The role of the mosquito in a dengue human infection model

Document Type

Journal Article

Publication Date

6-15-2014

Journal

Journal of Infectious Diseases

Volume

209

Issue

SUPPL. 2

DOI

10.1093/infdis/jiu110

Keywords

allergic response; dengue model; dengue vaccine; dengue virus; humoral immunity; Infection model; innate immunity; mosquito

Abstract

Recent efforts to combat the growing global threat of dengue disease, including deployment of phase IIb vaccine trials, has continued to be hindered by uncertainty surrounding equitable immune responses of serotypes, relative viral fitness of vaccine vs naturally occurring strains, and the importance of altered immune environments due to natural delivery routes. Human infection models can significantly improve our understanding of the importance of certain phenotypic characteristics of viral strains, and inform strain selection and trial design. With human models, we can further assess the importance of the natural delivery route of DENV and/or the accompanying mosquito salivary milieu. Accordingly, we discuss the use of mosquitoes in such a human infection model with DENV, identify important considerations, and make preliminary recommendations for deployment of such a mosquito improved DENV human infection model (miDHIM). © The Author 2014.

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