Obstructive sleep apnea, glycemic control, and cardiovascular risk in young adults with youth-onset type 2 diabetes: results from the TODAY study

Document Type

Journal Article

Publication Date

6-26-2025

Journal

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

DOI

10.5664/jcsm.11784

Keywords

glycemic control; obese; obstructive sleep apnea; polysomnogram; type 2 diabetes; β-cell function

Abstract

STUDY OBJECTIVES: Obstructive sleep apnea (OSA) is a common comorbidity in type 2 diabetes and has been associated with poor glycemic control, but few data exist in youth-onset type 2 diabetes. We evaluated the prevalence of OSA and its associations with metabolic control and cardiovascular risk in young adults with pediatric type 2 diabetes. METHODS: OSA presence and severity was assessed by polysomnography in 114 participants in the TODAY Study (Treatment Options for type 2 Diabetes in Adolescents and Youth) (mean: age 23.5 years, diabetes duration 10 years, BMI 35.3 kg/m). HbA1c, β-cell function, and diabetes-related complications were collected in the TODAY cohort. Adjusted regression models evaluated relationships between OSA and outcomes. RESULTS: The prevalence of OSA in TODAY was 38.6%. OSA was not associated with HbA1c, loss of metabolic control, or diabetes-related complications in this cohort. CONCLUSIONS: Despite nearly 10 years of poorly controlled diabetes, young adults with youth-onset type 2 diabetes had a moderate prevalence of OSA. Severity of OSA was not associated with loss of glycemic control or diabetes-related complications in the TODAY cohort. The prevalence of OSA was lower than that reported in adults with prediabetes/early type 2 diabetes. CLINICAL TRIAL REGISTRATION: Registry: ClinicalTrials.gov; Name: TODAY Study; Identifier: NCT00081328.

Department

Biostatistics and Bioinformatics

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