Title

BRCA1 and Breast Cancer: Molecular Mechanisms and Therapeutic Strategies

Document Type

Journal Article

Publication Date

1-1-2022

Journal

Frontiers in cell and developmental biology

Volume

10

DOI

10.3389/fcell.2022.813457

Keywords

BRCA1; breast cancer; detection; gene mutation; personalized and precision medicine (PPM)

Abstract

Breast cancer susceptibility gene 1 () is a tumor suppressor gene, which is mainly involved in the repair of DNA damage, cell cycle regulation, maintenance of genome stability, and other important physiological processes. Mutations or defects in the gene significantly increase the risk of breast, ovarian, prostate, and other cancers in carriers. In this review, we summarized the molecular functions and regulation of and discussed recent insights into the detection and treatment of mutated breast cancer.

Department

Biochemistry and Molecular Medicine

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