Whole Genome Analysis of a Schistosomiasis-Transmitting Freshwater Snail.

Authors

Coen M Adema
LaDeana W Hillier
Catherine S Jones
Eric S Loker
Matty Knight, George Washington UniversityFollow
Patrick Minx
+several additional authors

Document Type

Journal Article

Publication Date

5-16-2017

Journal

Nature Communications

Volume

8

DOI

10.1038/ncomms15451

Abstract

Biomphalaria snails are instrumental in transmission of the human blood fluke Schistosoma mansoni. With the World Health Organization's goal to eliminate schistosomiasis as a global health problem by 2025, there is now renewed emphasis on snail control. Here, we characterize the genome of Biomphalaria glabrata, a lophotrochozoan protostome, and provide timely and important information on snail biology. We describe aspects of phero-perception, stress responses, immune function and regulation of gene expression that support the persistence of B. glabrata in the field and may define this species as a suitable snail host for S. mansoni. We identify several potential targets for developing novel control measures aimed at reducing snail-mediated transmission of schistosomiasis.

Comments

Reproduced with permission of Macmillan Publishers Ltd. Nature Communications

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.

APA Citation

Adema, C., Hillier, L., Jones, C., Loker, E., Knight, M., Minx, P., & +several additional authors (2017). Whole Genome Analysis of a Schistosomiasis-Transmitting Freshwater Snail.. Nature Communications, 8 (). http://dx.doi.org/10.1038/ncomms15451

Peer Reviewed

1

Open Access

1