Correlates of HIV acquisition in a cohort of black men who have sex with men in the United States: HIV prevention trials network (HPTN) 061

Authors

Beryl A. Koblin, New York Blood Center, New York, NY
Kenneth H. Mayer, Fenway Health and Beth Israel Deaconess Hospital, Boston, MAFollow
Susan H. Eshleman, Johns Hopkins University
Lei Wang, Fred Hutchinson Cancer Research Center, Seattle, WA
Sharon B. Mannheimer, Harlem Hospital Center, New York, NY
Carlos Del Rio, Emory University
Steve Shoptaw, University of California - Los Angeles
Manya Magnus, George Washington University
Susan Buchbinder, San Francisco Department of Public Health
Leo Wilton, Binghamton University
Ting-Yuan Liu, Fred Hutchinson Cancer Research Center, Seattle, WA
Vanessa Cummings, Johns Hopkins University
Estelle Piwowar-Manning, Johns Hopkins University
Sheldon D. Fields, Florida International UniversityFollow
Sam Griffith, FHI 360, Research Triangle Park, NC
Vanessa Elharrar, National Institutes of Health
Darrell Wheeler, Loyola University Chicago

Document Type

Journal Article

Publication Date

7-26-2013

Journal

PLoS ONE

Volume

Volume 8, Issue 7

Inclusive Pages

Article number e70413

Abstract

Background

Black men who have sex with men (MSM) in the United States (US) are affected by HIV at disproportionate rates compared to MSM of other race/ethnicities. Current HIV incidence estimates in this group are needed to appropriately target prevention efforts.

Methods

From July 2009 to October 2010, Black MSM reporting unprotected anal intercourse with a man in the past six months were enrolled and followed for one year in six US cities for a feasibility study of a multi-component intervention to reduce HIV infection. HIV incidence based on HIV seroconversion was calculated as number of events/100 person-years. Multivariate proportional hazards modeling with time-dependent covariates was used to identify correlates of HIV acquisition.

Results

Of 1,553 Black MSM enrolled, 1,164 were HIV-uninfected at baseline and included in follow-up. Overall annual HIV incidence was 3.0% (95% confidence interval (CI): 2.0, 4.4%) and 5.9% among men ≤30 years old (95% CI: 3.6, 9.1%). Men ≤30 years old reported significantly higher levels of sexual risk and were more likely to have a sexually transmitted infection diagnosed during follow-up. Younger men also were more likely to not have a usual place for health care, not have visited a health care provider recently, and to have unmet health care needs. In multivariate analysis, age ≤30 years (hazard ratio (HR): 3.4; 95% CI: 1.4, 8.3) and unprotected receptive anal intercourse with HIV-positive or unknown status partners (HR: 4.1; 95% CI: 1.9, 9.1) were significantly associated with HIV acquisition.

Conclusion

In the largest cohort of prospectively-followed Black MSM in the US, HIV incidence was high, particularly among young men. Targeted, tailored and culturally appropriate HIV prevention strategies incorporating behavioral, social and biomedical based interventions are urgently needed to lower these rates.

Comments

Reproduced with permission ofPLoS ONE

Creative Commons License

This work is licensed under a Creative Commons Attribution 3.0 License.

APA Citation

Koblin, B.A., Mayer, K.H., Eshleman, S.H., Wang, L., Mannheimer, S., et al. (2013) Correlates of HIV Acquisition in a Cohort of Black Men Who Have Sex with Men in the United States: HIV Prevention Trials Network (HPTN) 061. PLoS ONE 8(7): e70413.

Peer Reviewed

1

Open Access

1