Early Postnatal Polymerase Chain Reaction Testing in the Identification of Perinatal Transmission of Hepatitis C Virus

Authors

Mona Prasad, Department of Obstetrics and Gynecology of the Ohio State University, Columbus, Ohio, USA.
Grecio J. Sandoval, George Washington University Biostatistics Center, Washington, DC, USA.
George R. Saade, Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas, USA.
Brenna L. Hughes, Brown University, Women and Infants Hospital of Rhode Island, Providence, Rhode Island, USA.
Rebecca G. Clifton, George Washington University Biostatistics Center, Washington, DC, USA.
Uma M. Reddy, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA.
Anna Bartholomew, Department of Obstetrics and Gynecology of the Ohio State University, Columbus, Ohio, USA.
Ashley Salazar, Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas, USA.
Edward K. Chien, Department of Obstetrics and Gynecology, Case Western Reserve University, Cleveland, Ohio, USA.
Alan T. Tita, Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
John M. Thorp, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Torri D. Metz, Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, Utah, USA.
Ronald J. Wapner, Department of Obstetrics and Gyneology, Columbia University, New York, New York, USA.
Vishakha Sabharwal, Department of Pediatrics, Boston Medical Center, Boston, Massachusetts, USA.
Hyagriv N. Simhan, University of Pittsburgh, Magee Womens Hospital, Pittsburgh, Pennsylvania, USA.
Geeta K. Swamy, Department of Obstetrics and Gynecology, Duke University, Durham, North Carolina, USA.
Kent D. Heyborne, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado, USA.
Baha M. Sibai, Department of Obstetrics and Gynecology, University of Texas Health Science Center at Houston-Children's Memorial Hermann Hospital, Houston, Texas, USA.
William A. Grobman, Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois, USA.
Yasser Y. El-Sayed, Department of Obstetrics and Gynecology, Stanford University, Stanford, California, USA.
Brian M. Casey, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Samuel Parry, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
George A. Macones, Department of Womens Health, University of Texas at Austin, Austin, Texas, USA.

Document Type

Journal Article

Publication Date

7-14-2025

Journal

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

DOI

10.1093/cid/ciaf266

Keywords

HCV; PCR; hepatitis C virus; pediatric screening; perinatal transmission

Abstract

In this study, a single hepatitis C virus (HCV) RNA at 2-6 months was sensitive and specific (86.7% and 95% confidence interval [CI], 62.1%-96.3% and 100% and 95% CI, 98.8%-100%, respectively) in identifying perinatal transmission of HCV. No cases of perinatal infection requiring treatment were missed.

APA Citation

Prasad, Mona; Sandoval, Grecio J.; Saade, George R.; Hughes, Brenna L.; Clifton, Rebecca G.; Reddy, Uma M.; Bartholomew, Anna; Salazar, Ashley; Chien, Edward K.; Tita, Alan T.; Thorp, John M.; Metz, Torri D.; Wapner, Ronald J.; Sabharwal, Vishakha; Simhan, Hyagriv N.; Swamy, Geeta K.; Heyborne, Kent D.; Sibai, Baha M.; Grobman, William A.; El-Sayed, Yasser Y.; Casey, Brian M.; Parry, Samuel; and Macones, George A., "Early Postnatal Polymerase Chain Reaction Testing in the Identification of Perinatal Transmission of Hepatitis C Virus" (2025). GW Authored Works. Paper 7600.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/7600

Department

Biostatistics and Bioinformatics