Rapid detection of malaria parasites

Authors

A. Feldman, Johns Hopkins University Applied Physics Laboratory
J. Lin, Johns Hopkins University Applied Physics Laboratory
S. Murphy, Johns Hopkins University Applied Physics Laboratory
P. Demirev, Johns Hopkins University Applied Physics Laboratory
D. Sullivan, Johns Hopkins University
P. Scholl, Johns Hopkins University
N. Kumar, Johns Hopkins University

Document Type

Conference Proceeding

Publication Date

3-16-2010

Journal

Johns Hopkins APL Technical Digest (Applied Physics Laboratory)

Volume

28

Issue

3

Abstract

APL and JHU Bloomberg School of Public Health researchers have demonstrated that laser desorption mass spectrometry (LDMS) was a sensitive method for detecting malaria parasites in the blood. The method is based on the detection of heme in hemozoin (Hz), the crystalline substance accumulated within malaria parasites during their intraerythrocytic growth stage. The LDMS test was performed without consumables other than a lancet and a container from blood collection. Blood was diluted in water, deposited onto a metal slide, sir dried, and inserted into the mass spectrometer for analysis. Hz heme was identified from the pattern of heme-molecular-structure-specific peaks.

APA Citation

Feldman, A., Lin, J., Murphy, S., Demirev, P., Sullivan, D., Scholl, P., & Kumar, N. (2010). Rapid detection of malaria parasites. Johns Hopkins APL Technical Digest (Applied Physics Laboratory), 28 (3). Retrieved from https://hsrc.himmelfarb.gwu.edu/sphhs_global_facpubs/1116