Document Type
Journal Article
Publication Date
10-12-2016
Journal
Environmental Health
Volume
15
Issue
1
Inclusive Pages
97
DOI
10.1186/s12940-016-0180-6
Abstract
Aneuploidy, defined as structural and numerical aberrations of chromosomes, continues to draw attention as an informative effect biomarker for carcinogens and male reproductive toxicants. It has been well documented that aneuploidy is a hallmark of cancer. Aneuploidies in oocytes and spermatozoa contribute to infertility, pregnancy loss and a number of congenital abnormalities, and sperm aneuploidy is associated with testicular cancer. It is striking that several carcinogens induce aneuploidy in somatic cells, and also adversely affect the chromosome compliment of germ cells. In this paper we review 1) the contributions of aneuploidy to cancer, infertility, and developmental abnormalities; 2) techniques for assessing aneuploidy in precancerous and malignant lesions and in sperm; and 3) the utility of aneuploidy as a biomarker for integrated chemical assessments of carcinogenicity, and reproductive and developmental toxicity.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
APA Citation
Mandrioli, D., Belpoggi, F., Silbergeld, E., & Perry, M. J. (2016). Aneuploidy: a common and early evidence-based biomarker for carcinogens and reproductive toxicants.. Environmental Health, 15 (1). http://dx.doi.org/10.1186/s12940-016-0180-6
Peer Reviewed
1
Open Access
1
Included in
Environmental Health Commons, Environmental Public Health Commons, Occupational Health and Industrial Hygiene Commons, Toxicology Commons
Comments
Reproduced with permission of BioMed Central Ltd. Environmental Health