Relapsed rhabdoid tumours and other non-nephroblastoma childhood and adolescent kidney tumours: perspectives from the HARMONICA collaboration

Authors

• Michael V. Ortiz, Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York City, NY, USA. ortizm2@mskcc.org.
• Francis S. Wens, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
• Andrew L. Hong, Department of Pediatrics, Emory University School of Medicine, and Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, USA.
• Paola Quarello, Pediatric Onco-Hematology, Stem Cell Transplantation and Cellular Therapy Division, Regina Margherita Children's Hospital, Turin, Italy.
• Arnauld C. Verschuur, Department of Pediatric Hemato-Oncology, La Timone Childrens Hospital, APHM, Marseille, France.
• Elisabeth T. Tracy, Division of Pediatric Surgery, UNC Children's Hospital, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
• Najat C. Daw, Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
• Jeffrey S. Dome, Center for Cancer and Blood Disorders, Children's National Hospital and Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
• Amy L. Walz, Department of Pediatrics, Division of Hematology, Oncology, Neuro-Oncology, and Stem Cell Transplant, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
• Julia Sprokkerieft, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
• Godelieve A. Tytgat, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
• Alex Kentsis, Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York City, NY, USA.
• Jaime Libes-Bander, Department of Pediatric Hematology-Oncology, Arnold Palmer Hospital for Children, Orlando, FL, USA.
• Peter J. Schoettler, Department of Pediatrics and Adolescent Medicine, Division of Hematology-Oncology, Mayo Clinic, Rochester, MN, USA.
• Daniela Perotti, Predictive Medicine: Molecular Bases of Genetic Risk, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
• Jarno Drost, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
• Rajkumar Venkatramani, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
• James I. Geller, Peckham Center for Cancer and Blood Disorders, Rady Children's Hospital, San Diego, CA, Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.
• Marry M. van den Heuvel-Eibrink, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.

Document Type

Journal Article

Publication Date

1-2-2026

Journal

Nature reviews. Urology

DOI

10.1038/s41585-025-01117-4

Abstract

Paediatric kidney tumours are generally associated with a favourable survival rate. Most children are diagnosed with Wilms tumour, which has a 90% long-term survival rate with conventional front-line and salvage therapies. However, treatments and outcomes of children with relapsed non-Wilms tumours, such as malignant rhabdoid tumour of the kidney, renal-cell carcinoma (including renal medullary carcinoma), clear-cell sarcoma of the kidney, anaplastic sarcoma of the kidney and congenital mesoblastic nephroma are not well defined. Several of these non-Wilms tumours include unfavourable prognostic subtypes. Currently available data on non-Wilms tumours support advancing studies that pivot from conventional strategies towards disease-specific, biologically driven novel treatments to improve outcomes for each of these rare childhood kidney tumours.

APA Citation

Ortiz, Michael V.; Wens, Francis S.; Hong, Andrew L.; Quarello, Paola; Verschuur, Arnauld C.; Tracy, Elisabeth T.; Daw, Najat C.; Dome, Jeffrey S.; Walz, Amy L.; Sprokkerieft, Julia; Tytgat, Godelieve A.; Kentsis, Alex; Libes-Bander, Jaime; Schoettler, Peter J.; Perotti, Daniela; Drost, Jarno; Venkatramani, Rajkumar; Geller, James I.; and van den Heuvel-Eibrink, Marry M., "Relapsed rhabdoid tumours and other non-nephroblastoma childhood and adolescent kidney tumours: perspectives from the HARMONICA collaboration" (2026). GW Authored Works. Paper 8629.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/8629

Department

Pediatrics