A new tubulin-binding protein
Document Type
Journal Article
Publication Date
6-15-1982
Journal
Biochemical and Biophysical Research Communications
Volume
106
Issue
3
DOI
10.1016/0006-291X(82)91768-5
Abstract
A new brain protein is described which forms an insoluble complex with tubulin, with concomitant stoichiometric hydrolysis of GTP. The complex contains a maximum of one tubulin-binding protein (MW 52,500) per two tubulin dimers. The tubulin-binding protein (TBP) does not compete with colchicine, but in the presence of microtubule-associated proteins tubulin appeared less accessible to it. Proteins such as TBP might sequester tubulin and thereby function either to inhibit indiscriminate polymerization, or to promote ordered nucleation by maintaining high local concentrations. © 1982.
APA Citation
Kumar, N., & Flavin, M. (1982). A new tubulin-binding protein. Biochemical and Biophysical Research Communications, 106 (3). http://dx.doi.org/10.1016/0006-291X(82)91768-5