Inclisiran siRNA technology in the management of dyslipidemia: A narrative review of clinical trials
Document Type
Journal Article
Publication Date
4-1-2024
Journal
Current problems in cardiology
Volume
49
Issue
4
DOI
10.1016/j.cpcardiol.2024.102419
Keywords
Dyslipidemia; Inclisiran; LDL cholesterol; siRNA therapy
Abstract
RNA interference therapies, particularly small interfering RNAs (siRNAs) like Inclisiran, have shown great potential in managing dyslipidemia, a significant risk factor for cardiovascular disease. Inclisiran targets pro-protein convertasesubtilisin/kexin type 9 (PCSK9) mRNA to reduce low-density lipoprotein cholesterol (LDL-C) levels. This review evaluates Inclisiran's efficacy, safety, and clinical applications in managing dyslipidemia. A review of clinical trials evaluating Inclisiran's efficacy and safety in dyslipidemia management was conducted. PubMed, Embase, Google Scholar and Scopus were searched for relevant trials. Inclusion criteria covered clinical trials in English, published within the last six years, involving human subjects. 12 clinical trials were included in this review, demonstrating Inclisiran's consistent efficacy in reducing LDL-C levels across diverse patient populations, even in statin intolerance or resistance cases. The efficacy was observed over various durations, with some trials extending up to 4 years. Inclisiran demonstrated a favourable safety profile, with mild adverse events reported in most trials, suggesting its potential as a well-tolerated treatment option. Inclisiran's consistent efficacy and safety profile make it a promising option for managing dyslipidemia. Future studies should confirm its long-term effects and explore its clinical implications in diverse patient populations and high-risk scenarios.
APA Citation
Olatunji, Gbolahan; Kokori, Emmanuel; Yusuf, Ismaila Ajayi; Akinmoju, Olumide; Egbunu, Emmanuel; Muogbo, Ifeanyichukwu; Lema, Kaleb; Kanagala, Sai Gutham; Owolabi, Samuel; Abdulbasit, Muili; and Aderinto, Nicholas, "Inclisiran siRNA technology in the management of dyslipidemia: A narrative review of clinical trials" (2024). GW Authored Works. Paper 4836.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/4836
Department
Public Health Student Works