Identification of biochemically distinct properties of the small ubiquitin-related modifier (SUMO) conjugation pathway in Plasmodium falciparum
Document Type
Journal Article
Publication Date
9-27-2013
Journal
Journal of Biological Chemistry
Volume
288
Issue
39
DOI
10.1074/jbc.M113.498410
Abstract
Background: The sumoylation pathway is conserved in Plasmodium falciparum. Results: The small ubiquitin-related modifier (SUMO) E1 and E2 enzymes are not functionally interchangable between humans and the malaria parasite, P. falciparum. Conclusion: P. falciparum E1 and E2 interactions have significantly diverged from humans. Significance: Divergent E1 and E2 interaction could be exploited for the design of parasite specific inhibitors. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
APA Citation
Reiter, K., Mukhopadhyay, D., Zhang, H., Boucher, L., Kumar, N., Bosch, J., & Matunis, M. (2013). Identification of biochemically distinct properties of the small ubiquitin-related modifier (SUMO) conjugation pathway in Plasmodium falciparum. Journal of Biological Chemistry, 288 (39). http://dx.doi.org/10.1074/jbc.M113.498410