THE GENERATION AND APPLICATION OF ANTIGEN-SPECIFIC T CELL THERAPIES FOR CANCER AND VIRAL-ASSOCIATED DISEASE

Authors

Amy B. Hont, Center for Cancer and Immunology Research, Children's National Hospital, Washington DC, USA.
Allison B. Powell, Center for Cancer and Immunology Research, Children's National Hospital, Washington DC, USA.
Danielle K. Sohai, Center for Cancer and Immunology Research, Children's National Hospital, Washington DC, USA.
Izabella K. Valdez, GW Cancer Center, George Washington University, Washington DC, USA.
Maja Stanojevic, Georgetown University Medical Center, Washington DC, USA.
Ashley E. Geiger, Center for Cancer and Immunology Research, Children's National Hospital, Washington DC, USA.
Kajal Chaudhary, Center for Cancer and Immunology Research, Children's National Hospital, Washington DC, USA.
Ehsan K. Dowlati, Georgetown University Medical Center, Washington DC, USA.
Catherine M. Bollard, Center for Cancer and Immunology Research, Children's National Hospital, Washington DC, USA.
Conrad Russell Cruz, Center for Cancer and Immunology Research, Children's National Hospital, Washington DC, USA. Electronic address: ccruz@childrensnational.org.

Document Type

Journal Article

Publication Date

2-8-2022

Journal

Molecular therapy : the journal of the American Society of Gene Therapy

DOI

10.1016/j.ymthe.2022.02.002

Keywords

Antigen-specific T cells; adoptive immunotherapy; cancer; manufacturing protocols; virus infection

Abstract

Immunotherapy with antigen-specific T cells is a promising, targeted therapeutic option for patients with cancer as well as for immunocompromised patients with virus infections. In this review, we characterize and compare current manufacturing protocols for the generation of T cells specific to viral and non-viral tumor associated antigens. Specifically, we discuss: (i) the different methodologies to expand virus-specific T cell (VST) and non-viral tumor-associated antigen specific T cell (TAA-T) products, (ii) the immunological principles involved when developing such manufacturing protocols and (iii) proposed standardized methodologies for the generation of polyclonal, polyfunctional antigen-specific T cells irrespective of donor source. Ex vivo-expanded cells have been safely administered to treat numerous patients with virus-associated malignancies, hematologic malignancies, and solid tumors. Hence, we have performed a comprehensive review of the clinical trial results evaluating the safety, feasibility, and efficacy of these products in the clinic. In summary, this review seeks to provide new insights regarding antigen-specific T cell technology to benefit a rapidly expanding T cell therapy field.

APA Citation

Hont, Amy B.; Powell, Allison B.; Sohai, Danielle K.; Valdez, Izabella K.; Stanojevic, Maja; Geiger, Ashley E.; Chaudhary, Kajal; Dowlati, Ehsan K.; Bollard, Catherine M.; and Cruz, Conrad Russell, "THE GENERATION AND APPLICATION OF ANTIGEN-SPECIFIC T CELL THERAPIES FOR CANCER AND VIRAL-ASSOCIATED DISEASE" (2022). GW Authored Works. Paper 316.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/316

Department

Microbiology, Immunology, and Tropical Medicine