The Association of Long-Term Exposure to Particulate Matter Air Pollution with Brain MRI Findings: The ARIC Study.

Authors

Melinda C Power, George Washington UniversityFollow
Archana P Lamichhane
Duanping Liao
Xiaohui Xu
Clifford R Jack
Rebecca F Gottesman
Thomas Mosley
James D Stewart
Jeff D Yanosky
Eric A Whitsel

Document Type

Journal Article

Publication Date

2-16-2018

Journal

Environmental health perspectives

Volume

126

Issue

2

DOI

10.1289/EHP2152

Abstract

BACKGROUND: Increasing evidence links higher particulate matter (PM) air pollution exposure to late-life cognitive impairment. However, few studies have considered associations between direct estimates of long-term past exposures and brain MRI findings indicative of neurodegeneration or cerebrovascular disease.

OBJECTIVE: Our objective was to quantify the association between brain MRI findings and PM exposures approximately 5 to 20 y prior to MRI in the Atherosclerosis Risk in Communities (ARIC) study.

METHODS: ARIC is based in four U.S. sites: Washington County, Maryland; Minneapolis suburbs, Minnesota; Forsyth County, North Carolina; and Jackson, Mississippi. A subset of ARIC participants underwent 3T brain MRI in 2011-2013 (n=1,753). We estimated mean exposures to PM with an aerodynamic diameter less than 10 or 2.5μm (PM

RESULTS: In pooled analyses, higher mean PM

CONCLUSIONS: Long-term past PM exposure in was not associated with markers of cerebrovascular disease. Higher long-term past PM exposures were associated with smaller deep-gray volumes overall, and higher PM

Creative Commons License

This work is free of known copyright restrictions.

APA Citation

Power, M., Lamichhane, A., Liao, D., Xu, X., Jack, C., Gottesman, R., Mosley, T., Stewart, J., Yanosky, J., & Whitsel, E. (2018). The Association of Long-Term Exposure to Particulate Matter Air Pollution with Brain MRI Findings: The ARIC Study.. Environmental health perspectives, 126 (2). http://dx.doi.org/10.1289/EHP2152

Peer Reviewed

1

Open Access

1