Racial and Ethnic Differences in Sociodemographic, Clinical, and Treatment Characteristics Among Patients with Atopic Dermatitis in the United States and Canada: Real-World Data from the CorEvitas Atopic Dermatitis Registry

Authors

Jonathan I. Silverberg, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Vivian Y. Shi, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Andrew Alexis, Weill Cornell Medicine, New York, NY, USA.
Evangeline Pierce, Eli Lilly and Company, 893 S. Delaware Street, Indianapolis, IN, 46225, USA. evangeline.pierce@lilly.com.
Angel Cronin, CorEvitas LLC, Waltham, MA, USA.
Robert R. McLean, CorEvitas LLC, Waltham, MA, USA.
Carla Roberts-Toler, CorEvitas LLC, Waltham, MA, USA.
Maria J. Rueda, Eli Lilly and Company, 893 S. Delaware Street, Indianapolis, IN, 46225, USA.
Amber R. Atwater, Eli Lilly and Company, 893 S. Delaware Street, Indianapolis, IN, 46225, USA.
Eric Simpson, Oregon Health and Science University, Portland, OR, USA.

Document Type

Journal Article

Publication Date

7-22-2023

Journal

Dermatology and therapy

DOI

10.1007/s13555-023-00980-6

Keywords

Atopic dermatitis; Ethnic; Patient-reported outcomes; Patterns; Racial; Sociodemographic

Abstract

INTRODUCTION: This real-world, cross-sectional study compared sociodemographic, clinical and treatment characteristics, and patient-reported outcomes (PROs) among racial/ethnic groups in patients with atopic dermatitis (AD) who are candidates for systemic therapy. METHODS: This study included adults with dermatologist- or dermatology practitioner-diagnosed AD enrolled in the CorEvitas AD Registry (July 2020-July 2021). All patients initiated systemic therapy within 12 months prior to or at enrollment or had moderate-to-severe AD (vIGA-AD ≥ 3 and Eczema Area and Severity Index [EASI] ≥ 12) at enrollment. Patients were categorized into five mutually exclusive racial/ethnic groups: non-Hispanic White, Black, Asian, Other/Multiracial, and Hispanic (any race). Patient, clinical, and treatment characteristics were captured at enrollment. Differences in means or proportions of characteristics among racial/ethnic groups were descriptively summarized using effect sizes. Adjusted prevalence ratios and mean differences were estimated (White race/ethnicity group as the reference category) with 95% confidence intervals (CI). RESULTS: Among 1288 patients, 64% (n = 822) were White, 13% (n = 167) Black, 10% (n = 129) Asian, 8% (n = 97) Hispanic, and 6% (n = 73) Other/Multiracial. In adjusted analyses, statistically more severe EASI lichenification was noted among Black compared with White patients at the head and neck (mean difference, 0.21, [95% CI 0.06, 0.36]; p = 0.01), trunk (0.32, [0.17, 0.47]; p < 0.001), upper extremities (0.27, [0.09, 0.44]; p = 0.008), and lower extremities (0.39, [0.21, 0.57]; p < 0.001). Statistically more severe EASI lichenification was observed among Asian vs White patients in certain areas (mean difference, head and neck, 0.22 [0.04, 0.39], p = 0.01; trunk, 0.25 [0.07, 0.43], p < 0.001; lower extremities, 0.22 [0.01, 0.43], p < 0.001) and SCORing for AD lichenification (mean difference: 0.34 [0.15, 0.52]; p < 0.001). Significantly higher mean pruritus over the past 7 days for Black (mean difference: 0.63 [0.01, 1.26] and Hispanic patients (0.60 [0.11, 1.09]; p = 0.03) vs White patients was observed. Among AD clinical features, the prevalence of facial erythema was significantly lower among Black compared with White patients (prevalence ratio = 0.38, [0.22, 0.67]; p = 0.007). CONCLUSION: Racial/ethnic differences exist in sociodemographic, clinical and treatment characteristics, disease severity, and PROs among real-world AD patients who are candidates for systemic therapy. Recognizing these variations may be of critical importance for dermatologists for the design and delivery of targeted/personalized medicine approaches.

APA Citation

Silverberg, Jonathan I.; Shi, Vivian Y.; Alexis, Andrew; Pierce, Evangeline; Cronin, Angel; McLean, Robert R.; Roberts-Toler, Carla; Rueda, Maria J.; Atwater, Amber R.; and Simpson, Eric, "Racial and Ethnic Differences in Sociodemographic, Clinical, and Treatment Characteristics Among Patients with Atopic Dermatitis in the United States and Canada: Real-World Data from the CorEvitas Atopic Dermatitis Registry" (2023). GW Authored Works. Paper 3041.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/3041

Department

Dermatology