Interval Time of at Least 6 Weeks Between Bilateral Total Knee Arthroplasties is Associated with Decreased Postoperative Complications

Authors

Amil R. Agarwal, Department of Orthopaedic Surgery, George Washington University Hospital, 2300 M St NW, Washington DC, 20037; Department of Orthopaedic Surgery, Adult Reconstruction Division, Johns Hopkins University, 10700 Charter Drive, Suite 205, Columbia, MD 21044. Electronic address: amil_agarwal@gwu.edu.
Alex Gu, Department of Orthopaedic Surgery, George Washington University Hospital, 2300 M St NW, Washington DC, 20037.
Kevin Y. Wang, Department of Orthopaedic Surgery, Adult Reconstruction Division, Johns Hopkins University, 10700 Charter Drive, Suite 205, Columbia, MD 21044.
Andrew B. Harris, Department of Orthopaedic Surgery, Adult Reconstruction Division, Johns Hopkins University, 10700 Charter Drive, Suite 205, Columbia, MD 21044.
Joshua Campbell, Department of Orthopaedic Surgery, George Washington University Hospital, 2300 M St NW, Washington DC, 20037.
Savyasachi C. Thakkar, Department of Orthopaedic Surgery, Adult Reconstruction Division, Johns Hopkins University, 10700 Charter Drive, Suite 205, Columbia, MD 21044.
Gregory J. Golladay, Department of Orthopedic Surgery, Virginal Commonwealth University Medical Center Orthopaedics, 417 N 11(th) St, Richmond, VA 23298.

Document Type

Journal Article

Publication Date

12-22-2022

Journal

The Journal of arthroplasty

DOI

10.1016/j.arth.2022.12.037

Keywords

Knee Arthroscopy; Knee Replacement; Revision; Total Knee Arthroplasty

Abstract

BACKGROUND: Staged, bilateral total knee arthroplasty (TKA) has an increased risk of complications if the second procedure is performed before physiologic recovery from the first. The aims of this study were to 1) determine whether there is a time-dependent relationship between TKA staging and rates of revisions and complications and 2) identify data-driven time intervals that reduce risk of revisions and complications. METHODS: Data was collected from a national insurance database from 2015 to 2018. Staged intervals were initially assessed using fixed 6-week intervals. Stratum specific likelihood ratio (SSLR) analyses were subsequently conducted to observe data-driven staging thresholds. Bivariate and multivariable regression analyses were conducted to determine the associations between the time intervals and 2-year rates of revision surgery and 90-day major complications. We included 25,527 patients undergoing staged bilateral TKA. RESULTS: In comparison to the shortest fixed time interval (1-6 weeks), as the staging interval increased the odds of 2-year all-cause revision and 90-day major complications significantly decreased (p<0.05 for all). SSLR analysis identified three data-driven staging categories 1-5, 6-17, and 18-24 weeks that maximized the difference in both 2-year rates of revision and 90-day major complications. CONCLUSIONS: Our data showed a time-dependent relationship between the timing of TKA stages and complications. If staging is considered, a delayed interval of at least 6 weeks between procedures may significantly reduce revision and major complications.

APA Citation

Agarwal, Amil R.; Gu, Alex; Wang, Kevin Y.; Harris, Andrew B.; Campbell, Joshua; Thakkar, Savyasachi C.; and Golladay, Gregory J., "Interval Time of at Least 6 Weeks Between Bilateral Total Knee Arthroplasties is Associated with Decreased Postoperative Complications" (2022). GW Authored Works. Paper 2062.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/2062

Department

School of Medicine and Health Sciences Resident Works