Breakthrough SARS-CoV-2 Infections after Vaccination in North Carolina
Ad26.COV2.S; BNT162b2; Delta; Omicron; SARS-CoV-2 vaccination; age; booster vaccination; cumulative incidence; mRNA-1273; rural county
We characterize the overall incidence and risk factors for breakthrough infection among fully vaccinated participants in the North Carolina COVID-19 Community Research Partnership cohort. Among 15,808 eligible participants, 638 reported a positive SARS-CoV-2 test after vaccination. Factors associated with a lower risk of breakthrough in the time-to-event analysis included older age, prior SARS-CovV-2 infection, higher rates of face mask use, and receipt of a booster vaccination. Higher rates of breakthrough were reported by participants vaccinated with BNT162b2 or Ad26.COV2.S compared to mRNA-1273, in suburban or rural counties compared to urban counties, and during circulation of the Delta and Omicron variants.
Uschner, Diane; Bott, Matthew; Lagarde, William H.; Keating, Joseph; Tapp, Hazel; Berry, Andrea A.; Seals, Austin L.; Munawar, Iqra; Schieffelin, John; Yukich, Joshua; Santacatterina, Michele; Gunaratne, Mihili; Fette, Lida M.; Burke, Brian; Strylewicz, Greg; Edelstein, Sharon L.; Ahmed, Amina; Miller, Kristen; Sanders, John W.; Herrington, David; Weintraub, William S.; Runyon, Michael S.; and On Behalf Of The Covid-Community Research Partnership, "Breakthrough SARS-CoV-2 Infections after Vaccination in North Carolina" (2022). GW Authored Works. Paper 1940.
Biostatistics and Bioinformatics