Prevalence and Burden of Atopic Dermatitis Involving the Head, Neck, Face, and Hand: A Cross Sectional Study from the TARGET-DERM AD Cohort

Authors

Jonathan I. Silverberg, Department of Dermatology, George Washington University, Washington, D.C, USA. Electronic address: Jonathanisilverberg@gmail.com.
Brenda Simpson, El Paso Dermatology, El Paso, T.X, USA.
Katrina Abuabara, Department of Dermatology, University of California, San Francisco, San Francisco, C.A, USA.
Emma Guttman-Yassky, Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, N.Y, USA.
Brian Calimlim, AbbVie Inc, North Chicago, I.L, USA.
Colleen Wegzyn, AbbVie Inc, North Chicago, I.L, USA.
Whitney Krueger, AbbVie Inc, North Chicago, I.L, USA.
Amy Gamelli, AbbVie Inc, North Chicago, I.L, USA.
Breda Munoz, Target RWE Health Evidence Solutions, Durham, N.C, USA.
Rachel W. Faller, Target RWE Health Evidence Solutions, Durham, N.C, USA.
Julie M. Crawford, Target RWE Health Evidence Solutions, Durham, N.C, USA.
Ayman Grada, AbbVie Inc, North Chicago, I.L, USA.
Lawrence F. Eichenfield, Department of Dermatology, University of California, San Diego, La Jolla, C.A, USA.

Document Type

Journal Article

Publication Date

5-5-2023

Journal

Journal of the American Academy of Dermatology

DOI

10.1016/j.jaad.2023.04.052

Keywords

Atopic Dermatitis (AD); Body Surface Area (BSA); Burden; Burden of Disease; Children’s Dermatology Life Quality Index (CDLQI); Dermatology Life Quality Index (DLQI); Face; Hands; Head; Neck; PO-SCORAD; Patient Reported Outcomes Measurement Information System (PROMIS); Patient-Oriented Eczema Measure (POEM); Prevalence; Quality of Life (QoL); adult; challenging; child; difficult; disease; longitudinal; observational; patient reported outcome (PRO); pediatric; real-world; severe; treatment; vIGA-AD TARGET-DERM; visible

Abstract

BACKGROUND: AD is severely burdensome, and there has been poor characterization of any differences in impact based on the area affected. OBJECTIVE: To estimate the prevalence and HRQoL impact of Head/Face/Neck/Hand (HFNH) involvement among patients with moderate-to-severe AD. METHODS: All TARGET-DERM AD registry patients with moderate/severe Investigator Global Assessment (vIGA-AD) were assessed using the Patient Oriented SCORing Atopic Dermatitis, Patient Oriented Eczema Measure (POEM) and the (Children's) Dermatology Life Quality Index ((C)DLQI). RESULTS: 541 participants met criteria (75.0% adults) and 84% (N=453) reported HFNH involvement. HFNH and non-HFNH involved participants had similar characteristics; 55.2% female and 46.9% White. Compared to the non-HFNH involved, the involved had severe vIGA-AD (28.5% vs. 16.3%, p=0.02) and higher median body surface area affected (15% vs. 10%, p≤0.01) and were twice as likely to have higher (C)DLQI and POEM scores. LIMITATIONS: This was an analysis of real-world and patient reported outcome data. CONCLUSION: Real-world HFNH involved AD patients were associated with significantly worse quality of life, POEM/(C)DLQI, and more severe disease. Detailed assessments of specific areas affected by AD are needed to personalize treatment.

APA Citation

Silverberg, Jonathan I.; Simpson, Brenda; Abuabara, Katrina; Guttman-Yassky, Emma; Calimlim, Brian; Wegzyn, Colleen; Krueger, Whitney; Gamelli, Amy; Munoz, Breda; Faller, Rachel W.; Crawford, Julie M.; Grada, Ayman; and Eichenfield, Lawrence F., "Prevalence and Burden of Atopic Dermatitis Involving the Head, Neck, Face, and Hand: A Cross Sectional Study from the TARGET-DERM AD Cohort" (2023). GW Authored Works. Paper 2939.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/2939

Department

Dermatology