Plasmodium falciparum: Detection of a novel asparagine-rich protein on the surface of sporozoite
Document Type
Journal Article
Publication Date
1-1-1999
Journal
Experimental Parasitology
Volume
93
Issue
1
DOI
10.1006/expr.1999.4435
Abstract
We had previously cloned and characterized a gene for a novel asparagine-rich protein from P falciparum (PfARP), a target of natural human immune response. The antibodies to PfARP were localized to the surface of parasitized red blood cells and reacted with intracellular components in all erythrocytic asexual and sexual stages of the parasite. We here describe reactivity of antibodies against this novel PfARP on the surface of mosquito stage sporozoite of P. falciparum by indirect immunofluorescence assay and immunoelectron microscopy, the latter revealing a highly periodic punctate pattern of distribution of PfARP on the surface of sporozoite. These results suggest a possibility that PfARP might represent yet another sporozoite surface protein.
APA Citation
Zhang, K., Fujioka, H., Aikawa, M., & Kumar, N. (1999). Plasmodium falciparum: Detection of a novel asparagine-rich protein on the surface of sporozoite. Experimental Parasitology, 93 (1). http://dx.doi.org/10.1006/expr.1999.4435