Breakthrough SARS-CoV-2 Infections after Vaccination in North Carolina

Authors

• Diane Uschner, The Biostatistics Center, George Washington University, Rockville, MD 20852, USA.
• Matthew Bott, The Biostatistics Center, George Washington University, Rockville, MD 20852, USA.
• William H. Lagarde, Division of Pediatric Endocrinology, Department of Pediatrics, WakeMed Health and Hospitals, Raleigh, NC 27610, USA.
• Joseph Keating, Department of Tropical Medicine, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70118, USA.
• Hazel Tapp, Department of Family Medicine, Atrium Health Carolinas Medical Center, Charlotte, NC 28262, USA.
• Andrea A. Berry, Department of Pediatrics, Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
• Austin L. Seals, Division of Cardiology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27109, USA.
• Iqra Munawar, Division of Infectious Diseases, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27109, USA.
• John Schieffelin, Section of Infectious Disease, Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA.
• Joshua Yukich, Department of Tropical Medicine, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70118, USA.
• Michele Santacatterina, The Biostatistics Center, George Washington University, Rockville, MD 20852, USA.
• Mihili Gunaratne, The Biostatistics Center, George Washington University, Rockville, MD 20852, USA.
• Lida M. Fette, The Biostatistics Center, George Washington University, Rockville, MD 20852, USA.
• Brian Burke, The Biostatistics Center, George Washington University, Rockville, MD 20852, USA.
• Greg Strylewicz, The Biostatistics Center, George Washington University, Rockville, MD 20852, USA.
• Sharon L. Edelstein, The Biostatistics Center, George Washington University, Rockville, MD 20852, USA.
• Amina Ahmed, Department of Pediatrics, Atrium Health Levine Children's Hospital, Charlotte, NC 28203, USA.
• Kristen Miller, MedStar Health Research Institute, Georgetown University, Washington, DC 20007, USA.
• John W. Sanders, Division of Infectious Diseases, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27109, USA.
• David Herrington, Division of Cardiology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27109, USA.
• William S. Weintraub, MedStar Health Research Institute, Georgetown University, Washington, DC 20007, USA.
• Michael S. Runyon, Department of Emergency Medicine, Atrium Health Carolinas Medical Center, Charlotte, NC 28262, USA.
• On Behalf Of The Covid-Community Research Partnership

Document Type

Journal Article

Publication Date

11-13-2022

Journal

Vaccines

Volume

10

Issue

11

DOI

10.3390/vaccines10111922

Keywords

Ad26.COV2.S; BNT162b2; Delta; Omicron; SARS-CoV-2 vaccination; age; booster vaccination; cumulative incidence; mRNA-1273; rural county

Abstract

We characterize the overall incidence and risk factors for breakthrough infection among fully vaccinated participants in the North Carolina COVID-19 Community Research Partnership cohort. Among 15,808 eligible participants, 638 reported a positive SARS-CoV-2 test after vaccination. Factors associated with a lower risk of breakthrough in the time-to-event analysis included older age, prior SARS-CovV-2 infection, higher rates of face mask use, and receipt of a booster vaccination. Higher rates of breakthrough were reported by participants vaccinated with BNT162b2 or Ad26.COV2.S compared to mRNA-1273, in suburban or rural counties compared to urban counties, and during circulation of the Delta and Omicron variants.

APA Citation

Uschner, Diane; Bott, Matthew; Lagarde, William H.; Keating, Joseph; Tapp, Hazel; Berry, Andrea A.; Seals, Austin L.; Munawar, Iqra; Schieffelin, John; Yukich, Joshua; Santacatterina, Michele; Gunaratne, Mihili; Fette, Lida M.; Burke, Brian; Strylewicz, Greg; Edelstein, Sharon L.; Ahmed, Amina; Miller, Kristen; Sanders, John W.; Herrington, David; Weintraub, William S.; Runyon, Michael S.; and On Behalf Of The Covid-Community Research Partnership, "Breakthrough SARS-CoV-2 Infections after Vaccination in North Carolina" (2022). GW Authored Works. Paper 1940.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/1940

Department

Biostatistics and Bioinformatics