Uric acid determination in gestational hypertension

Document Type

Journal Article

Publication Date

1-1-2015

Journal

Reproductive Sciences

Volume

22

Issue

10

DOI

10.1177/1933719115572477

Keywords

gestational hypertension; hyperuricemia; preeclampsia; proteinuria; risk

Abstract

We asked, is uric acid as effective as proteinuria at identifying perinatal risk in high-risk women with gestational hypertension? Uric acid was measured in samples obtained 4.6 weeks predelivery in 259 women with prior preeclampsia from the National Institute of Child Health and Human Development network study of low-dose aspirin to prevent preeclampsia. Participants were grouped according to the presence/absence of gestational hypertension (H), proteinuria (P), and hyperuricemia (U). Adverse perinatal outcomes were not different between H or U and women with normal values (normal blood pressure, urinary protein, and uric acid [NNN]). Preterm birth was greater in hypertension and proteinuria (HP) and hypertension and hyperuricemia (HU) compared to NNN (relative risk [RR] = 2.4, P =.03 and 3.8, P <.01), respectively. In addition, in HU women, delivery was earlier (36.6 ± 3.4 vs 38.4 ± 2.3 weeks, P <.001) and small for gestational age infants

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