The protein acetylase GCN5L1 modulates hepatic fatty acid oxidation activity via acetylation of the mitochondrial β-oxidation enzyme HADHA.

Authors

Dharendra Thapa
Kaiyuan Wu
Michael W Stoner
Bingxian Xie
Manling Zhang
Janet R Manning
Zhongping Lu, George Washington University
Jian H Li
Yong Chen
Marjan Gucek
Martin P Playford
Nehal N Mehta
Daniel Harmon
Robert M O'Doherty
Michael J Jurczak
Michael N Sack
Iain Scott

Document Type

Journal Article

Publication Date

11-16-2018

Journal

The Journal of biological chemistry

Volume

293

Issue

46

Inclusive Pages

17676-17684

DOI

10.1074/jbc.AC118.005462

Keywords

Acetylation; Animals; Diet, High-Fat; Fatty Acids; Fatty Liver; Hep G2 Cells; Humans; Lysine; Mice, Inbred C57BL; Mice, Knockout; Mitochondrial Trifunctional Protein, alpha Subunit; Nerve Tissue Proteins; Oxidation-Reduction; Protein Isoforms; Protein Processing, Post-Translational; Proteomics; Sirtuin 3

Comments

This is an open access PubMed Central article.

APA Citation

Thapa, D., Wu, K., Stoner, M., Xie, B., Zhang, M., Manning, J., Lu, Z., Li, J., Chen, Y., Gucek, M., Playford, M., Mehta, N., Harmon, D., O'Doherty, R., Jurczak, M., Sack, M., & Scott, I. (2018). The protein acetylase GCN5L1 modulates hepatic fatty acid oxidation activity via acetylation of the mitochondrial β-oxidation enzyme HADHA.. The Journal of biological chemistry, 293 (46). http://dx.doi.org/10.1074/jbc.AC118.005462

Peer Reviewed

1

Open Access

1