Each patient is a research biorepository: informatics-enabled research on surplus clinical specimens via the living BioBank.
Document Type
Journal Article
Publication Date
1-15-2021
Journal
Journal of the American Medical Informatics Association : JAMIA
Volume
28
Issue
1
DOI
10.1093/jamia/ocaa236
Keywords
just-in-time biobanking; phenotyped specimen data; phenotyped specimens; translational research services
Publisher
Hanley & Belfus
Abstract
The ability to analyze human specimens is the pillar of modern-day translational research. To enhance the research availability of relevant clinical specimens, we developed the Living BioBank (LBB) solution, which allows for just-in-time capture and delivery of phenotyped surplus laboratory medicine specimens. The LBB is a system-of-systems integrating research feasibility databases in i2b2, a real-time clinical data warehouse, and an informatics system for institutional research services management (SPARC). LBB delivers deidentified clinical data and laboratory specimens. We further present an extension to our solution, the Living µBiome Bank, that allows the user to request and receive phenotyped specimen microbiome data. We discuss the details of the implementation of the LBB system and the necessary regulatory oversight for this solution. The conducted institutional focus group of translational investigators indicates an overall positive sentiment towards potential scientific results generated with the use of LBB. Reference implementation of LBB is available at https://LivingBioBank.musc.edu.
Recommended Citation
Alekseyenko, A., Hamidi, B., Faith, T., Crandall, K. A., Powers, J., Metts, C., Madory, J., Carroll, S., Obeid, J., & Lenert, L. (2021). Each patient is a research biorepository: informatics-enabled research on surplus clinical specimens via the living BioBank.. Journal of the American Medical Informatics Association : JAMIA, 28 (1). http://dx.doi.org/10.1093/jamia/ocaa236
Peer Reviewed
1
Comments
This is an open access PubMed Central article.