Respiratory Comorbidities Associated with Bronchiectasis in Patients with Common Variable Immunodeficiency in the USIDNET Registry

Authors

Oscar Correa-Jimenez, Allergy and Immunology Unit, Fundación Neumológica Colombiana, Bogotá, D.C., Colombia.
Sonia Restrepo-Gualteros, Department of Pediatrics, Universidad Nacional de Colombia School of Medicine, Bogotá, D.C., Colombia.
Gustavo Nino, Division of Pediatric Pulmonary and Sleep Medicine, Children's National Hospital, Washington, DC, USA.
Charlotte Cunningham-Rundles, Division of Clinical Immunology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kathleen E. Sullivan, Division of Pediatric Allergy and Immunology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Ramsay L. Fuleihan, Division of Allergy & Immunology, Columbia University Irving Medical Center, New York, NY, USA.
Maria J. Gutierrez, Division of Pediatric Allergy, Immunology and Rheumatology, Johns Hopkins University, 600 N. Wolfe St, CMSC 1102, Baltimore, MD, 21287, USA. mgutie10@jh.edu.

Document Type

Journal Article

Publication Date

11-1-2023

Journal

Journal of clinical immunology

Volume

43

Issue

8

DOI

10.1007/s10875-023-01593-6

Keywords

Antibody deficiency; Bronchiectasis; Common variable immunodeficiency; Inborn errors of immunity; Interstitial lung diseases; Pneumonia; Primary immunodeficiency diseases; Respiratory disease; Sinusitis

Abstract

BACKGROUND: Bronchiectasis is a major respiratory complication in patients with common variable immunodeficiency (CVID) and is associated with recurrent pulmonary infections. However, it is unclear whether other infections or non-infectious respiratory conditions are related to its development. OBJECTIVE: To identify respiratory comorbidities associated with bronchiectasis in patients with CVID. METHODS: A total of 1470 CVID patients enrolled in the USIDNET registry were included in a cross-sectional analysis. The primary outcome of our study was to determine the clinical characteristics and other respiratory conditions associated with respiratory comorbidities and physician-reported bronchiectasis. RESULTS: One hundred ninety-seven CVID patients were noted to have bronchiectasis (13.4%). Affected patients were significantly older than patients without bronchiectasis (median age 54 years vs. 49 years, p = 0.0004). These patients also had lower serum IgA (13 mg/dL IQR 60 mg/dL vs. 28.4 mg/dL IQR 66 mg/dL, p = 0.000). Notably, chronic rhinosinusitis (OR = 1.69 95%CI 1.05-2.75), sinusitis (OR = 2.06 95%CI 1.38-3.09), pneumonia (OR = 2.70 95%CI 1.88-3.88), COPD (OR = 2.66 95%CI 1.51-4.67), and interstitial lung disease (OR = 2.34 95%CI 1.41-3.91) were independently associated with the development of bronchiectasis in this population. CONCLUSION: These data suggest that lower and upper respiratory infections, chronic lower airway disease, and interstitial lung diseases are independently associated with bronchiectasis in CVID patients. Further study into predisposing conditions related to the development of bronchiectasis in CVID patients may allow prediction and early intervention strategies to prevent the development of this complication.

APA Citation

Correa-Jimenez, Oscar; Restrepo-Gualteros, Sonia; Nino, Gustavo; Cunningham-Rundles, Charlotte; Sullivan, Kathleen E.; Fuleihan, Ramsay L.; and Gutierrez, Maria J., "Respiratory Comorbidities Associated with Bronchiectasis in Patients with Common Variable Immunodeficiency in the USIDNET Registry" (2023). GW Authored Works. Paper 3867.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/3867

Department

Pediatrics