Document Type
Journal Article
Publication Date
3-13-2017
Journal
Nature Communications
Volume
8
Inclusive Pages
14693
DOI
10.1038/ncomms14693
Abstract
Eggs produced by the mature female parasite are responsible for the pathogenesis and transmission of schistosomiasis. Female schistosomes rely on a unique male-induced strategy to accomplish reproductive development, a process that is incompletely understood. Here we map detailed transcriptomic profiles of male and female Schistosoma japonicum across eight time points throughout the sexual developmental process from pairing to maturation. The dynamic gene expression pattern data reveal clear sex-related characteristics, indicative of an unambiguous functional division between males and females during their interplay. Cluster analysis, in situ hybridization and RNAi assays indicate that males likely use biogenic amine neurotransmitters through the nervous system to control and maintain pairing with females. In addition, the analyses indicate that reproductive development of females involves an insect-like hormonal regulation. These data sets and analyses serve as a foundation for deeper study of sexual development in this pathogen and identification of novel anti-schistosomal interventions.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
APA Citation
Wang, J., Yu, Y., Shen, H., Qing, T., Zheng, Y., Li, Q., Mo, X., Wang, S., Li, N., Chai, R., Xu, B., Liu, M., Brindley, P., McManus, D., Feng, Z., Shi, L., & Hu, W. (2017). Dynamic transcriptomes identify biogenic amines and insect-like hormonal regulation for mediating reproduction in Schistosoma japonicum.. Nature Communications, 8 (). http://dx.doi.org/10.1038/ncomms14693
Peer Reviewed
1
Open Access
1
Included in
Medical Immunology Commons, Medical Microbiology Commons, Parasitic Diseases Commons, Parasitology Commons, Tropical Medicine Commons
Comments
Reproduced with permission of Macmillan Publishers Limited. Nature Communications