Document Type
Journal Article
Publication Date
3-2017
Journal
Tumor Biology
DOI
10.1177/1010428317692247
Abstract
Urogenital schistosomiasis is a neglected tropical disease that can lead to bladder cancer. How urogenital schistosomiasis induces carcinogenesis remains unclear, although there is evidence that the human blood fluke Schistosoma haematobium, the infectious agent of urogenital schistosomiasis, releases estradiol-like metabolites. These kind of compounds have been implicated in other cancers. Aiming for enhanced understanding of the pathogenesis of the urogenital schistosomiasisinduced bladder cancer, here we review, interpret, and discuss findings of estradiol-like metabolites detected in both the parasite and in the human urine during urogenital schistosomiasis. Moreover, we predict pathways and enzymes that are involved in the production of these metabolites emphasizing their potential effects on the dysregulation of the tumor suppressor gene p53 expression during urogenital schistosomiasis. Enhanced understanding of these potential carcinogens may not only shed light on urogenital schistosomiasis-induced neoplasia of the bladder, but would also facilitate development of interventions and biomarkers for this and other infection-associated cancers at large.
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License
APA Citation
Vale, N., Gouveia, M., Rinaldi, G., Santos, J., Santos, L. L., Brindley, P. J., & Correia da Costa, J. (2017). The role of estradiol metabolism in urogenital schistosomiasis-induced bladder cancer. Tumor Biology, (). http://dx.doi.org/10.1177/1010428317692247
Peer Reviewed
1
Open Access
1
Included in
Cancer Biology Commons, Medical Immunology Commons, Medical Microbiology Commons, Neoplasms Commons, Tropical Medicine Commons
Comments
Reproduced with permission of Sage Journals. Tumor Biology