Title

THE GENERATION AND APPLICATION OF ANTIGEN-SPECIFIC T CELL THERAPIES FOR CANCER AND VIRAL-ASSOCIATED DISEASE

Document Type

Journal Article

Publication Date

2-8-2022

Journal

Molecular therapy : the journal of the American Society of Gene Therapy

DOI

10.1016/j.ymthe.2022.02.002

Keywords

Antigen-specific T cells; adoptive immunotherapy; cancer; manufacturing protocols; virus infection

Abstract

Immunotherapy with antigen-specific T cells is a promising, targeted therapeutic option for patients with cancer as well as for immunocompromised patients with virus infections. In this review, we characterize and compare current manufacturing protocols for the generation of T cells specific to viral and non-viral tumor associated antigens. Specifically, we discuss: (i) the different methodologies to expand virus-specific T cell (VST) and non-viral tumor-associated antigen specific T cell (TAA-T) products, (ii) the immunological principles involved when developing such manufacturing protocols and (iii) proposed standardized methodologies for the generation of polyclonal, polyfunctional antigen-specific T cells irrespective of donor source. Ex vivo-expanded cells have been safely administered to treat numerous patients with virus-associated malignancies, hematologic malignancies, and solid tumors. Hence, we have performed a comprehensive review of the clinical trial results evaluating the safety, feasibility, and efficacy of these products in the clinic. In summary, this review seeks to provide new insights regarding antigen-specific T cell technology to benefit a rapidly expanding T cell therapy field.

Department

Microbiology, Immunology, and Tropical Medicine

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