Aegla singularis (Decapoda: Anomura: Aeglidae) in southern South America, G Loretan, E C. Rueda, J M. Cabrera, M. Perez-Losada, P A. Collins, and F Giri

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Prevalence of microvascular and macrovascular disease in the Glycemia Reduction Approaches in Diabetes - A Comparative Effectiveness (GRADE) Study cohort., Kieren J Mather, Ionut Bebu, Chelsea Baker, Robert M Cohen, Jill P Crandall, Cyrus DeSouza, Jennifer B Green, M Sue Kirkman, Heidi Krause-Steinrauf, Mary Larkin, Jeremy Pettus, Elizabeth R Seaquist, Elsayed Z Soliman, Emily B Schroeder, Deborah J Wexler, and Rodica Pop-Busui

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Evaluation of computational methods for human microbiome analysis using simulated data., Matthieu J Miossec, Sandro L Valenzuela, Marcos Pérez-Losada, W Evan Johnson, Keith A. Crandall, and Eduardo Castro-Nallar

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Per- and polyfluoroalkyl substance plasma concentrations and metabolomic markers of type 2 diabetes in the Diabetes Prevention Program trial., Susanna D Mitro, Jinxi Liu, Lindsay M Jaacks, Abby F Fleisch, Paige L Williams, William C Knowler, Blandine Laferrère, Wei Perng, George A Bray, Amisha Wallia, Marie-France Hivert, Emily Oken, Tamarra M James-Todd, and Marinella Temprosa

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Applying a Risk-benefit Analysis to Outcomes in Tuberculosis Clinical Trials., Sachiko Miyahara, Ritesh Ramchandani, Soyeon Kim, Scott R. Evans, Amita Gupta, Susan Swindells, Richard E Chaisson, and Grace Montepiedra

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Environmental DNA survey captures patterns of fish and invertebrate diversity across a tropical seascape., Bryan N Nguyen, Elaine W Shen, Janina Seemann, Adrienne M S Correa, James L O'Donnell, Andrew H Altieri, Nancy Knowlton, Keith A. Crandall, Scott P Egan, W Owen McMillan, and Matthieu Leray

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Review of otitis media microbiome studies: What do they tell us?, Juan Carlos Nogues, Marcos Pérez-Losada, and Diego Preciado

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Hemiptera phylogenomic resources: tree-based orthology prediction and conserved exon identification., Christopher L. Owen, David B. Stern, Sarah K. Hilton, and Keith A. Crandall

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High-throughput sequencing (HTS) for the analysis of viral populations, Marcos Pérez-Losada, Miguel Arenas, Juan Carlos Galán, M. Alma Bracho, Julia Hillung, Neris García-González, and Fernando González-Candelas

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Testing the "Grandma Hypothesis": Characterizing Skin Microbiome Diversity as a Project-Based Learning Approach to Genomics., Marcos Pérez-Losada, Kelly M. Crandall, and Keith A. Crandall

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Innate IFN-lambda responses to dsRNA in the human infant airway epithelium and clinical regulatory factors during viral respiratory infections in early life., Kyle Salka, Maria Arroyo, Elizabeth Chorvinsky, Karima Abutaleb, Geovanny F Perez, Seth Wolf, Xilei Xuchen, Jered Weinstock, Maria J Gutierrez, Marcos Pérez-Losada, Dinesh K Pillai, and Gustavo Nino

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Innate IFN-lambda responses to dsRNA in the human infant airway epithelium and clinical regulatory factors during viral respiratory infections in early life., Kyle Salka, Maria Arroyo, Elizabeth Chorvinsky, Karima Abutaleb, Geovanny F. Perez, Seth Wolf, Xilei Xuchen, Jered Weinstock, Maria J. Gutierrez, Marcos Pérez-Losada, Dinesh K. Pillai, and Gustavo Nino

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Customized Probability of Vaginal Delivery With Induction of Labor and Expectant Management in Nulliparous Women at 39 Weeks of Gestation., Robert M Silver, Madeline Murguia Rice, William A Grobman, Uma M Reddy, Alan T N Tita, Gail Mallett, Kim Hill, Elizabeth A. Thom, Yasser Y El-Sayed, Ronald J Wapner, Dwight J Rouse, George R Saade, John M Thorp, Suneet P Chauhan, Edward K Chien, Brian M Casey, Ronald S Gibbs, Sindhu K Srinivas, Geeta K Swamy, Hyagriv N Simhan, and George A Macones

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Drug Resistance Prediction Using Deep Learning Techniques on HIV-1 Sequence Data., Margaret C Steiner, Keylie M Gibson, and Keith A. Crandall

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Modern Clinician-initiated Clinical Trials to Determine Optimal Therapy for Multidrug-resistant Gram-negative Infections., Adam G Stewart, Patrick N A Harris, Mark Chatfield, Scott R. Evans, David van Duin, and David L Paterson

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Consumption of Beverages Containing Low-Calorie Sweeteners, Diet, and Cardiometabolic Health in Youth With Type 2 Diabetes., Allison C. Sylvetsky, Avinash Chandran, Sameera A. Talegawkar, Jean A. Welsh, Kimberly Drews, and Laure El Ghormli

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Fetoscopic Tracheal Occlusion for Severe Congenital Diaphragmatic Hernia: The State of the Evidence., Elizabeth A. Thom

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Variants in the Kisspeptin-GnRH Pathway Modulate the Hormonal Profile and Reproductive Outcomes., Camila Martins Trevisan, Michel Satya Naslavsky, Frederico Monfardini, Jaqueline Wang, Mayana Zatz, Carla Peluso, Renata Pellegrino, Fernanda Mafra, Hakon Hakonarson, Frederico Moraes Ferreira, Helder Nakaya, Denise Maria Christofolini, Erik Montagna, Keith A. Crandall, Caio Parente Barbosa, and Bianca Bianco

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Long-term outcomes in Juvenile Myositis patients., Vladislav Tsaltskan, Annette Aldous, Sam Serafi, Anna Yakovleva, Heidi Sami, Gulnara Mamyrova, Ira N. Targoff, Adam Schiffenbauer, Frederick W. Miller, Samuel J. Simmens, Rodolfo Curiel, Olcay Y. Jones, and Lisa G. Rider

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Variable selection methods for identifying predictor interactions in data with repeatedly measured binary outcomes., Bethany J Wolf, Yunyun Jiang, Sylvia H Wilson, and Jim C Oates

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The Cancer Microbiome: Distinguishing Direct and Indirect Effects Requires a Systemic View., Joao B. Xavier, Vincent B. Young, Joseph Skufca, Fiona Ginty, Traci Testerman, Alexander T. Pearson, Paul Macklin, Amir Mitchell, Ilya Shmulevich, Lei Xie, J Gregory Caporaso, Keith A. Crandall, Nicole L. Simone, Filipa Godoy-Vitorino, Timothy J. Griffin, Katrine L. Whiteson, Heather H. Gustafson, Daniel J. Slade, Thomas M. Schmidt, Marina R S Walther-Antonio, Tal Korem, Bobbie-Jo M. Webb-Robertson, Mark P. Styczynski, W Evan Johnson, Christian Jobin, Jason M. Ridlon, Andrew Y. Koh, Michael Yu, Libusha Kelly, and Jennifer A. Wargo

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The effects of environment and ontogeny on the skin microbiome of two Stegastes damselfishes (Pomacentridae) from the eastern Caribbean Sea, R Xavier, A Pereira, A Pagan, G C. Hendrick, M D. Nicholson, D Rosado, M C. Soares, and Marcos Perez-Losada

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Sequential Multiple Assignment Randomized Trials for COMparing Personalized Antibiotic StrategieS (SMART COMPASS): Design Considerations, Xiaoyan Yin, Toshimitsu Hamasaki, and Scott R. Evans

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Sequential Multiple Assignment Randomized Trials for COMparing Personalized Antibiotic StrategieS (SMART COMPASS): Design Considerations, Xiaoyan Yin, Toshimitsu Hamasaki, and Scott R. Evans

Submissions from 2019

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Urinary angiotensinogen antedates the development of stage 3 CKD in patients with type 1 diabetes mellitus, Sheeba Ba Aqeel, Minghao Ye, Jan Wysocki, Alejandro Sanchez, Ahmed Khattab, Enrique Lores, Alfred Rademaker, Xiaoyu Gao, Ionut Bebu, Robert G. Nelson, Mark Molitch, Daniel Batlle, and Diabetes Control Complications Trual (DCCT)/ Epidemiology of Diabetes Interventions Complications (EDIC) Study

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Interim Monitoring for Futility in Clinical Trials With Two Co-Primary Endpoints Using Prediction, Koko Asakura, Scott R. Evans, and Toshimitsu Hamasaki

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Serum apolipoproteins and apolipoprotein-defined lipoprotein subclasses: a hypothesis-generating prospective study of cardiovascular events in T1D., Arpita Basu, Ionut Bebu, Alicia J Jenkins, Julie A Stoner, Ying Zhang, Richard L Klein, Maria F Lopes-Virella, W Timothy Garvey, Matthew J Budoff, Petar Alaupovic, and Timothy J Lyons

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Telescope: Characterization of the retrotranscriptome by accurate estimation of transposable element expression, Matthew L. Bendall, Miguel de Mulder, Luis Pedro Iniguez, Aaron Lecanda-Sanchez, Marcos Perez-Losada, Mario A. Ostrowski, R. Brad Jones, Lubbertus C. F. Mulder, Gustavo Reyes-Teran, Keith A. Crandall, Christopher E. Ormsby, and Douglas F. Nixon

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2573. Impact of Anaerobic Antibacterial Spectrum on Cystic Fibrosis Lung Microbiome Diversity and Pulmonary Function, Michael Bozzella, Hollis Chaney, Iman Sami, Geovanny Perez, Anastassios Koumbourlis, James Bost, Robert Freishtat, Keith Crandell, and Andrea Hahn

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Rapid bacterial community changes during vermicomposting of grape marc derived from red winemaking, M. G. Brandon, M. Aira, A. R. Kolbe, N. de Andrade, M. Perez-Losada, and J Dominguez

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Frailty and Its Correlates in Adults With Late Life Depression, P J. Brown, S P. Roose, K R. O'Boyle, A Ciarleglio, B Mass, K C. Igwe, S Chung, S Gomez, M Naqvi, A M. Brickman, and B R. Rutherford

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2168. Comparison of Rapid Diagnostic Tests for Bloodstream Infections Using Desirability of Outcome Ranking Management of Antimicrobial Therapy (DOOR-MAT), Kimberly C. Claeys, Teri Hopkins, Zegbeh Kpadeh-Rogers, Yunyun Jiang, Scott R. Evans, J Kristie Johnson, and Surbhi Leekha

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151. Comparing the Clinical Utility of Rapid Diagnostic Tests for Gram-Negative Bloodstream Infection Using a Desirability of Outcomes Ranking, Kimberly C. Claeys, Kathryn Schlaffer, Zegbeh Kpadeh-Rogers, Yunyun Jiang, Scott R. Evans, J Kristie Johnson, and Surbhi Leekha

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Simultaneous Evaluation of Diagnostic Assays for Pharyngeal and Rectal Neisseria gonorrhoeae and Chlamydia trachomatis Using a Master Protocol, S B. Doernberg, L Komarow, T T T. Tran, Z Sund, M W. Pandori, D Jensen, E L. Tsalik, C D. Deal, H F. Chambers, V G. Fowler, S R. Evans, R Patel, J D. Klausner, and Antibacterrial Resistance Leadership Group