The tumor microenvironment and immune targeting therapy in pediatric renal tumors

Authors

Amy B. Hont, Department of Hematology/Oncology, Children's National Hospital, George Washington University, Washington, District of Columbia, USA.
Benoit Dumont, Pediatric Hematology and Oncology Institute, Léon Bérard Cancer Center, Lyon, France.
Kathryn S. Sutton, Department of Pediatrics, Children's Healthcare of Atlanta, Emory University, Atlanta, Georgia, USA.
John Anderson, Developmental Biology and Cancer Programme, UCL Great Ormond Street Institute of Child Health, London, UK.
Alex Kentsis, Tow Center for Developmental Oncology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center and Weill Medical College of Cornell University, New York, New York, USA.
Jarno Drost, Princess Máxima Center and Oncode Institute, Utrecht, The Netherlands.
Andrew L. Hong, Department of Pediatrics, Children's Healthcare of Atlanta, Emory University, Atlanta, Georgia, USA.
Arnauld Verschuur, Department of Pediatric Hematology and Oncology, Hôpital d'Enfants de la Timone, APHM, Marseille, France.

Document Type

Journal Article

Publication Date

11-30-2022

Journal

Pediatric blood & cancer

DOI

10.1002/pbc.30110

Keywords

immunotherapy; pediatric renal tumor; tumor microenvironment

Abstract

This review highlights the role of several immunomodulating elements contributing to the tumor microenvironment of various pediatric renal tumors including Wilms tumor. The roles of innate and adaptive immune cells in renal tumors are summarized as well as immunomodulatory cytokines and other proteins. The expression and the predictive role of checkpoint modulators like PD-L1 and immunomodulating proteins like glypican-3, B7-H3, COX-2 are highlighted with a translational view toward potential therapeutic innovations. We further discuss the current state of preclinical models in advancing this field of study. Finally, examples of clinical trials of immunomodulating strategies such as monoclonal antibodies and chimeric antigen receptor T (CAR-T) cells for relapsed/refractory/progressive pediatric renal tumors are described.

APA Citation

Hont, Amy B.; Dumont, Benoit; Sutton, Kathryn S.; Anderson, John; Kentsis, Alex; Drost, Jarno; Hong, Andrew L.; and Verschuur, Arnauld, "The tumor microenvironment and immune targeting therapy in pediatric renal tumors" (2022). GW Authored Works. Paper 1876.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/1876

Department

Pediatrics