Document Type
Journal Article
Publication Date
10-1-2015
Journal
PLoS Pathogens
Volume
11
Issue
10
Inclusive Pages
Article number e1005209
DOI
10.1371/journal.ppat.1005209
Keywords
Carcinogenesis--metabolism; Helminth Proteins--metabolism; Intercellular Signaling Peptides and Proteins--metabolism; Opisthorchiasis--complications; Opisthorchis--metabolism; Wound Healing--physiology
Abstract
Infection with the human liver fluke Opisthorchis viverrini induces cancer of the bile ducts, cholangiocarcinoma (CCA). Injury from feeding activities of this parasite within the human biliary tree causes extensive lesions, wounds that undergo protracted cycles of healing, and re-injury over years of chronic infection. We show that O. viverrini secreted proteins accelerated wound resolution in human cholangiocytes, an outcome that was compromised following silencing of expression of the fluke-derived gene encoding the granulin-like growth factor, Ov-GRN-1. Recombinant Ov-GRN-1 induced angiogenesis and accelerated mouse wound healing. Ov-GRN-1 was internalized by human cholangiocytes and induced gene and protein expression changes associated with wound healing and cancer pathways. Given the notable but seemingly paradoxical properties of liver fluke granulin in promoting not only wound healing but also a carcinogenic microenvironment, Ov-GRN-1 likely holds marked potential as a therapeutic wound-healing agent and as a vaccine against an infection-induced cancer of major public health significance in the developing world.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
APA Citation
Smout MJ, Sotillo J, Laha T, Papatpremsiri A, Rinaldi G, Pimenta RN, et al. (2015) Carcinogenic Parasite Secretes Growth Factor That Accelerates Wound Healing and Potentially Promotes Neoplasia. PLoS Pathog 11(10): e1005209. doi:10.1371/journal.ppat.1005209
Peer Reviewed
1
Open Access
1
Included in
Medical Immunology Commons, Medical Microbiology Commons, Parasitic Diseases Commons, Parasitology Commons
Comments
This article reproduced with permission of PlosOne. PLOP Pathogens