Immunoglobulin E-virus phenotypes of infant bronchiolitis and risk of childhood asthma

Authors

Ryohei Shibata, Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Zhaozhong Zhu, Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Tadao Ooka, Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Robert J. Freishtat, Center for Genetic Medicine Research, Children's National Research Institute, Washington, DC, United States.
Jonathan M. Mansbach, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.
Marcos Pérez-Losada, Department of Biostatistics and Bioinformatics, Computational Biology Institute, The George Washington University, Washington, DC, United States.
Ignacio Ramos-Tapia, Microbial Data Science Laboratory, Center for Bioinformatics and Integrative Biology, Universidad Andres Bello, Santiago, Chile.
Stephen Teach, Division of Emergency Medicine, Children's National Hospital, Washington, DC, United States.
Carlos A. Camargo, Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Kohei Hasegawa, Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.

Document Type

Journal Article

Publication Date

1-1-2023

Journal

Frontiers in immunology

Volume

14

DOI

10.3389/fimmu.2023.1187065

Keywords

RSV (respiratory syncytial virus); asthma; bronchiolitis; immunoglobulin E; mRNA; microRNA; phenotyping; rhinovirus (RV)

Abstract

BACKGROUND: Bronchiolitis is the leading cause of infant hospitalization in U.S. and is associated with increased risk for childhood asthma. Immunoglobulin E (IgE) not only plays major roles in antiviral immune responses and atopic predisposition, but also offers a potential therapeutic target. OBJECTIVE: We aimed to identify phenotypes of infant bronchiolitis by using total IgE (tIgE) and virus data, to determine their association with asthma development, and examine their biological characteristics. METHODS: In a multicenter prospective cohort study of 1,016 infants (age <1 year) hospitalized for bronchiolitis, we applied clustering approaches to identify phenotypes by integrating tIgE and virus (respiratory syncytial virus [RSV], rhinovirus [RV]) data at hospitalization. We examined their longitudinal association with the risk of developing asthma by age 6 years and investigated their biological characteristics by integrating the upper airway mRNA and microRNA data in a subset (n=182). RESULTS: In infants hospitalized for bronchiolitis, we identified 4 phenotypes: 1) tIgEvirus, 2) tIgEvirus, 3) tIgEvirus, and 4) tIgEvirus phenotypes. Compared to phenotype 1 infants (resembling "classic" bronchiolitis), phenotype 4 infants (tIgEvirus) had a significantly higher risk for developing asthma (19% vs. 43%; adjOR, 2.93; 95% CI, 1.02-8.43; =.046). Phenotypes 3 and 4 (tIgE) had depleted type I interferon and enriched antigen presentation pathways; phenotype 4 also had depleted airway epithelium structure pathways. CONCLUSIONS: In this multicenter cohort, tIgE-virus clustering identified distinct phenotypes of infant bronchiolitis with differential risks of asthma development and unique biological characteristics.

APA Citation

Shibata, Ryohei; Zhu, Zhaozhong; Ooka, Tadao; Freishtat, Robert J.; Mansbach, Jonathan M.; Pérez-Losada, Marcos; Ramos-Tapia, Ignacio; Teach, Stephen; Camargo, Carlos A.; and Hasegawa, Kohei, "Immunoglobulin E-virus phenotypes of infant bronchiolitis and risk of childhood asthma" (2023). GW Authored Works. Paper 2924.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/2924

Department

Pediatrics