Single Center-Based Real-World Experience on Anti-IL 1 Biological Response Modifiers: A Case Series and Literature Review

Document Type

Journal Article

Publication Date

9-22-2024

Journal

Children (Basel, Switzerland)

Volume

11

Issue

9

DOI

10.3390/children11091146

Keywords

IL-1; anakinra; anti-IL-1 biologic response modifiers; canakinumab; inflammation

Abstract

BACKGROUND: This communication summarizes our single-center experience with the use of anti-IL-1 biologic response modifiers for treating autoimmune and autoinflammatory conditions in children. METHODS: We outline our rationale for the off-label use of anakinra and discuss emerging treatment paradigms that necessitate further research and validation. RESULTS: Anakinra has enabled personalized treatment, whether used as a single agent on an as-needed basis, as part of a background treatment regimen, or in combination with colchicine. Our data also highlight the significance of anakinra in treating post-infectious inflammatory diseases, demonstrating its high efficacy in novel applications such as rheumatic fever and post-viral arthritis. Canakinumab, on the other hand, has provided long-term remission. Both medications were well-tolerated, with no serious adverse effects reported. CONCLUSIONS: Based on our observations and successful outcomes, we advocate for future collaborative efforts to improve access to anti-IL-1 medications to better manage excessive and harmful inflammation in children.

Department

Medicine

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