How Traumatic Brain Injury History Relates to Brain Health MRI Markers and Dementia Risk: Findings from the 3C Dijon Cohort

Authors

Leslie Grasset, University of Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219; CIC1401-EC, Bordeaux, France.
Melinda C. Power, Department of Epidemiology, Milken Institute School of Public Health, George Washington University, Washington, DC, USA.
Fabrice Crivello, University of Bordeaux, CNRS, IMN, UMR 5293, Bordeaux, France.
Christophe Tzourio, University of Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219; Bordeaux, France.
Geneviève Chêne, University of Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219; CIC1401-EC, Bordeaux, France.
Carole Dufouil, University of Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219; CIC1401-EC, Bordeaux, France.

Document Type

Journal Article

Publication Date

1-23-2023

Journal

Journal of Alzheimer's disease : JAD

DOI

10.3233/JAD-220658

Keywords

Alzheimer’s disease; brain MRI; dementia; traumatic brain injury

Abstract

BACKGROUND: The long-term effects of traumatic brain injury (TBI) with loss of consciousness (LOC) on magnetic resonance imaging (MRI) markers of brain health and on dementia risk are still debated. OBJECTIVE: To investigate the associations of history of TBI with LOC with incident dementia and neuroimaging markers of brain structure and small vessel disease lesions. METHODS: The analytical sample consisted in 4,144 participants aged 65 and older who were dementia-free at baseline from the Three City -Dijon study. History of TBI with LOC was self-reported at baseline. Clinical Dementia was assessed every two to three years, up to 12 years of follow-up. A subsample of 1,675 participants <80 years old underwent a brain MRI at baseline. We investigated the associations between history of TBI with LOC and 1) incident all cause and Alzheimer's disease (AD) dementia using illness-death models, and 2) neuroimaging markers at baseline. RESULTS: At baseline, 8.3% of the participants reported a history of TBI with LOC. In fully-adjusted models, participants with a history of TBI with LOC had no statistically significant differences in dementia risk (HR = 0.90, 95% CI = 0.60-1.36) or AD risk (HR = 1.03, 95% CI = 0.69-1.52), compared to participants without TBI history. History of TBI with LOC was associated with lower white matter volume (β= -4.58, p = 0.048), but not with other brain volumes, white matter hyperintensities volume, nor covert brain infarct. CONCLUSION: This study did not find evidence of an association between history of TBI with LOC and dementia or AD dementia risks over 12-year follow-up, brain atrophy, or markers of small vessel disease.

APA Citation

Grasset, Leslie; Power, Melinda C.; Crivello, Fabrice; Tzourio, Christophe; Chêne, Geneviève; and Dufouil, Carole, "How Traumatic Brain Injury History Relates to Brain Health MRI Markers and Dementia Risk: Findings from the 3C Dijon Cohort" (2023). GW Authored Works. Paper 2247.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/2247

Department

Epidemiology