Milken Institute School of Public Health Poster Presentations (Marvin Center & Video)

Poster Number

1C

Document Type

Poster

Status

Graduate Student - Masters

Abstract Category

Prevention and Community Health

Keywords

perinatal hepatitis B; post-vaccination serological test; PVST; hepatitis B; Houston

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Publication Date

4-2017

Abstract

Purpose: Hepatitis B virus (HBV) is a serious bloodborne viral infection and can lead to premature death from hepatocellular carcinoma. Pregnant women with chronic HBV pose a serious threat to their infants; hence, post-exposure immunoprohylaxis is necessary. Post-Vaccination Serological Testing (PVST) is also recommended to test an infant's immune response to the HBV vaccinations. The Perinatal Hepatitis B Prevention Program (PBHPP) aims to prevent transmission of HBV from infected mothers to babies born in the United States. Although, the majority of cases can be traced to the Western Pacific and African regions, there is limited knowledge on factors that affect PVST completion among cases managed by the Houston Health Department (HHD). This project aims to assess the PVST completion rates among infants born between January 1, 2015 to December 31, 2015 to HBV-positive mothers managed by HHD.

Methods: Infants born in 2015 to hepatitis B-infected women living in Houston/Harris County, and case-managed by Houston PHBPP were exported from the HHD surveillance system. Maternal race/ethnicity was analyzed for infants who were immune to understand if it influenced PVST completion.

Results: In accordance to the Centers of Disease Control recommendations, infants born to HBV infected women should complete PVST between 9-18 months of age. After analysis of the 232 infants case-managed by the program, 64 infants were excluded. Of the 168 infants eligible for PVST, 76% (n=129) have completed PVST; 84.5% (n=109) infants completed PVST within the recommended interval and 15.5% (n=20) completed PVST after 18 months of age. 54.2% (n=70) are Asian/Pacific Islander (API), 29.5% (n=38) are Black Non-Hispanic, 7% (n=9) are White Hispanic, 6.2% (n=8) are White non-Hispanic, and 3.1% (n=4) are of unknown ethnicity. Of the 39 eligible infants who did not complete PVST, 38% (n=15) are API, 33% (n=13) are Black non-Hispanic, 15% (n=6) are White Hispanic, 8% (n=3) are White non-Hispanic, and 5% (n=2) are of unknown race/ethnicity.

Conclusions: Though the Houston PHBPP PVST completion rates are improving, targeted interventions are needed to focus on increasing the PVST completion rates amongst the API and Black, non-Hispanic groups. Further analysis will be conducted on the 39 infants who have unknown immunity, to fully understand the Houston PHBPP program practices and the factors that affect PVST completion among different racial and ethnic groups.

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

Open Access

1

Comments

Poster to be presented at GW Annual Research Days 2017.

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(VIDEO) Assessing PVST completion rates of infants born to hepatitis B-infected mothers

Purpose: Hepatitis B virus (HBV) is a serious bloodborne viral infection and can lead to premature death from hepatocellular carcinoma. Pregnant women with chronic HBV pose a serious threat to their infants; hence, post-exposure immunoprohylaxis is necessary. Post-Vaccination Serological Testing (PVST) is also recommended to test an infant's immune response to the HBV vaccinations. The Perinatal Hepatitis B Prevention Program (PBHPP) aims to prevent transmission of HBV from infected mothers to babies born in the United States. Although, the majority of cases can be traced to the Western Pacific and African regions, there is limited knowledge on factors that affect PVST completion among cases managed by the Houston Health Department (HHD). This project aims to assess the PVST completion rates among infants born between January 1, 2015 to December 31, 2015 to HBV-positive mothers managed by HHD.

Methods: Infants born in 2015 to hepatitis B-infected women living in Houston/Harris County, and case-managed by Houston PHBPP were exported from the HHD surveillance system. Maternal race/ethnicity was analyzed for infants who were immune to understand if it influenced PVST completion.

Results: In accordance to the Centers of Disease Control recommendations, infants born to HBV infected women should complete PVST between 9-18 months of age. After analysis of the 232 infants case-managed by the program, 64 infants were excluded. Of the 168 infants eligible for PVST, 76% (n=129) have completed PVST; 84.5% (n=109) infants completed PVST within the recommended interval and 15.5% (n=20) completed PVST after 18 months of age. 54.2% (n=70) are Asian/Pacific Islander (API), 29.5% (n=38) are Black Non-Hispanic, 7% (n=9) are White Hispanic, 6.2% (n=8) are White non-Hispanic, and 3.1% (n=4) are of unknown ethnicity. Of the 39 eligible infants who did not complete PVST, 38% (n=15) are API, 33% (n=13) are Black non-Hispanic, 15% (n=6) are White Hispanic, 8% (n=3) are White non-Hispanic, and 5% (n=2) are of unknown race/ethnicity.

Conclusions: Though the Houston PHBPP PVST completion rates are improving, targeted interventions are needed to focus on increasing the PVST completion rates amongst the API and Black, non-Hispanic groups. Further analysis will be conducted on the 39 infants who have unknown immunity, to fully understand the Houston PHBPP program practices and the factors that affect PVST completion among different racial and ethnic groups.

 

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