Milken Institute School of Public Health Poster Presentations (Marvin Center & Video)

Poster Number

1A

Document Type

Poster

Status

Graduate Student - Masters

Abstract Category

Environmental and Occupational Health

Keywords

Triclosan; prostate; benzophenone-3; bisphenol A

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Publication Date

4-2017

Abstract

Background: Exposure to environmental phenols (e.g., bisphenol A, benzophenone-3, and triclosan) is widespread in the population. Many of these chemicals have been shown to have adverse effects on reproductive organs and hormones, both in vitro and in vivo.

Objective: This study aimed to (1) provide descriptive information about prostate specific antigen levels and (2) examine the association of bisphenol A (BPA), benzophenone-3 (BP-3), and triclosan (TCS) with serum prostate specific antigen (PSA) levels in male participants (ages 40+ years) in the National Health and Nutrition Examination Survey (NHANES) 2005-2010.

Methods: Geometric and weighted means, chi-square tests, and logistic regressions were used to provide descriptive information about PSA distribution in these male participants. Multivariable logistic regression was used to estimate associations between serum PSA level risk classification for prostate cancer (high and low) and levels of log-transformed and creatinine adjusted urinary BPA, BP-3, and TCS, in male participants.

(Preliminary) Results: BP-3 was associated with significantly higher likelihood of higher prostate specific antigen levels and prostatic cancer in males.

(Preliminary) Conclusions: To the researcher's knowledge, this is the first study to produce a report on the distribution of PSA in the USA from NHANES. It also is novel in its report of an association of BP-3 with serum PSA in males. However, because of the limitations inherent to the cross-sectional study design, further studies are needed to confirm and elucidate on our findings.

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

Open Access

1

Comments

Poster to be presented at GW Annual Research Days 2017.

This poster is the winner of the Judges Choice Award: Video Submission.

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(VIDEO) Household Chemicals and Prostate Health: Serum Prostate Specific Antigen Levels and Urinary Benzophenone-3, Bisphenol A, and Triclosan Levels in Males: NHANES 2005-2010

Background: Exposure to environmental phenols (e.g., bisphenol A, benzophenone-3, and triclosan) is widespread in the population. Many of these chemicals have been shown to have adverse effects on reproductive organs and hormones, both in vitro and in vivo.

Objective: This study aimed to (1) provide descriptive information about prostate specific antigen levels and (2) examine the association of bisphenol A (BPA), benzophenone-3 (BP-3), and triclosan (TCS) with serum prostate specific antigen (PSA) levels in male participants (ages 40+ years) in the National Health and Nutrition Examination Survey (NHANES) 2005-2010.

Methods: Geometric and weighted means, chi-square tests, and logistic regressions were used to provide descriptive information about PSA distribution in these male participants. Multivariable logistic regression was used to estimate associations between serum PSA level risk classification for prostate cancer (high and low) and levels of log-transformed and creatinine adjusted urinary BPA, BP-3, and TCS, in male participants.

(Preliminary) Results: BP-3 was associated with significantly higher likelihood of higher prostate specific antigen levels and prostatic cancer in males.

(Preliminary) Conclusions: To the researcher's knowledge, this is the first study to produce a report on the distribution of PSA in the USA from NHANES. It also is novel in its report of an association of BP-3 with serum PSA in males. However, because of the limitations inherent to the cross-sectional study design, further studies are needed to confirm and elucidate on our findings.

 

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