Controversies and challenges in research on urogenital schistosomiasis-associated bladder cancer

Document Type

Journal Article

Publication Date

1-1-2014

Journal

Trends in Parasitology

Volume

30

Issue

7

DOI

10.1016/j.pt.2014.05.004

Keywords

Bladder cancer; Schistosoma haematobium; Schistosomiasis haematobia; Urinary schistosomiasis; Urogenital schistosomiasis

Abstract

Urogenital schistosomiasis, infection with Schistosoma haematobium, is linked to increased risk for the development of bladder cancer, but the importance of various mechanisms responsible for this association remains unclear, in part, owing to lack of sufficient and appropriate animal models. New advances in the study of this parasite, bladder regenerative processes, and human schistosomal bladder cancers may shed new light on the complex biological processes that connect S. haematobium infection to bladder carcinogenesis. © 2014 Elsevier Ltd.

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