Diversity of cells and signals in the cardiovascular system

Eleonora Grandi, Department of Pharmacology, University of California Davis, Davis, CA, USA.
Manuel F. Navedo, Department of Pharmacology, University of California Davis, Davis, CA, USA.
Jeffrey J. Saucerman, Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA.
Donald M. Bers, Department of Pharmacology, University of California Davis, Davis, CA, USA.
Nipavan Chiamvimonvat, Department of Pharmacology, University of California Davis, Davis, CA, USA.
Rose E. Dixon, Department of Physiology and Membrane Biology, University of California Davis, Davis, CA, USA.
Dobromir Dobrev, Institute of Pharmacology, West German Heart and Vascular Center, University Duisburg-Essen, Essen, Germany.
Ana M. Gomez, Signaling and Cardiovascular Pathophysiology-UMR-S 1180, INSERM, Université Paris-Saclay, Orsay, France.
Osama F. Harraz, Department of Pharmacology, Larner College of Medicine, and Vermont Center for Cardiovascular and Brain Health, University of Vermont, Burlington, VT, USA.
Bence Hegyi, Department of Pharmacology, University of California Davis, Davis, CA, USA.
David K. Jones, Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, USA.
Trine Krogh-Madsen, Department of Physiology & Biophysics, Weill Cornell Medicine, New York, NY, USA.
Walter Lee Murfee, J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA.
Matthew A. Nystoriak, Department of Medicine, Division of Environmental Medicine, Center for Cardiometabolic Science, University of Louisville, Louisville, KY, USA.
Nikki G. Posnack, Department of Pediatrics, Department of Pharmacology and Physiology, The George Washington University, Washington, DC, USA.
Crystal M. Ripplinger, Department of Pharmacology, University of California Davis, Davis, CA, USA.
Rengasayee Veeraraghavan, Department of Biomedical Engineering, The Ohio State University, Columbus, OH, USA.
Seth Weinberg, Department of Biomedical Engineering, The Ohio State University, Columbus, OH, USA.

Document Type

Journal Article

Publication Date

2-6-2023

Journal

The Journal of physiology

DOI

10.1113/JP284011

Keywords

animal models; ion channels; ion transporters; modelling; omics; signal transduction

Abstract

This white paper is the outcome of the seventh UC Davis Cardiovascular Research Symposium on Systems Approach to Understanding Cardiovascular Disease and Arrhythmia. This biannual meeting aims to bring together leading experts in subfields of cardiovascular biomedicine to focus on topics of importance to the field. The theme of the 2022 Symposium was 'Cell Diversity in the Cardiovascular System, cell-autonomous and cell-cell signalling'. Experts in the field contributed their experimental and mathematical modelling perspectives and discussed emerging questions, controversies, and challenges in examining cell and signal diversity, co-ordination and interrelationships involved in cardiovascular function. This paper originates from the topics of formal presentations and informal discussions from the Symposium, which aimed to develop a holistic view of how the multiple cell types in the cardiovascular system integrate to influence cardiovascular function, disease progression and therapeutic strategies. The first section describes the major cell types (e.g. cardiomyocytes, vascular smooth muscle and endothelial cells, fibroblasts, neurons, immune cells, etc.) and the signals involved in cardiovascular function. The second section emphasizes the complexity at the subcellular, cellular and system levels in the context of cardiovascular development, ageing and disease. Finally, the third section surveys the technological innovations that allow the interrogation of this diversity and advancing our understanding of the integrated cardiovascular function and dysfunction.

Department

Pediatrics

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