"Identification of biochemically distinct properties of the small ubiqu" by Katherine Reiter, Debaditya Mukhopadhyay et al.
 

Identification of biochemically distinct properties of the small ubiquitin-related modifier (SUMO) conjugation pathway in Plasmodium falciparum

Document Type

Journal Article

Publication Date

9-27-2013

Journal

Journal of Biological Chemistry

Volume

288

Issue

39

DOI

10.1074/jbc.M113.498410

Abstract

Background: The sumoylation pathway is conserved in Plasmodium falciparum. Results: The small ubiquitin-related modifier (SUMO) E1 and E2 enzymes are not functionally interchangable between humans and the malaria parasite, P. falciparum. Conclusion: P. falciparum E1 and E2 interactions have significantly diverged from humans. Significance: Divergent E1 and E2 interaction could be exploited for the design of parasite specific inhibitors. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

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