Chest X-Ray-Based Telemedicine Platform for Pediatric Tuberculosis Diagnosis in Low-Resource Settings: Development and Validation Study

Juan J. Gómez-Valverde, Biomedical Image Technologies, ETSI Telecomunicación, Universidad Politécnica de Madrid, Madrid, Spain.
Ramón Sánchez-Jacob, Department of Radiology, Children's National Hospital & George Washington University School of Medicine, Washington, DC, United States.
José Luis Ribó, Hospital Universitari General de Catalunya, Barcelona, Spain.
H Simon Schaaf, Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Lara García Delgado, Biomedical Image Technologies, ETSI Telecomunicación, Universidad Politécnica de Madrid, Madrid, Spain.
Alicia Hernanz-Lobo, Pediatric Infectious Diseases Department, Gregorio Marañón University Hospital, Madrid, Spain.
Daniel Capellán-Martín, Biomedical Image Technologies, ETSI Telecomunicación, Universidad Politécnica de Madrid, Madrid, Spain.
Ángel Lancharro, Radiología Pediátrica Hospital Materno Infantil Gregorio Marañón, Madrid, Spain.
Orvalho Augusto, Centro de Investigacão em Saúde de Manhiça (CISM), Maputo, Mozambique.
Alberto L. García-Basteiro, Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain.
Begoña Santiago-García, Pediatric Infectious Diseases Department, Gregorio Marañón University Hospital, Madrid, Spain.
Elisa López-Varela, Centro de Investigacão em Saúde de Manhiça (CISM), Maputo, Mozambique.
María J. Ledesma-Carbayo, Biomedical Image Technologies, ETSI Telecomunicación, Universidad Politécnica de Madrid, Madrid, Spain.

Document Type

Journal Article

Publication Date

7-1-2024

Journal

JMIR pediatrics and parenting

Volume

7

DOI

10.2196/51743

Keywords

chest radiograph; low-resource settings; pediatric tuberculosis; screening; telehealth; telemedicine; tuberculosis; usability

Abstract

BACKGROUND: Tuberculosis (TB) remains a major cause of morbidity and death worldwide, with a significant impact on children, especially those under the age of 5 years. The complex diagnosis of pediatric TB, compounded by limited access to more accurate diagnostic tests, underscores the need for improved tools to enhance diagnosis and care in resource-limited settings. OBJECTIVE: This study aims to present a telemedicine web platform, BITScreen PTB (Biomedical Image Technologies Screen for Pediatric Tuberculosis), aimed at improving the evaluation of pulmonary TB in children based on digital chest x-ray (CXR) imaging and clinical information in resource-limited settings. METHODS: The platform was evaluated by 3 independent expert readers through a retrospective assessment of a data set with 218 imaging examinations of children under 3 years of age, selected from a previous study performed in Mozambique. The key aspects assessed were the usability through a standardized questionnaire, the time needed to complete the assessment through the platform, the performance of the readers to identify TB cases based on the CXR, the association between the TB features identified in the CXRs and the initial diagnostic classification, and the interreader agreement of the global assessment and the radiological findings. RESULTS: The platform's usability and user satisfaction were evaluated using a questionnaire, which received an average rating of 4.4 (SD 0.59) out of 5. The average examination completion time ranged from 35 to 110 seconds. In addition, the study on CXR showed low sensitivity (16.3%-28.2%) but high specificity (91.1%-98.2%) in the assessment of the consensus case definition of pediatric TB using the platform. The CXR finding having a stronger association with the initial diagnostic classification was air space opacification (χ21>20.38, P<.001). The study found varying levels of interreader agreement, with moderate/substantial agreement for air space opacification (κ=0.54-0.67) and pleural effusion (κ=0.43-0.72). CONCLUSIONS: Our findings support the promising role of telemedicine platforms such as BITScreen PTB in enhancing pediatric TB diagnosis access, particularly in resource-limited settings. Additionally, these platforms could facilitate the multireader and systematic assessment of CXR in pediatric TB clinical studies.

Department

Radiology

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