Document Type
Journal Article
Publication Date
6-10-2014
Journal
mBio
Volume
Volume 5, Issue 3
Abstract
A small percentage of HIV-infected subjects (2 to 15%) are able to control disease progression for many years without antiretroviral therapy. Years of intense studies of virologic and immunologic mechanisms of disease control in such individuals yielded a number of possible host genes that could be responsible for the preservation of immune functions, from immune surveillance genes, chemokines, or their receptors to anti-HIV restriction factors. A recent mBiopaper by Rappocciolo et al. (G. Rappocciolo, M. Jais, P. Piazza, T. A. Reinhart, S. J. Berendam, L. Garcia-Exposito, P. Gupta, and C. R. Rinaldo, mBio 5:e01031-13, 2014) describes another potential factor controlling disease progression: cholesterol levels in antigen-presenting cells. In this commentary, we provide a brief background of the role of cholesterol in HIV infection, discuss the results of the study by Rappocciolo et al., and present the implications of their findings.
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 License.
APA Citation
Prasad, V.R., Bukrinsky, M.I. (2014). New clues to understanding HIV nonprogressors: Low cholesterol blocks HIV trans infection. mBio, 5(3).
Peer Reviewed
1
Open Access
1
Comments
Reproduced with permission of mBio.