Early Postnatal Polymerase Chain Reaction Testing in the Identification of Perinatal Transmission of Hepatitis C Virus

Authors

• Mona Prasad, Department of Obstetrics and Gynecology of the Ohio State University, Columbus, Ohio, USA.
• Grecio J. Sandoval, George Washington University Biostatistics Center, Washington, DC, USA.
• George R. Saade, Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas, USA.
• Brenna L. Hughes, Brown University, Women and Infants Hospital of Rhode Island, Providence, Rhode Island, USA.
• Rebecca G. Clifton, George Washington University Biostatistics Center, Washington, DC, USA.
• Uma M. Reddy, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA.
• Anna Bartholomew, Department of Obstetrics and Gynecology of the Ohio State University, Columbus, Ohio, USA.
• Ashley Salazar, Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas, USA.
• Edward K. Chien, Department of Obstetrics and Gynecology, Case Western Reserve University, Cleveland, Ohio, USA.
• Alan T. Tita, Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
• John M. Thorp, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
• Torri D. Metz, Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, Utah, USA.
• Ronald J. Wapner, Department of Obstetrics and Gyneology, Columbia University, New York, New York, USA.
• Vishakha Sabharwal, Department of Pediatrics, Boston Medical Center, Boston, Massachusetts, USA.
• Hyagriv N. Simhan, University of Pittsburgh, Magee Womens Hospital, Pittsburgh, Pennsylvania, USA.
• Geeta K. Swamy, Department of Obstetrics and Gynecology, Duke University, Durham, North Carolina, USA.
• Kent D. Heyborne, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado, USA.
• Baha M. Sibai, Department of Obstetrics and Gynecology, University of Texas Health Science Center at Houston-Children's Memorial Hermann Hospital, Houston, Texas, USA.
• William A. Grobman, Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois, USA.
• Yasser Y. El-Sayed, Department of Obstetrics and Gynecology, Stanford University, Stanford, California, USA.
• Brian M. Casey, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
• Samuel Parry, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
• George A. Macones, Department of Womens Health, University of Texas at Austin, Austin, Texas, USA.

Document Type

Journal Article

Publication Date

7-14-2025

Journal

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

DOI

10.1093/cid/ciaf266

Keywords

HCV; PCR; hepatitis C virus; pediatric screening; perinatal transmission

Abstract

In this study, a single hepatitis C virus (HCV) RNA at 2-6 months was sensitive and specific (86.7% and 95% confidence interval [CI], 62.1%-96.3% and 100% and 95% CI, 98.8%-100%, respectively) in identifying perinatal transmission of HCV. No cases of perinatal infection requiring treatment were missed.

APA Citation

Prasad, Mona; Sandoval, Grecio J.; Saade, George R.; Hughes, Brenna L.; Clifton, Rebecca G.; Reddy, Uma M.; Bartholomew, Anna; Salazar, Ashley; Chien, Edward K.; Tita, Alan T.; Thorp, John M.; Metz, Torri D.; Wapner, Ronald J.; Sabharwal, Vishakha; Simhan, Hyagriv N.; Swamy, Geeta K.; Heyborne, Kent D.; Sibai, Baha M.; Grobman, William A.; El-Sayed, Yasser Y.; Casey, Brian M.; Parry, Samuel; and Macones, George A., "Early Postnatal Polymerase Chain Reaction Testing in the Identification of Perinatal Transmission of Hepatitis C Virus" (2025). GW Authored Works. Paper 7600.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/7600

Department

Biostatistics and Bioinformatics