BRCA1 and Breast Cancer: Molecular Mechanisms and Therapeutic Strategies

Authors

Xiaoyu Fu, Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
Wei Tan, Department of Biochemistry and Molecular Medicine, The George Washington University School of Medicine and Health Sciences, Washington, DC, United States.
Qibin Song, Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China.
Huadong Pei, Department of Oncology, Georgetown Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, United States.
Juanjuan Li, Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, China.

Document Type

Journal Article

Publication Date

1-1-2022

Journal

Frontiers in cell and developmental biology

Volume

10

DOI

10.3389/fcell.2022.813457

Keywords

BRCA1; breast cancer; detection; gene mutation; personalized and precision medicine (PPM)

Abstract

Breast cancer susceptibility gene 1 () is a tumor suppressor gene, which is mainly involved in the repair of DNA damage, cell cycle regulation, maintenance of genome stability, and other important physiological processes. Mutations or defects in the gene significantly increase the risk of breast, ovarian, prostate, and other cancers in carriers. In this review, we summarized the molecular functions and regulation of and discussed recent insights into the detection and treatment of mutated breast cancer.

APA Citation

Fu, Xiaoyu; Tan, Wei; Song, Qibin; Pei, Huadong; and Li, Juanjuan, "BRCA1 and Breast Cancer: Molecular Mechanisms and Therapeutic Strategies" (2022). GW Authored Works. Paper 666.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/666

Department

Biochemistry and Molecular Medicine