Sex-dependent epigenetic disruption of YY1 binding by prenatal BPA exposure downregulates Matr3 and alters Agap1 splicing in the offspring hippocampus

Authors

• Pattanachat Lertpeerapan, The Ph.D. program in Clinical Biochemistry and Molecular Medicine, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.
• Songphon Kanlayaprasit, Chulalongkorn Autism Research and Innovation Center of Excellence (ChulaACE), Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.
• Surangrat Thongkorn, Department of Biotechnology and Biomedicine (DTU Bioengineering), Technical University of Denmark, 2800, Kgs. Lyngby, Denmark.
• Kasidit Kasitipradit, The Ph.D. program in Clinical Biochemistry and Molecular Medicine, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.
• Pawinee Panjabud, The Ph.D. program in Clinical Biochemistry and Molecular Medicine, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.
• Kwanjira Songsritaya, The M.Sc. Program in Clinical Biochemistry and Molecular Medicine, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.
• Thanawin Jantheang, The Ph.D. program in Clinical Biochemistry and Molecular Medicine, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.
• Masanobu Morita, Department of Environmental Medicine and Molecular Toxicology, Tohoku University Graduate School of Medicine, Miyagi, 980-8575, Japan.
• Takaaki Akaike, Department of Environmental Medicine and Molecular Toxicology, Tohoku University Graduate School of Medicine, Miyagi, 980-8575, Japan.
• Valerie W. Hu, Department of Biochemistry and Molecular Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, DC, 20037, USA.
• Depicha Jindatip, Department of Anatomy, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.
• Thanit Saeliw, Chulalongkorn Autism Research and Innovation Center of Excellence (ChulaACE), Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.
• Tewarit Sarachana, Chulalongkorn Autism Research and Innovation Center of Excellence (ChulaACE), Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand. tewarit.sa@chula.ac.th.

Document Type

Journal Article

Publication Date

8-11-2025

Journal

Biology of sex differences

Volume

16

Issue

1

DOI

10.1186/s13293-025-00744-1

Keywords

Agap1; Matr3; Alternative splicing; Autism spectrum disorder; Bisphenol A; Interactome; RNA-binding protein; Sex difference; Transcription factor YY1; Transcriptome

APA Citation

Lertpeerapan, Pattanachat; Kanlayaprasit, Songphon; Thongkorn, Surangrat; Kasitipradit, Kasidit; Panjabud, Pawinee; Songsritaya, Kwanjira; Jantheang, Thanawin; Morita, Masanobu; Akaike, Takaaki; Hu, Valerie W.; Jindatip, Depicha; Saeliw, Thanit; and Sarachana, Tewarit, "Sex-dependent epigenetic disruption of YY1 binding by prenatal BPA exposure downregulates Matr3 and alters Agap1 splicing in the offspring hippocampus" (2025). GW Authored Works. Paper 7787.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/7787

Department

Biochemistry and Molecular Medicine