Lichen Sclerosus: An autoimmunopathogenic and genomic enigma with emerging genetic and immune targets.

Authors

Davis A Tran, George Washington University
Xiaohui Tan, George Washington University
Charles J Macri, George Washington University
Andrew T Goldstein, George Washington University
Sidney W Fu, George Washington University

Document Type

Journal Article

Publication Date

1-1-2019

Journal

Int J Biol Sci

Volume

15

Issue

7

DOI

10.7150/ijbs.34613

Abstract

Lichen sclerosus (LS) is an inflammatory dermatosis with a predilection for anogenital skin. Developing lesions lead to vulvar pain and sexual dysfunction, with a significant loss of structural anatomical architecture, sclerosis, and increased risk of malignancy. Onset may occur at any age in both sexes, but typically affects more females than males, presenting in a bimodal fashion among pre-pubertal children and middle-aged adults. A definitive cure remains elusive as the exact pathogenesis of LS remains unknown. A general review of LS, histologic challenges, along with amounting support for LS as an autoimmune disease with preference for a T

Comments

This is an open access PubMed Central article.

APA Citation

Tran, D., Tan, X., Macri, C., Goldstein, A., & Fu, S. (2019). Lichen Sclerosus: An autoimmunopathogenic and genomic enigma with emerging genetic and immune targets.. Int J Biol Sci, 15 (7). http://dx.doi.org/10.7150/ijbs.34613

Peer Reviewed

1

Open Access

1