Stevioside inhibits experimental fibrosis by down-regulating profibrotic Smad pathways and blocking hepatic stellate cell activation.

Authors

Sael Casas-Grajales
Diana Alvarez-Suarez
Erika Ramos-Tovar
Laura Dayana Buendía-Montaño
Karina Reyes-Gordillo, George Washington University
Javier Camacho
Víctor Tsutsumi
M Raj Lakshman, George Washington University
Pablo Muriel

Document Type

Journal Article

Publication Date

6-1-2019

Journal

Basic & Clinical Pharmacology & Toxicology

Volume

124

Issue

6

Inclusive Pages

670-680

DOI

10.1111/bcpt.13194

Keywords

Actins; Animals; Cell Line; Collagen Type I; Collagenases; Deoxycytosine Nucleotides; Diterpenes, Kaurane; Down-Regulation; Fibrosis; Glucosides; Hepatic Stellate Cells; Humans; Liver; Liver Cirrhosis; Lymphokines; MAP Kinase Signaling System; Male; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-myc; Rats; Rats, Wistar; Signal Transduction; Smad Proteins; Thioacetamide; Transforming Growth Factor beta1; Up-Regulation

Comments

Epub 2019 Jan 10

APA Citation

Casas-Grajales, S., Alvarez-Suarez, D., Ramos-Tovar, E., Dayana Buendía-Montaño, L., Reyes-Gordillo, K., Camacho, J., Tsutsumi, V., Lakshman, M., & Muriel, P. (2019). Stevioside inhibits experimental fibrosis by down-regulating profibrotic Smad pathways and blocking hepatic stellate cell activation.. Basic & Clinical Pharmacology & Toxicology, 124 (6). http://dx.doi.org/10.1111/bcpt.13194

Peer Reviewed

1