Sex-dependent epigenetic disruption of YY1 binding by prenatal BPA exposure downregulates Matr3 and alters Agap1 splicing in the offspring hippocampus

Authors

Pattanachat Lertpeerapan, The Ph.D. program in Clinical Biochemistry and Molecular Medicine, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.
Songphon Kanlayaprasit, Chulalongkorn Autism Research and Innovation Center of Excellence (ChulaACE), Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.
Surangrat Thongkorn, Department of Biotechnology and Biomedicine (DTU Bioengineering), Technical University of Denmark, 2800, Kgs. Lyngby, Denmark.
Kasidit Kasitipradit, The Ph.D. program in Clinical Biochemistry and Molecular Medicine, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.
Pawinee Panjabud, The Ph.D. program in Clinical Biochemistry and Molecular Medicine, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.
Kwanjira Songsritaya, The M.Sc. Program in Clinical Biochemistry and Molecular Medicine, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.
Thanawin Jantheang, The Ph.D. program in Clinical Biochemistry and Molecular Medicine, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.
Masanobu Morita, Department of Environmental Medicine and Molecular Toxicology, Tohoku University Graduate School of Medicine, Miyagi, 980-8575, Japan.
Takaaki Akaike, Department of Environmental Medicine and Molecular Toxicology, Tohoku University Graduate School of Medicine, Miyagi, 980-8575, Japan.
Valerie W. Hu, Department of Biochemistry and Molecular Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, DC, 20037, USA.
Depicha Jindatip, Department of Anatomy, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.
Thanit Saeliw, Chulalongkorn Autism Research and Innovation Center of Excellence (ChulaACE), Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.
Tewarit Sarachana, Chulalongkorn Autism Research and Innovation Center of Excellence (ChulaACE), Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand. tewarit.sa@chula.ac.th.

Document Type

Journal Article

Publication Date

8-11-2025

Journal

Biology of sex differences

Volume

16

Issue

1

DOI

10.1186/s13293-025-00744-1

Keywords

Agap1; Matr3; Alternative splicing; Autism spectrum disorder; Bisphenol A; Interactome; RNA-binding protein; Sex difference; Transcription factor YY1; Transcriptome

APA Citation

Lertpeerapan, Pattanachat; Kanlayaprasit, Songphon; Thongkorn, Surangrat; Kasitipradit, Kasidit; Panjabud, Pawinee; Songsritaya, Kwanjira; Jantheang, Thanawin; Morita, Masanobu; Akaike, Takaaki; Hu, Valerie W.; Jindatip, Depicha; Saeliw, Thanit; and Sarachana, Tewarit, "Sex-dependent epigenetic disruption of YY1 binding by prenatal BPA exposure downregulates Matr3 and alters Agap1 splicing in the offspring hippocampus" (2025). GW Authored Works. Paper 7787.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/7787

Department

Biochemistry and Molecular Medicine