Document Type
Journal Article
Publication Date
9-2015
Journal
Frontiers in Immunology
Volume
6
Inclusive Pages
506
DOI
10.3389/fimmu.2015.00506
Abstract
HIV’s ability to establish latent reservoirs of reactivation-competent virus is the major barrier to cure. “Shock and kill” methods consisting of latency reversing agents (LRAs) followed by elimination of reactivating cells through cytopathic effects are under active development. However, the clinical efficacy of LRAs remains to be established. Moreover, recent studies indicate that reservoirs may not be reduced efficiently by either viral cytopathic or CD8+ T-cell-mediated mechanisms. In this perspective, we highlight challenges to T-cell-mediated elimination of HIV reservoirs, including characteristics of responding T-cells, aspects of the cellular reservoirs and properties of the latent virus itself. We also discuss potential strategies to overcome these challenges by targeting the antiviral activity of T-cells towards appropriate viral antigens following latency.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
APA Citation
Brockman, M.A., Jones, R.B., Brumme, Z.L. (2015). Challenges and opportunities for T cell-mediated strategies to eliminate HIV reservoirs. Frontiers in Immunology, 6:506. doi: 10.3389/fimmu.2015.00506
Peer Reviewed
1
Open Access
1
Comments
This is a provisional PDF/accepted manuscript. Final version of record will be available shortly.
Reproduced with permission of Frontiers Media. Frontiers in Immunology.